T3DB: Ryanodine receptor 3

Name	Ryanodine receptor 3
Synonyms	Brain ryanodine receptor-calcium release channel Brain-type ryanodine receptor HBRR RYR-3 Type 3 ryanodine receptor
Gene Name	RYR3
Organism	Human
Amino acid sequence	>lcl\|BSEQ0009058\|Ryanodine receptor 3 MAEGGEGGEDEIQFLRTEDEVVLQCIATIHKEQRKFCLAAEGLGNRLCFLEPTSEAKYIP PDLCVCNFVLEQSLSVRALQEMLANTGENGGEGAAQGGGHRTLLYGHAVLLRHSFSGMYL TCLTTSRSQTDKLAFDVGLREHATGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSSER YLHLSVSNGNIQVDASFMQTLWNVHPTCSGSSIEEGYLLGGHVVRLFHGHDECLTIPSTD QNDSQHRRIFYEAGGAGTRARSLWRVEPLRISWSGSNIRWGQAFRLRHLTTGHYLALTED QGLILQDRAKSDTKSTAFSFRASKELKEKLDSSHKRDIEGMGVPEIKYGDSVCFVQHIAS GLWVTYKAQDAKTSRLGPLKRKVILHQEGHMDDGLTLQRCQREESQAARIIRNTTALFSQ FVSGNNRTAAPITLPIEEVLQTLQDLIAYFQPPEEEMRHEDKQNKLRSLKNRQNLFKEEG MLALVLNCIDRLNVYNSVAHFAGIAREESGMAWKEILNLLYKLLAALIRGNRNNCAQFSN NLDWLISKLDRLESSSGILEVLHCILTESPEALNLIAEGHIKSIISLLDKHGRNHKVLDI LCSLCLCNGVAVRANQNLICDNLLPRRNLLLQTRLINDVTSIRPNIFLGVAEGSAQYKKW YFELIIDQVDPFLTAEPTHLRVGWASSSGYAPYPGGGEGWGGNGVGDDLYSYGFDGLHLW SGRIPRAVASINQHLLRSDDVVSCCLDLGVPSISFRINGQPVQGMFENFNTDGLFFPVMS FSAGVKVRFLMGGRHGEFKFLPPSGYAPCYEALLPKEKMRLEPVKEYKRDADGIRDLLGT TQFLSQASFIPCPVDTSQVILPPHLEKIRDRLAENIHELWGMNKIELGWTFGKIRDDNKR QHPCLVEFSKLPETEKNYNLQMSTETLKTLLALGCHIAHVNPAAEEDLKKVKLPKNYMMS NGYKPAPLDLSDVKLLPPQEILVDKLAENAHNVWAKDRIKQGWTYGIQQDLKNKRNPRLV PYALLDERTKKSNRDSLREAVRTFVGYGYNIEPSDQELADSAVEKVSIDKIRFFRVERSY AVRSGKWYFEFEVVTGGDMRVGWARPGCRPDVELGADDQAFVFEGNRGQRWHQGSGYFGR TWQPGDVVGCMINLDDASMIFTLNGELLITNKGSELAFADYEIENGFVPICCLGLSQIGR MNLGTDASTFKFYTMCGLQEGFEPFAVNMNRDVAMWFSKRLPTFVNVPKDHPHIEVMRID GTMDSPPCLKVTHKTFGTQNSNADMIYCRLSMPVECHSSFSHSPCLDSEAFQKRKQMQEI LSHTTTQCYYAIRIFAGQDPSCVWVGWVTPDYHLYSEKFDLNKNCTVTVTLGDERGRVHE SVKRSNCYMVWGGDIVASSQRSNRSNVDLEIGCLVDLAMGMLSFSANGKELGTCYQVEPN TKVFPAVFLQPTSTSLFQFELGKLKNAMPLSAAIFRSEEKNPVPQCPPRLDVQTIQPVLW SRMPNSFLKVETERVSERHGWVVQCLEPLQMMALHIPEENRCVDILELCEQEDLMRFHYH TLRLYSAVCALGNSRVAYALCSHVDLSQLFYAIDNKYLPGLLRSGFYDLLISIHLASAKE RKLMMKNEYIIPITSTTRNIRLFPDESKRHGLPGVGLRTCLKPGFRFSTPCFVVTGEDHQ KQSPEIPLESLRTKALSMLTEAVQCSGAHIRDPVGGSVEFQFVPVLKLIGTLLVMGVFDD DDVRQILLLIDPSVFGEHSAGTEEGAEKEEVTQVEEKAVEAGEKAGKEAPVKGLLQTRLP ESVKLQMCELLSYLCDCELQHRVEAIVAFGDIYVSKLQANQKFRYNELMQALNMSAALTA RKTKEFRSPPQEQINMLLNFQLGENCPCPEEIREELYDFHEDLLLHCGVPLEEEEEEEED TSWTGKLCALVYKIKGPPKPEKEQPTEEEERCPTTLKELISQTMICWAQEDQIQDSELVR MMFNLLRRQYDSIGELLQALRKTYTISHTSVSDTINLLAALGQIRSLLSVRMGKEEELLM INGLGDIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGTEKSQIAFPKMVASCCRFLCYF CRISRQNQKAMFEHLSYLLENSSVGLASPSMRGSTPLDVAASSVMDNNELALSLEEPDLE KVVTYLAGCGLQSCPMLLAKGYPDVGWNPIEGERYLSFLRFAVFVNSESVEENASVVVKL LIRRPECFGPALRGEGGNGLLAAMQGAIKISENPALDLPSQGYKREVSTGDDEEEEEIVH MGNAIMSFYSALIDLLGRCAPEMHLIQTGKGEAIRIRSILRSLVPTEDLVGIISIPLKLP SLNKDGSVSEPDMAANFCPDHKAPMVLFLDRVYGIKDQTFLLHLLEVGFLPDLRASASLD TVSLSTTEAALALNRYICSAVLPLLTRCAPLFAGTEHCTSLIDSTLQTIYRLSKGRSLTK AQRDTIEECLLAICNHLRPSMLQQLLRRLVFDVPQLNEYCKMPLKLLTNHYEQCWKYYCL PSGWGSYGLAVEEELHLTEKLFWGIFDSLSHKKYDPDLFRMALPCLSAIAGALPPDYLDT RITATLEKQISVDADGNFDPKPINTMNFSLPEKLEYIVTKYAEHSHDKWACDKSQSGWKY GISLDENVKTHPLIRPFKTLTEKEKEIYRWPARESLKTMLAVGWTVERTKEGEALVQQRE NEKLRSVSQANQGNSYSPAPLDLSNVVLSRELQGMVEVVAENYHNIWAKKKKLELESKGG GSHPLLVPYDTLTAKEKFKDREKAQDLFKFLQVNGIIVSRGMKDMELDASSMEKRFAYKF LKKILKYVDSAQEFIAHLEAIVSSGKTEKSPRDQEIKFFAKVLLPLVDQYFTSHCLYFLS SPLKPLSSSGYASHKEKEMVAGLFCKLAALVRHRISLFGSDSTTMVSCLHILAQTLDTRT VMKSGSELVKAGLRAFFENAAEDLEKTSENLKLGKFTHSRTQIKGVSQNINYTTVALLPI LTSIFEHVTQHQFGMDLLLGDVQISCYHILCSLYSLGTGKNIYVERQRPALGECLASLAA AIPVAFLEPTLNRYNPLSVFNTKTPRERSILGMPDTVEDMCPDIPQLEGLMKEINDLAES GARYTEMPHVIEVILPMLCNYLSYWWERGPENLPPSTGPCCTKVTSEHLSLILGNILKII NNNLGIDEASWMKRIAVYAQPIISKARPDLLRSHFIPTLEKLKKKAVKTVQEEEQLKADG KGDTQEAELLILDEFAVLCRDLYAFYPMLIRYVDNNRSNWLKSPDADSDQLFRMVAEVFI LWCKSHNFKREEQNFVIQNEINNLAFLTGDSKSKMSKAMQVKSGGQDQERKKTKRRGDLY SIQTSLIVAALKKMLPIGLNMCTPGDQELISLAKSRYSHRDTDEEVREHLRNNLHLQEKS DDPAVKWQLNLYKDVLKSEEPFNPEKTVERVQRISAAVFHLEQVEQPLRSKKAVWHKLLS KQRKRAVVACFRMAPLYNLPRHRSINLFLHGYQRFWIETEEYSFEEKLVQDLAKSPKVEE EEEEETEKQPDPLHQIILYFSRNALTERSKLEDDPLYTSYSSMMAKSCQSGEDEEEDEDK EKTFEEKEMEKQKTLYQQARLHERGAAEMVLQMISASKGEMSPMVVETLKLGIAILNGGN AGVQQKMLDYLKEKKDAGFFQSLSGLMQSCSVLDLNAFERQNKAEGLGMVTEEGTLIVRE RGEKVLQNDEFTRDLFRFLQLLCEGHNSDFQNFLRTQMGNTTTVNVIISTVDYLLRLQES ISDFYWYYSGKDIIDESGQHNFSKALAVTKQIFNSLTEYIQGPCIGNQQSLAHSRLWDAV VGFLHVFANMQMKLSQDSSQIELLKELLDLLQDMVVMLLSLLEGNVVNGTIGKQMVDTLV ESSTNVEMILKFFDMFLKLKDLTSSDTFKEYDPDGKGIISKKEFQKAMEGQKQYTQSEID FLLSCAEADENDMFNYVDFVDRFHEPAKDIGFNVAVLLTNLSEHMPNDSRLKCLLDPAES VLNYFEPYLGRIEIMGGAKKIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEQE KMELFVNFCEDTIFEMQLASQISESDSADRPEEEEEDEDSSYVLEIAGEEEEDGSLEPAS AFAMACASVKRNVTDFLKRATLKNLRKQYRNVKKMTAKELVKVLFSFFWMLFVGLFQLLF TILGGIFQILWSTVFGGGLVEGAKNIRVTKILGDMPDPTQFGIHDDTMEAERAEVMEPGI TTELVHFIKGEKGDTDIMSDLFGLHPKKEGSLKHGPEVGLGDLSEIIGKDEPPTLESTVQ KKRKAQAAEMKAANEAEGKVESEKADMEDGEKEDKDKEEEQAEYLWTEVTKKKKRRCGQK VEKPEAFTANFFKGLEIYQTKLLHYLARNFYNLRFLALFVAFAINFILLFYKVTEEPLEE ETEDVANLWNSFNDEEEEEAMVFFVLQESTGYMAPTLRALAIIHTIISLVCVVGYYCLKV PLVVFKREKEIARKLEFDGLYITEQPSEDDIKGQWDRLVINTPSFPNNYWDKFVKRKVIN KYGDLYGAERIAELLGLDKNALDFSPVEETKAEAASLVSWLSSIDMKYHIWKLGVVFTDN SFLYLAWYTTMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVV VYLYTVVAFNFFRKFYNKSEDDDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGD PYEMYRIVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVREDMETKCFICGIGNDY FDTTPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDC FRKQYEDQLG
Number of residues	4870
Molecular Weight	552037.115
Theoretical pI	Not Available
GO Classification	Functions calcium-induced calcium release activity calcium-release channel activity calcium ion binding ryanodine-sensitive calcium-release channel activity Processes transmembrane transport ion transmembrane transport protein homotetramerization calcium ion transmembrane transport cellular response to ATP cellular response to calcium ion negative regulation of cytosolic calcium ion concentration striated muscle contraction calcium ion transport cellular response to caffeine cellular response to magnesium ion Components junctional membrane complex integral component of membrane cytosol perinuclear region of cytoplasm sarcoplasmic reticulum membrane
General Function	Ryanodine-sensitive calcium-release channel activity
Specific Function	Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm in muscle and thereby plays a role in triggering muscle contraction. May regulate Ca(2+) release by other calcium channels. Calcium channel that mediates Ca(2+)-induced Ca(2+) release from the endoplasmic reticulum in non-muscle cells. Contributes to cellular calcium ion homeostasis (By similarity). Plays a role in cellular calcium signaling.
Pfam Domain Function	Ion_trans (PF00520 ) MIR (PF02815 ) RIH_assoc (PF08454 ) RR_TM4-6 (PF06459 ) RYDR_ITPR (PF01365 ) RyR (PF02026 ) SPRY (PF00622 ) Ins145_P3_rec (PF08709 )
Transmembrane Regions	4187-4207 4410-4430 4485-4505 4610-4630 4633-4653 4672-4692 4753-4773
GenBank Protein ID	Not Available
UniProtKB ID	Q15413
UniProtKB Entry Name	RYR3_HUMAN
Cellular Location	Sarcoplasmic reticulum membrane
Gene sequence	>lcl\|BSEQ0021437\|Ryanodine receptor 3 (RYR3) ATGGCCGAAGGGGGAGAAGGAGGCGAGGACGAGATCCAGTTTCTGAGGACTGAGGATGAA GTGGTACTCCAGTGCATCGCCACCATTCATAAGGAGCAGAGGAAGTTCTGCCTGGCAGCC GAGGGACTTGGGAATCGCCTGTGCTTCTTGGAACCCACTTCAGAAGCCAAGTACATTCCT CCAGATCTCTGCGTCTGCAATTTTGTGCTGGAACAGTCCCTATCTGTCAGAGCCCTGCAG GAAATGCTTGCCAACACAGGTGAAAATGGCGGCGAAGGGGCAGCACAAGGAGGTGGCCAC AGGACCCTGTTATACGGCCATGCAGTTCTCCTGAGGCACTCTTTCAGCGGAATGTATCTA ACATGCTTGACTACATCAAGATCCCAGACAGACAAACTTGCCTTTGATGTAGGTCTACGG GAACATGCCACAGGAGAAGCCTGTTGGTGGACTATACATCCTGCTTCCAAACAGAGGTCC GAAGGAGAGAAAGTTCGAATTGGCGATGACCTCATCCTCGTCAGCGTGTCCTCTGAAAGA TACCTTCATCTCTCAGTATCAAATGGTAACATACAAGTGGATGCCTCCTTTATGCAAACA CTCTGGAATGTACATCCTACGTGCTCAGGAAGTAGCATCGAAGAAGGATACCTACTTGGT GGGCATGTAGTACGTCTTTTCCATGGTCATGATGAATGTTTGACGATACCATCTACAGAC CAGAATGATTCCCAGCACAGGAGGATATTCTACGAAGCTGGGGGAGCTGGGACTCGAGCC AGGTCTCTTTGGAGAGTGGAACCCCTTCGGATAAGCTGGAGTGGCAGTAACATCAGATGG GGCCAGGCTTTCCGACTCCGGCATCTCACCACAGGCCACTACCTGGCCTTGACAGAAGAC CAAGGCCTTATACTGCAAGACCGGGCAAAGTCAGACACCAAGTCCACAGCTTTCTCTTTC CGGGCATCAAAGGAACTCAAGGAGAAATTAGACTCCAGTCACAAGCGAGACATAGAAGGC ATGGGAGTTCCAGAAATCAAGTATGGAGATTCTGTCTGCTTTGTGCAGCATATAGCCAGT GGTCTGTGGGTGACCTACAAAGCACAAGACGCCAAAACTTCCCGCCTGGGACCTCTAAAA AGAAAGGTCATACTCCATCAGGAAGGCCACATGGATGATGGATTAACACTGCAGAGATGC CAGCGTGAGGAGTCCCAGGCTGCTCGGATCATCCGGAACACTACAGCCTTATTCAGCCAG TTTGTCAGCGGAAACAATCGCACAGCTGCCCCCATCACCCTGCCTATAGAAGAAGTCCTG CAGACCCTACAGGACTTGATCGCCTACTTCCAGCCCCCAGAGGAGGAGATGCGACATGAA GACAAGCAGAACAAGCTCCGCTCACTCAAAAACAGACAAAATCTTTTCAAGGAAGAGGGA ATGTTGGCCCTTGTCTTAAATTGCATTGACCGCTTAAATGTCTACAATAGCGTAGCACAC TTTGCAGGGATTGCAAGGGAAGAGAGTGGCATGGCCTGGAAAGAAATTCTGAACCTCCTC TACAAATTGCTGGCTGCTCTCATTCGCGGAAACAGAAACAATTGCGCTCAATTCTCCAAT AACCTTGATTGGCTCATCAGTAAATTGGACAGACTAGAATCTTCCTCAGGTATCTTGGAA GTTTTGCACTGCATCTTAACTGAAAGCCCAGAAGCCTTAAATCTGATAGCGGAGGGCCAC ATCAAGTCGATCATCTCCCTGTTGGATAAGCACGGGCGGAATCACAAGGTTCTGGATATC CTGTGCTCCCTCTGTCTCTGCAATGGGGTTGCAGTGAGAGCCAACCAGAATCTGATCTGT GACAACTTGCTGCCCCGGAGAAACCTACTCCTGCAGACACGACTGATTAACGATGTAACC AGTATCCGGCCAAACATCTTCCTGGGAGTCGCGGAGGGCTCAGCCCAGTACAAGAAGTGG TACTTCGAGCTGATTATCGACCAGGTGGACCCCTTCCTAACAGCAGAGCCCACACATCTG CGGGTGGGCTGGGCCTCTTCTTCAGGCTATGCCCCATACCCAGGAGGTGGAGAAGGATGG GGAGGCAATGGTGTTGGTGACGACCTGTACTCCTATGGCTTTGATGGACTTCACCTTTGG TCAGGCCGGATACCCAGAGCTGTGGCTTCCATCAACCAGCACCTCCTGAGATCGGATGAC GTGGTAAGCTGCTGCCTGGACCTCGGGGTGCCCAGCATCTCATTCCGCATCAATGGGCAG CCCGTGCAGGGGATGTTTGAGAACTTCAACACAGACGGGCTCTTCTTCCCTGTGATGAGC TTTTCAGCAGGTGTCAAAGTACGTTTCCTGATGGGTGGACGTCATGGAGAGTTTAAGTTC CTGCCTCCCTCTGGCTATGCCCCTTGCTATGAAGCCTTACTTCCAAAAGAGAAGATGAGA TTGGAGCCTGTCAAAGAATATAAACGTGATGCTGATGGCATTAGAGATCTCTTGGGTACC ACCCAGTTCCTCTCCCAAGCCTCTTTCATCCCATGCCCCGTAGACACCAGTCAGGTTATT TTGCCACCTCACCTAGAAAAGATCCGAGACAGACTAGCTGAAAACATCCATGAGCTTTGG GGAATGAATAAAATAGAACTTGGCTGGACTTTCGGCAAGATACGAGATGACAATAAAAGA CAACACCCTTGCCTTGTGGAGTTTTCAAAGCTCCCAGAAACTGAGAAGAACTATAACCTG CAAATGTCAACTGAAACCTTAAAAACCCTCTTGGCCCTGGGGTGCCACATTGCTCATGTT AACCCAGCTGCTGAGGAGGATCTCAAGAAGGTCAAACTGCCCAAAAACTATATGATGTCC AACGGCTATAAGCCAGCCCCTTTGGATTTGTCTGATGTGAAGCTGTTACCTCCTCAAGAA ATTTTAGTGGATAAGCTTGCAGAAAATGCACACAATGTTTGGGCAAAAGACAGAATAAAA CAAGGATGGACCTATGGCATCCAACAGGATTTGAAGAACAAAAGAAATCCCCGTCTGGTG CCATATGCATTACTGGATGAGCGTACCAAGAAGTCAAACAGGGACAGCCTGCGGGAAGCT GTGCGCACTTTTGTTGGTTACGGGTATAACATTGAGCCATCAGACCAAGAACTAGCTGAC TCGGCTGTGGAGAAGGTCAGCATAGACAAGATCCGATTTTTCCGGGTAGAGCGATCTTAT GCAGTGAGATCTGGAAAGTGGTATTTTGAGTTTGAAGTGGTGACTGGAGGAGACATGCGA GTCGGCTGGGCGAGGCCAGGCTGTCGACCTGATGTCGAGCTGGGGGCCGATGACCAAGCC TTTGTGTTTGAAGGCAACAGGGGCCAGCGTTGGCATCAAGGAAGTGGGTATTTTGGGCGT ACCTGGCAGCCAGGGGATGTGGTCGGATGTATGATTAACCTGGATGATGCTTCAATGATC TTCACACTGAATGGGGAGCTGCTGATCACCAACAAAGGCTCTGAACTTGCCTTCGCTGAC TACGAGATTGAGAATGGCTTCGTGCCCATCTGCTGTCTGGGTCTATCTCAGATCGGCCGC ATGAATCTCGGGACAGATGCCAGTACCTTCAAGTTTTATACCATGTGCGGTCTCCAAGAG GGCTTTGAGCCTTTTGCTGTCAACATGAACAGAGATGTTGCTATGTGGTTCAGCAAGCGC CTCCCGACGTTTGTCAACGTGCCAAAGGATCATCCACACATAGAGGTCATGAGGATTGAT GGCACCATGGACAGCCCTCCGTGTCTCAAGGTGACGCATAAGACATTTGGCACACAGAAT AGCAATGCCGACATGATCTATTGCCGCTTGAGCATGCCTGTCGAGTGCCACTCCTCCTTC AGCCACAGCCCCTGTCTGGACAGTGAAGCTTTCCAGAAAAGGAAACAGATGCAAGAAATA CTCTCTCATACAACAACACAGTGCTACTACGCCATCCGCATCTTTGCTGGACAGGATCCA TCCTGTGTCTGGGTCGGATGGGTGACTCCAGACTATCACTTGTACAGTGAAAAGTTTGAC CTGAATAAAAACTGCACAGTGACTGTCACCCTAGGGGATGAAAGAGGCCGGGTCCATGAA AGTGTGAAACGCAGCAACTGCTACATGGTCTGGGGTGGAGACATTGTAGCCAGTTCCCAG AGATCAAATCGGAGCAACGTGGACCTGGAGATCGGCTGTCTCGTGGATCTGGCCATGGGC ATGTTGTCCTTCTCAGCCAATGGAAAGGAACTGGGCACCTGCTACCAGGTGGAGCCTAAT ACCAAAGTGTTTCCAGCAGTCTTCCTGCAGCCTACAAGTACTTCTTTGTTTCAGTTTGAA CTTGGAAAGCTGAAGAACGCAATGCCCCTGTCAGCGGCCATATTCAGGAGTGAAGAGAAG AACCCAGTCCCACAGTGTCCACCTCGGCTGGACGTCCAAACCATCCAGCCCGTGCTCTGG AGCCGCATGCCCAACAGCTTCCTGAAGGTGGAGACCGAGCGTGTGAGCGAGCGCCACGGC TGGGTGGTGCAGTGCCTGGAGCCCCTGCAGATGATGGCGCTCCACATCCCCGAGGAGAAC AGGTGTGTGGATATCCTGGAGCTCTGTGAGCAGGAGGACCTGATGCGGTTCCATTACCAC ACGCTGAGGCTCTACAGCGCGGTGTGCGCCCTGGGAAACAGCCGCGTGGCCTACGCCCTG TGCAGCCACGTGGACCTCTCCCAGCTCTTCTATGCCATTGACAACAAGTACCTCCCCGGC CTCCTTCGATCTGGTTTCTATGACCTGCTCATCAGCATCCACCTGGCCAGCGCCAAGGAG AGGAAGCTGATGATGAAGAACGAGTACATCATCCCCATTACCAGCACCACCAGGAATATC CGCCTCTTCCCGGACGAGTCCAAGAGGCATGGACTGCCTGGGGTGGGCCTGAGAACATGT CTCAAGCCCGGGTTCAGGTTCTCCACCCCTTGCTTTGTTGTGACTGGTGAGGATCACCAA AAGCAGAGCCCCGAGATTCCCTTGGAGAGTCTCAGGACGAAGGCTCTGAGTATGCTGACA GAGGCAGTGCAGTGCAGCGGGGCCCACATCCGAGACCCTGTAGGGGGGTCTGTGGAGTTC CAGTTTGTGCCTGTGCTGAAACTCATTGGAACCCTGCTGGTCATGGGCGTGTTTGATGAT GATGATGTTCGGCAGATCCTCCTCCTGATTGATCCCTCTGTGTTTGGGGAGCATAGTGCG GGGACAGAGGAGGGAGCAGAAAAGGAGGAAGTGACCCAGGTGGAGGAGAAGGCTGTGGAG GCTGGGGAGAAGGCCGGCAAGGAGGCTCCTGTCAAAGGCTTGTTGCAGACTCGATTACCC GAATCCGTCAAGCTGCAGATGTGTGAGCTCCTCAGCTATCTCTGCGACTGTGAGCTGCAG CACCGAGTGGAGGCCATTGTGGCATTTGGTGACATTTATGTCTCCAAGCTGCAGGCAAAT CAGAAGTTCCGCTACAATGAGCTCATGCAGGCCCTGAACATGTCTGCGGCCCTGACTGCC CGGAAGACCAAGGAGTTCCGCTCACCCCCACAGGAGCAGATCAACATGCTGCTTAACTTT CAACTGGGAGAGAACTGCCCCTGCCCAGAGGAGATTCGGGAGGAGCTGTATGATTTCCAT GAGGACCTTCTCCTTCACTGTGGGGTTCCTTTGGAAGAAGAGGAAGAGGAGGAGGAGGAC ACCTCCTGGACAGGAAAACTCTGTGCCTTGGTTTACAAAATCAAAGGCCCACCCAAGCCA GAGAAGGAGCAGCCGACGGAGGAGGAGGAGAGATGCCCCACAACATTGAAGGAACTCATC TCACAGACGATGATCTGCTGGGCCCAGGAGGACCAGATCCAGGATTCAGAGCTGGTCCGA ATGATGTTCAACCTCCTCCGGAGGCAGTATGACAGCATTGGGGAGCTGCTGCAGGCGCTG CGGAAGACCTACACCATCAGCCACACCTCTGTAAGCGACACCATCAACCTGCTGGCTGCC CTGGGCCAAATCCGCTCCCTCCTCAGTGTCAGGATGGGCAAGGAAGAGGAGTTGCTCATG ATCAATGGGCTGGGAGACATAATGAACAACAAGGTGTTTTACCAGCATCCCAACCTCATG AGAGTCCTGGGCATGCACGAGACGGTGATGGAGGTGATGGTGAACGTGTTGGGTACAGAG AAATCTCAGATTGCATTTCCAAAGATGGTTGCTAGCTGCTGCCGTTTCCTTTGCTATTTC TGTCGAATTAGCCGGCAAAATCAGAAGGCCATGTTTGAGCATCTGAGTTATCTTCTGGAG AATAGCAGTGTTGGCCTAGCCTCCCCGTCGATGAGGGGATCCACCCCGCTGGATGTGGCA GCTTCCTCTGTGATGGACAACAATGAGTTAGCGCTGAGCTTAGAGGAACCAGACCTCGAG AAGGTGGTGACCTACTTGGCAGGCTGTGGCCTACAGAGCTGCCCCATGCTTCTGGCCAAA GGATACCCTGATGTCGGCTGGAACCCCATTGAAGGGGAACGCTACCTGTCCTTCCTGAGG TTTGCTGTCTTCGTGAACAGTGAGAGTGTGGAAGAAAACGCCAGCGTTGTGGTCAAGCTG CTCATCAGACGCCCAGAGTGCTTCGGCCCGGCCCTGCGGGGTGAGGGGGGAAACGGGCTC TTGGCAGCCATGCAGGGTGCCATTAAGATCTCTGAGAACCCAGCGCTCGACCTCCCCTCT CAAGGATACAAAAGAGAAGTCAGCACGGGGGACGATGAAGAGGAAGAAGAAATCGTGCAT ATGGGCAATGCAATTATGTCATTTTATTCGGCCCTTATAGATCTACTGGGCCGCTGTGCT CCTGAAATGCACCTCATCCAGACAGGAAAGGGGGAAGCCATCCGCATCAGGTCCATCCTG CGCTCCCTGGTCCCCACAGAAGACCTGGTTGGGATCATCAGCATCCCCTTGAAACTGCCC TCCCTCAACAAAGATGGGTCGGTCAGTGAGCCAGATATGGCGGCCAATTTCTGCCCTGAC CACAAGGCACCTATGGTGCTGTTCTTGGACCGCGTTTATGGCATTAAGGATCAAACTTTT CTGCTCCACTTGCTGGAGGTTGGATTTTTACCTGACCTAAGAGCTTCTGCCTCTCTAGAT ACAGTTTCCCTAAGCACCACAGAGGCTGCGCTTGCACTAAATAGGTATATATGTTCTGCT GTGCTCCCGCTCCTCACAAGATGTGCCCCTCTCTTTGCCGGAACAGAACACTGCACCTCT CTGATTGATTCCACACTGCAGACAATATACAGGCTATCCAAGGGACGTTCCCTCACCAAA GCACAAAGGGACACTATAGAAGAATGTTTGCTTGCCATTTGCAATCACTTGAGGCCTTCC ATGTTACAGCAACTCCTGCGACGCCTCGTTTTTGATGTGCCGCAACTCAATGAATACTGC AAAATGCCTCTCAAGCTTCTGACGAATCACTATGAACAGTGTTGGAAGTATTACTGCCTG CCTTCAGGATGGGGGAGCTACGGGCTAGCTGTGGAAGAAGAGCTGCACCTAACGGAGAAG CTTTTCTGGGGGATTTTTGACTCGCTCTCCCATAAGAAATATGACCCAGATCTTTTCCGA ATGGCCCTGCCTTGTCTCAGTGCTATAGCTGGGGCCTTGCCACCAGATTATTTAGATACC AGAATCACAGCCACGTTGGAGAAACAGATCTCAGTGGATGCGGATGGCAACTTTGACCCA AAACCTATTAACACCATGAATTTTTCCTTGCCTGAAAAATTGGAATACATCGTCACCAAG TATGCTGAGCATTCACATGATAAATGGGCCTGTGACAAGAGTCAGAGTGGATGGAAATAT GGGATTTCCCTGGATGAAAATGTGAAGACCCACCCACTGATAAGGCCTTTCAAGACATTA ACGGAGAAGGAGAAGGAAATTTATCGCTGGCCTGCGCGAGAGTCCCTGAAAACCATGCTG GCTGTGGGCTGGACTGTGGAGAGGACCAAAGAGGGAGAAGCTTTGGTTCAACAGCGGGAA AATGAGAAGCTTCGAAGTGTGTCCCAGGCCAACCAGGGCAACAGCTACAGTCCTGCTCCC CTCGACCTCTCAAACGTTGTGCTCTCCAGAGAGCTCCAGGGAATGGTGGAGGTCGTGGCT GAGAACTATCACAATATCTGGGCCAAGAAGAAGAAGCTGGAGCTGGAGAGCAAAGGTGGT GGCAGCCACCCTCTTCTGGTACCATATGACACCTTGACTGCCAAGGAAAAGTTCAAGGAC CGGGAGAAGGCACAGGACCTGTTTAAGTTCCTCCAAGTGAATGGCATCATAGTTTCCAGG GGTATGAAGGATATGGAGCTGGATGCCTCCTCCATGGAGAAGAGGTTTGCCTATAAGTTC TTGAAGAAGATCCTGAAATACGTTGATTCTGCTCAAGAATTTATTGCCCATTTAGAAGCC ATTGTCAGCAGTGGGAAAACTGAAAAGTCTCCCCGTGACCAGGAGATCAAATTCTTTGCC AAAGTTCTCCTCCCGCTGGTTGACCAGTACTTCACCAGTCATTGCCTCTACTTCTTGTCA TCCCCTCTGAAGCCCCTTAGCAGCAGCGGATATGCCTCCCATAAGGAGAAAGAAATGGTG GCCGGCCTGTTCTGCAAACTTGCCGCTCTCGTTAGACACAGAATTTCCCTCTTTGGTAGT GATTCTACTACAATGGTGAGCTGTCTTCACATCTTAGCTCAGACACTTGACACAAGGACT GTCATGAAGTCAGGCTCAGAGCTGGTGAAGGCTGGGTTACGAGCATTCTTTGAAAATGCT GCAGAAGATTTGGAGAAGACTTCAGAAAACCTGAAACTTGGGAAGTTCACCCATTCCCGA ACGCAGATTAAAGGCGTTTCTCAGAATATTAACTACACTACAGTGGCTCTGCTCCCCATC CTGACGTCCATCTTTGAGCACGTCACTCAGCATCAGTTTGGAATGGATCTACTCTTGGGT GATGTGCAGATTTCATGCTACCACATACTGTGCAGCCTCTACTCCCTTGGGACGGGAAAG AACATTTATGTTGAAAGGCAACGCCCTGCCCTTGGAGAATGTCTGGCCTCGCTGGCAGCT GCCATACCAGTGGCATTCCTGGAGCCCACCCTTAATCGCTACAATCCACTCTCGGTCTTC AACACCAAAACCCCCAGGGAGAGGTCTATTCTGGGGATGCCAGACACGGTAGAAGACATG TGTCCTGACATCCCCCAGCTGGAAGGCCTGATGAAGGAAATCAACGACCTGGCCGAGTCA GGGGCCCGGTACACAGAGATGCCCCATGTCATCGAGGTGATCTTACCCATGCTCTGCAAC TACTTGTCCTACTGGTGGGAGCGGGGTCCTGAGAACCTGCCCCCCAGCACAGGGCCATGC TGCACCAAGGTCACCTCTGAACACCTCAGTCTCATCCTGGGCAACATTCTGAAAATCATC AACAACAACCTGGGCATCGATGAGGCCTCCTGGATGAAGCGCATTGCAGTGTATGCACAG CCCATCATCAGCAAAGCCAGGCCCGACCTGCTGAGAAGCCACTTCATCCCAACTCTGGAG AAGCTGAAGAAAAAGGCTGTCAAGACGGTGCAGGAGGAGGAGCAGTTGAAAGCCGATGGC AAAGGGGACACCCAGGAGGCAGAACTCCTCATCCTGGACGAGTTCGCGGTCCTCTGCAGA GATCTCTATGCCTTCTACCCCATGCTGATCCGCTACGTGGACAACAACAGATCTAACTGG CTGAAAAGTCCTGATGCTGATTCTGACCAGCTCTTCCGCATGGTGGCAGAAGTCTTCATT CTGTGGTGTAAATCTCATAACTTCAAGAGAGAAGAGCAAAATTTTGTGATTCAGAATGAA ATTAATAATTTGGCATTTTTAACTGGAGACAGCAAAAGCAAGATGTCAAAAGCCATGCAA GTAAAGTCTGGAGGACAAGACCAGGAGCGGAAGAAGACAAAGCGGCGGGGAGACTTGTAT TCCATCCAGACCTCCCTCATCGTGGCTGCACTCAAGAAAATGCTGCCCATTGGTTTGAAT ATGTGTACTCCAGGCGACCAGGAGCTGATCTCCCTCGCAAAATCGCGATACAGCCATAGG GACACAGATGAAGAGGTCAGAGAACATCTGCGGAACAACTTGCACTTGCAGGAAAAGTCT GATGACCCAGCTGTAAAATGGCAACTGAACCTCTACAAGGATGTTCTGAAGAGTGAAGAA CCTTTCAATCCGGAAAAGACAGTGGAGCGTGTGCAGAGAATTTCAGCAGCTGTCTTCCAC CTGGAACAGGTGGAACAGCCTTTGAGGTCCAAGAAGGCCGTCTGGCACAAACTGTTATCA AAGCAACGGAAACGGGCAGTGGTGGCCTGTTTCAGGATGGCCCCTCTCTACAACCTGCCC AGGCACCGCTCTATTAACCTCTTCCTCCATGGCTATCAGAGATTTTGGATAGAAACAGAG GAGTATTCCTTTGAAGAGAAACTAGTACAGGATTTGGCTAAATCTCCAAAGGTGGAAGAG GAGGAGGAGGAAGAGACAGAAAAACAACCTGACCCACTACATCAGATCATTCTCTATTTT AGCCGCAACGCTCTCACGGAGAGGAGCAAATTGGAAGACGACCCTTTGTACACCTCCTAT TCCAGCATGATGGCCAAGAGTTGTCAAAGTGGTGAGGATGAAGAAGAAGATGAAGACAAG GAAAAAACATTCGAAGAGAAAGAGATGGAGAAGCAAAAAACCCTCTATCAGCAAGCTCGG CTGCATGAGCGTGGTGCTGCAGAGATGGTCCTTCAGATGATAAGCGCTAGCAAAGGTGAG ATGAGCCCCATGGTGGTTGAGACGCTGAAGCTGGGGATCGCCATTCTGAACGGAGGCAAT GCTGGTGTGCAACAGAAAATGCTAGATTACCTAAAGGAGAAAAAGGATGCTGGATTCTTT CAAAGCCTTTCTGGTCTTATGCAGTCTTGCAGTGTCCTTGATTTGAATGCATTTGAGAGG CAGAATAAAGCTGAAGGCCTGGGGATGGTGACTGAAGAAGGAACACTCATTGTTCGGGAA CGTGGTGAAAAAGTACTCCAGAATGACGAGTTCACGCGTGATCTCTTTAGATTCCTACAG TTACTTTGTGAGGGACATAACAGTGACTTTCAGAACTTCCTGCGGACTCAGATGGGCAAC ACCACCACCGTGAATGTCATCATCAGCACTGTGGACTACCTTCTGCGTCTGCAGGAATCA ATCAGTGATTTCTACTGGTATTATTCAGGGAAGGACATCATTGATGAATCTGGACAGCAC AATTTTTCCAAAGCTCTGGCAGTCACCAAGCAGATTTTCAATTCTCTTACAGAATACATC CAGGGCCCTTGCATTGGTAATCAACAGAGCCTGGCTCACAGCAGGCTGTGGGACGCAGTG GTTGGCTTCCTCCATGTCTTTGCTAATATGCAGATGAAACTCTCTCAGGATTCCAGTCAG ATCGAGCTGCTGAAGGAACTCTTGGATCTCCTTCAGGACATGGTGGTGATGCTTCTGTCC CTCCTGGAAGGGAATGTGGTAAATGGCACCATTGGCAAGCAGATGGTTGACACACTGGTA GAATCATCTACCAATGTAGAAATGATCTTGAAATTCTTTGACATGTTCTTGAAACTTAAA GACTTAACCAGCTCAGACACCTTCAAAGAATATGACCCAGATGGTAAAGGAATTATCTCC AAAAAAGAATTCCAGAAGGCCATGGAAGGGCAAAAACAGTACACGCAGTCAGAGATTGAC TTTCTCCTGTCGTGTGCAGAAGCTGATGAGAATGACATGTTTAATTACGTTGATTTTGTA GACCGGTTCCATGAGCCAGCCAAGGACATAGGGTTTAATGTGGCTGTGTTATTGACAAAT CTTTCTGAACACATGCCAAACGATTCCCGCCTGAAGTGTCTGTTGGACCCAGCAGAAAGT GTGCTAAATTACTTCGAACCCTACCTAGGACGCATCGAGATCATGGGTGGGGCCAAGAAG ATTGAGCGTGTTTATTTTGAGATCAGTGAATCCAGTCGCACTCAGTGGGAGAAGCCCCAG GTGAAGGAATCTAAGCGACAGTTCATTTTTGATGTTGTCAATGAAGGTGGGGAGCAGGAA AAGATGGAGCTGTTTGTGAACTTCTGTGAGGACACCATCTTTGAAATGCAGTTAGCATCT CAGATCTCTGAATCCGATTCAGCTGACAGGCCAGAAGAGGAGGAAGAAGATGAAGATTCT TCTTACGTGTTAGAAATTGCGGGTGAAGAGGAAGAAGACGGGTCTCTTGAGCCGGCCTCT GCATTTGCTATGGCCTGTGCCTCTGTGAAGAGGAATGTCACCGACTTCCTGAAGAGAGCA ACCCTGAAGAACCTCAGGAAGCAGTACAGGAACGTGAAAAAGATGACTGCGAAGGAGCTG GTGAAGGTGCTCTTCTCCTTTTTCTGGATGCTGTTCGTGGGGCTATTCCAGTTGCTCTTC ACCATCCTGGGAGGAATCTTTCAGATCCTCTGGAGCACAGTGTTTGGAGGGGGCCTGGTA GAAGGGGCAAAGAACATCAGAGTGACCAAGATCCTGGGTGACATGCCTGACCCAACCCAA TTTGGTATCCATGATGACACTATGGAGGCTGAGAGGGCAGAGGTGATGGAGCCAGGTATC ACCACTGAACTAGTACACTTCATAAAGGGGGAGAAGGGAGATACAGATATCATGTCAGAC CTCTTTGGACTCCACCCAAAGAAAGAGGGCAGCTTAAAGCATGGGCCTGAAGTGGGTTTG GGTGACCTCTCAGAAATTATTGGCAAGGATGAACCCCCTACATTAGAGAGTACTGTACAG AAGAAGAGGAAAGCTCAGGCAGCAGAAATGAAAGCAGCAAATGAAGCAGAAGGAAAAGTA GAATCCGAGAAGGCAGACATGGAAGATGGAGAGAAGGAAGACAAAGACAAAGAAGAGGAG CAAGCTGAGTACCTGTGGACAGAAGTGACAAAAAAGAAGAAGCGGCGGTGTGGTCAGAAG GTTGAGAAGCCGGAAGCTTTCACAGCCAATTTCTTTAAAGGGCTGGAAATCTATCAGACC AAGTTACTGCATTACCTGGCCAGGAATTTCTACAACCTGAGGTTCCTTGCTCTGTTTGTA GCCTTCGCTATCAACTTCATCCTGCTTTTTTATAAGGTCACTGAAGAACCTTTAGAAGAA GAGACAGAGGATGTTGCAAACCTATGGAATTCCTTTAATGACGAGGAAGAGGAAGAAGCG ATGGTATTCTTTGTCCTTCAGGAGAGCACCGGGTATATGGCACCAACCCTGCGTGCCCTG GCCATCATCCATACCATCATCTCTCTAGTCTGTGTGGTGGGCTACTACTGCCTGAAGGTG CCTTTGGTGGTTTTCAAAAGGGAAAAAGAAATCGCCAGGAAGCTGGAGTTTGATGGCCTA TATATCACCGAACAGCCATCTGAAGATGACATCAAGGGGCAGTGGGACCGCTTGGTGATC AACACACCATCTTTTCCTAATAACTACTGGGACAAGTTTGTAAAGAGAAAGGTGATCAAC AAGTATGGAGATCTCTACGGAGCAGAACGCATTGCTGAACTTCTGGGTTTGGACAAAAAT GCTCTTGACTTTAGCCCAGTAGAAGAGACCAAAGCAGAAGCGGCTTCTCTGGTGTCATGG CTAAGTTCCATAGACATGAAGTACCATATCTGGAAGCTTGGAGTTGTTTTTACTGACAAC TCCTTTCTCTACCTTGCCTGGTATACAACCATGTCAGTCCTGGGCCACTACAATAACTTC TTCTTTGCTGCTCACCTATTGGACATCGCAATGGGCTTCAAGACACTGAGGACCATTCTG TCATCTGTAACTCACAATGGCAAACAGTTGGTTCTGACTGTCGGTCTCCTGGCCGTGGTG GTTTATCTCTATACTGTGGTGGCTTTCAACTTCTTCCGCAAGTTCTACAACAAAAGCGAA GACGATGACGAGCCCGATATGAAGTGCGACGACATGATGACGTGTTACCTTTTCCACATG TACGTGGGAGTGAGAGCAGGAGGTGGCATTGGTGATGAAATTGAAGACCCTGCTGGTGAT CCTTATGAAATGTATCGCATTGTCTTTGACATTACCTTTTTCTTCTTCGTCATTGTCATC TTGCTGGCCATCATTCAAGGTCTTATTATTGATGCTTTCGGAGAGCTAAGAGACCAGCAG GAACAAGTACGAGAAGATATGGAGACTAAATGTTTCATCTGTGGGATTGGCAATGACTAC TTTGACACAACCCCTCATGGTTTTGAAACACATACATTACAAGAGCACAACTTAGCCAAC TACTTGTTCTTTCTGATGTATTTGATTAATAAAGATGAAACAGAGCACACGGGTCAGGAA TCTTATGTCTGGAAGATGTACCAAGAAAGGTGTTGGGATTTCTTCCCAGCCGGTGACTGC TTTCGTAAACAATATGAAGATCAGCTTGGATAA
GenBank Gene ID	Not Available
GeneCard ID	Not Available
GenAtlas ID	Not Available
HGNC ID	HGNC:10485
Chromosome Location	15
Locus	Not Available
References	Nakashima Y, Nishimura S, Maeda A, Barsoumian EL, Hakamata Y, Nakai J, Allen PD, Imoto K, Kita T: Molecular cloning and characterization of a human brain ryanodine receptor. FEBS Lett. 1997 Nov 3;417(1):157-62. 9395096 Leeb T, Brenig B: cDNA cloning and sequencing of the human ryanodine receptor type 3 (RYR3) reveals a novel alternative splice site in the RYR3 gene. FEBS Lett. 1998 Feb 27;423(3):367-70. 9515741 Zody MC, Garber M, Sharpe T, Young SK, Rowen L, O'Neill K, Whittaker CA, Kamal M, Chang JL, Cuomo CA, Dewar K, FitzGerald MG, Kodira CD, Madan A, Qin S, Yang X, Abbasi N, Abouelleil A, Arachchi HM, Baradarani L, Birditt B, Bloom S, Bloom T, Borowsky ML, Burke J, Butler J, Cook A, DeArellano K, DeCaprio D, Dorris L 3rd, Dors M, Eichler EE, Engels R, Fahey J, Fleetwood P, Friedman C, Gearin G, Hall JL, Hensley G, Johnson E, Jones C, Kamat A, Kaur A, Locke DP, Madan A, Munson G, Jaffe DB, Lui A, Macdonald P, Mauceli E, Naylor JW, Nesbitt R, Nicol R, O'Leary SB, Ratcliffe A, Rounsley S, She X, Sneddon KM, Stewart S, Sougnez C, Stone SM, Topham K, Vincent D, Wang S, Zimmer AR, Birren BW, Hood L, Lander ES, Nusbaum C: Analysis of the DNA sequence and duplication history of human chromosome 15. Nature. 2006 Mar 30;440(7084):671-5. 16572171 Martin C, Chapman KE, Seckl JR, Ashley RH: Partial cloning and differential expression of ryanodine receptor/calcium-release channel genes in human tissues including the hippocampus and cerebellum. Neuroscience. 1998 Jul;85(1):205-16. 9607712 Hakamata Y, Nishimura S, Nakai J, Nakashima Y, Kita T, Imoto K: Involvement of the brain type of ryanodine receptor in T-cell proliferation. FEBS Lett. 1994 Sep 26;352(2):206-10. 7523185 Sorrentino V, Giannini G, Malzac P, Mattei MG: Localization of a novel ryanodine receptor gene (RYR3) to human chromosome 15q14-q15 by in situ hybridization. Genomics. 1993 Oct;18(1):163-5. 8276408 Lynn S, Morgan JM, Lamb HK, Meissner G, Gillespie JI: Isolation and partial cloning of ryanodine-sensitive Ca2+ release channel protein isoforms from human myometrial smooth muscle. FEBS Lett. 1995 Sep 18;372(1):6-12. 7556644 Schwarzmann N, Kunerth S, Weber K, Mayr GW, Guse AH: Knock-down of the type 3 ryanodine receptor impairs sustained Ca2+ signaling via the T cell receptor/CD3 complex. J Biol Chem. 2002 Dec 27;277(52):50636-42. Epub 2002 Sep 26. 12354756 Wen H, Kang S, Song Y, Song Y, Yang HJ, Kim MH, Park S: Characterization of the binding sites for the interactions between FKBP12 and intracellular calcium release channels. Arch Biochem Biophys. 2012 Jan 1;517(1):37-42. doi: 10.1016/j.abb.2011.11.004. Epub 2011 Nov 11. 22100703