Kinesin-like protein KIF14
| Name | Kinesin-like protein KIF14 |
|---|---|
| Synonyms |
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| Gene Name | KIF14 |
| Organism | Human |
| Amino acid sequence | >lcl|BSEQ0009147|Kinesin-like protein KIF14 MSLHSTHNRNNSGDILDIPSSQNSSSLNALTHSSRLKLHLKSDMSECENDDPLLRSAGKV RDINRTYVISASRKTADMPLTPNPVGRLALQRRTTRNKESSLLVSELEDTTEKTAETRLT LQRRAKTDSAEKWKTAEIDSVKMTLNVGGETENNGVSKESRTNVRIVNNAKNSFVASSVP LDEDPQVIEMMADKKYKETFSAPSRANENVALKYSSNRPPIASLSQTEVVRSGHLTTKPT QSKLDIKVLGTGNLYHRSIGKEIAKTSNKFGSLEKRTPTKCTTEHKLTTKCSLPQLKSPA PSILKNRMSNLQVKQRPKSSFLANKQERSAENTILPEEETVVQNTSAGKDPLKVENSQVT VAVRVRPFTKREKIEKASQVVFMSGKEITVEHPDTKQVYNFIYDVSFWSFDECHPHYASQ TTVYEKLAAPLLERAFEGFNTCLFAYGQTGSGKSYTMMGFSEEPGIIPRFCEDLFSQVAR KQTQEVSYHIEMSFFEVYNEKIHDLLVCKDENGQRKQPLRVREHPVYGPYVEALSMNIVS SYADIQSWLELGNKQRATAATGMNDKSSRSHSVFTLVMTQTKTEFVEGEEHDHRITSRIN LIDLAGSERCSTAHTNGDRLKEGVSINKSLLTLGKVISALSEQANQRSVFIPYRESVLTW LLKESLGGNSKTAMIATISPAASNIEETLSTLRYANQARLIVNIAKVNEDMNAKLIRELK AEIAKLKAAQRNSRNIDPERYRLCRQEITSLRMKLHQQERDMAEMQRVWKEKFEQAEKRK LQETKELQKAGIMFQMDNHLPNLVNLNEDPQLSEMLLYMIKEGTTTVGKYKPNSSHDIQL SGVLIADDHCTIKNFGGTVSIIPVGEAKTYVNGKHILEITVLRHGDRVILGGDHYFRFNH PVEVQKGKRPSGRDTPISEGPKDFEFAKNELLMAQRSQLEAEIKEAQLKAKEEMMQGIQI AKEMAQQELSSQKAAYESKIKALEAELREESQRKKMQEINNQKANHKIEELEKAKQHLEQ EIYVNKKRLEMETLATKQALEDHSIRHARILEALETEKQKIAKEVQILQQNRNNRDKTFT VQTTWSSMKLSMMIQEANAISSKLKTYYVFGRHDISDKSSSDTSIRVRNLKLGISTFWSL EKFESKLAAMKELYESNGSNRGEDAFCDPEDEWEPDITDAPVSSLSRRRSRSLMKNRRIS GCLHDIQVHPIKNLHSSHSSGLMDKSSTIYSNSAESFLPGICKELIGSSLDFFGQSYDEE RTIADSLINSFLKIYNGLFAISKAHEEQDEESQDNLFSSDRAIQSLTIQTACAFEQLVVL MKHWLSDLLPCTNIARLEDELRQEVKKLGGYLQLFLQGCCLDISSMIKEAQKNAIQIVQQ AVKYVGQLAVLKGSKLHFLENGNNKAASVQEEFMDAVCDGVGLGMKILLDSGLEKAKELQ HELFRQCTKNEVTKEMKTNAMGLIRSLENIFAESKIKSFRRQVQEENFEYQDFKRMVNRA PEFLKLKHCLEKAIEIIISALKGCHSDINLLQTCVESIRNLASDFYSDFSVPSTSVGSYE SRVTHIVHQELESLAKSLLFCFESEESPDLLKPWETYNQNTKEEHQQSKSSGIDGSKNKG VPKRVYELHGSSPAVSSEECTPSRIQWV |
| Number of residues | 1648 |
| Molecular Weight | 186490.045 |
| Theoretical pI | Not Available |
| GO Classification | Functions
Processes
Components
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| General Function | Tubulin binding |
| Specific Function | Microtubule motor protein that binds to microtubules with high affinity through each tubulin heterodimer and has an ATPase activity (By similarity). Plays a role in many processes like cell division, cytokinesis and also in cell proliferation and apoptosis (PubMed:24784001, PubMed:16648480). During cytokinesis, targets to central spindle and midbody through its interaction with PRC1 and CIT respectively (PubMed:16431929). Regulates cell growth through regulation of cell cycle progression and cytokinesis (PubMed:24854087). During cell cycle progression acts through SCF-dependent proteasomal ubiquitin-dependent protein catabolic process which controls CDKN1B degradation, resulting in positive regulation of cyclins, including CCNE1, CCND1 and CCNB1 (PubMed:24854087). During late neurogenesis, regulates the cerebellar, cerebral cortex and olfactory bulb development through regulation of apoptosis, cell proliferation and cell division (By similarity). Also is required for chromosome congression and alignment during mitotic cell cycle process (PubMed:15843429). Regulates cell spreading, focal adhesion dynamics, and cell migration through its interaction with RADIL resulting in regulation of RAP1A-mediated inside-out integrin activation by tethering RADIL on microtubules (PubMed:23209302). |
| Pfam Domain Function | |
| Transmembrane Regions | Not Available |
| GenBank Protein ID | Not Available |
| UniProtKB ID | Q15058 |
| UniProtKB Entry Name | KIF14_HUMAN |
| Cellular Location | Nucleus |
| Gene sequence | >lcl|BSEQ0017703|Kinesin-like protein KIF14 (KIF14) ATGAGCTTCTTTGAAGTATATAATGAAAAAATTCACGACCTTCTGGTTTGTAAAGATGAA AATGGGCAGAGAAAGCAACCACTGAGAGTGAGGGAACATCCTGTTTATGGACCATATGTT GAAGCACTGTCAATGAACATTGTCAGTTCTTACGCTGATATCCAGAGTTGGCTAGAATTG GGAAATAAACAAAGAGCTACTGCTGCTACTGGTATGAATGATAAAAGTTCCCGATCTCAT TCAGTTTTCACCCTGGTGATGACCCAGACCAAGACAGAATTTGTGGAAGGGGAAGAACAC GATCACAGAATAACAAGTCGAATTAACCTAATAGATCTGGCAGGCAGTGAGCGCTGCTCT ACGGCTCACACTAATGGAGATCGACTAAAGGAAGGTGTGAGTATTAATAAGTCCTTGCTA ACTTTGGGAAAAGTTATATCTGCACTTTCGGAACAAGCAAACCAAAGGAGTGTTTTTATT CCTTATCGTGAATCTGTTCTTACATGGCTGTTAAAAGAAAGTCTGGGTGGAAATTCAAAA ACTGCAATGATTGCTACGATTAGTCCCGCTGCCAGCAACATAGAAGAAACATTAAGCACA CTTAGATATGCTAACCAAGCCCGTTTAATAGTCAACATTGCTAAAGTAAATGAAGATATG AACGCTAAGTTAATTAGAGAATTGAAGGCAGAAATTGCAAAGCTAAAAGCTGCTCAGAGA AACAGTCGGAATATTGACCCTGAACGATACAGGCTCTGTCGGCAAGAAATAACATCCTTA AGAATGAAACTGCATCAACAGGAGAGAGACATGGCAGAAATGCAAAGAGTGTGGAAAGAA AAGTTTGAACAAGCTGAAAAAAGAAAACTTCAAGAAACAAAAGAGTTACAGAAAGCAGGA ATTATGTTTCAAATGGACAATCATTTACCAAACCTTGTTAATCTGAATGAAGATCCACAA CTATCTGAGATGCTGCTATATATGATAAAAGAAGGAACAACTACAGTTGGAAAGTATAAA CCAAACTCAAGCCATGATATTCAGTTATCTGGGGTGCTGATTGCTGATGATCATTGTACT ATCAAAAATTTTGGTGGGACAGTGAGTATTATCCCAGTTGGGGAAGCAAAGACATATGTA AATGGAAAACATATTTTGGAAATCACAGTATTACGTCATGGTGATCGAGTGATTCTTGGT GGAGATCATTATTTTAGATTTAATCATCCAGTAGAAGTCCAGAAAGGAAAAAGGCCATCT GGAAGAGATACTCCTATAAGTGAGGGTCCAAAAGACTTTGAATTTGCAAAAAATGAGTTG CTCATGGCACAGAGATCACAACTTGAAGCAGAAATAAAAGAGGCTCAGTTGAAGGCAAAG GAAGAAATGATGCAAGGAATCCAGATTGCAAAAGAAATGGCTCAGCAAGAGCTTTCTTCT CAAAAAGCTGCATATGAAAGCAAAATAAAAGCACTGGAAGCAGAACTGAGAGAAGAGTCT CAAAGGAAAAAAATGCAGGAAATAAATAACCAGAAGGCTAATCACAAAATTGAGGAATTA GAAAAGGCAAAGCAGCATCTTGAACAGGAAATATATGTCAACAAAAAGCGATTAGAAATG GAAACATTGGCTACAAAACAGGCTTTAGAAGACCATAGCATCCGCCATGCAAGAATTCTG GAAGCTTTAGAAACTGAAAAGCAAAAAATTGCTAAAGAAGTACAAATTCTACAGCAGAAT CGGAATAATAGGGATAAAACTTTTACAGTGCAGACAACTTGGAGCTCTATGAAACTCTCA ATGATGATTCAGGAAGCCAATGCTATCAGCAGCAAATTGAAAACATACTATGTTTTTGGC AGACATGATATATCAGATAAAAGTAGTTCTGACACTTCTATTCGGGTTCGTAACCTGAAA CTAGGAATCTCAACATTCTGGAGTCTGGAAAAGTTTGAATCTAAACTTGCAGCAATGAAA GAACTTTATGAGAGTAATGGTAGTAACAGGGGTGAAGATGCCTTTTGTGATCCTGAAGAT GAATGGGAACCCGACATTACAGATGCACCAGTTTCTTCACTTTCTAGAAGGAGGAGTAGG AGTTTGATGAAGAACAGAAGAATTTCTGGTTGTTTACATGACATACAAGTCCATCCAATT AAGAATTTGCATTCTTCACATTCATCAGGTTTAATGGACAAATCAAGCACTATTTACTCA AATTCAGCAGAGTCCTTTCTTCCTGGAATTTGCAAAGAATTGATTGGTTCTTCGTTAGAT TTTTTTGGACAGAGTTATGATGAAGAAAGAACTATAGCAGACAGCCTAATTAATAGTTTT CTTAAAATTTATAATGGGCTATTTGCCATTTCCAAGGCTCATGAAGAACAAGATGAAGAA AGTCAAGATAACTTGTTTTCTTCTGATCGAGCAATCCAGTCACTTACTATTCAGACTGCA TGTGCTTTTGAGCAGCTAGTAGTGCTAATGAAACACTGGCTGAGTGATTTACTGCCTTGT ACCAACATAGCAAGACTTGAGGATGAGTTGAGACAAGAAGTTAAAAAACTGGGAGGCTAC TTACAGTTATTTTTGCAGGGATGCTGTTTGGATATTTCATCAATGATAAAAGAGGCTCAA AAGAATGCAATCCAAATTGTACAACAAGCTGTAAAGTATGTGGGGCAGTTAGCAGTTCTG AAAGGGAGCAAGCTACATTTTCTAGAAAACGGTAACAATAAAGCTGCCAGTGTCCAGGAG GAATTCATGGATGCTGTTTGTGATGGTGTAGGCTTAGGAATGAAGATTTTATTAGATTCT GGACTGGAAAAAGCAAAAGAACTTCAGCATGAACTCTTTAGGCAGTGTACAAAAAATGAG GTTACCAAAGAAATGAAAACTAATGCCATGGGATTGATTAGATCTCTTGAAAACATCTTT GCTGAATCGAAAATTAAAAGTTTCAGAAGGCAAGTACAAGAAGAAAACTTTGAATACCAA GATTTCAAGAGGATGGTTAATCGTGCTCCAGAATTCTTAAAGTTAAAACATTGCTTAGAG AAAGCTATTGAAATTATTATTTCTGCACTGAAAGGATGCCATAGTGATATAAATCTTCTC CAGACTTGTGTTGAAAGTATTCGCAACTTGGCCAGTGATTTTTACAGTGACTTCAGTGTG CCTTCTACTTCTGTTGGCAGCTATGAGAGTAGAGTAACTCACATTGTCCACCAGGAACTA GAATCTCTAGCTAAGTCTCTCCTCTTTTGTTTTGAATCTGAAGAAAGCCCTGATTTGTTG AAACCCTGGGAAACTTATAATCAAAATACCAAAGAAGAACACCAACAATCTAAATCAAGC GGGATTGACGGCAGTAAGAATAAAGGTGTACCAAAGCGTGTCTATGAGCTCCATGGCTCA TCCCCAGCAGTGAGCTCAGAGGAATGCACACCCAGTAGGATTCAGTGGGTGTGA |
| GenBank Gene ID | Not Available |
| GeneCard ID | Not Available |
| GenAtlas ID | Not Available |
| HGNC ID | HGNC:19181 |
| Chromosome Location | 1 |
| Locus | Not Available |
| References |
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