ATP-sensitive inward rectifier potassium channel 11

NameATP-sensitive inward rectifier potassium channel 11
Synonyms
  • IKATP
  • Inward rectifier K(+) channel Kir6.2
  • Potassium channel, inwardly rectifying subfamily J member 11
Gene NameKCNJ11
OrganismHuman
Amino acid sequence
>lcl|BSEQ0001412|ATP-sensitive inward rectifier potassium channel 11
MLSRKGIIPEEYVLTRLAEDPAEPRYRARQRRARFVSKKGNCNVAHKNIREQGRFLQDVF
TTLVDLKWPHTLLIFTMSFLCSWLLFAMAWWLIAFAHGDLAPSEGTAEPCVTSIHSFSSA
FLFSIEVQVTIGFGGRMVTEECPLAILILIVQNIVGLMINAIMLGCIFMKTAQAHRRAET
LIFSKHAVIALRHGRLCFMLRVGDLRKSMIISATIHMQVVRKTTSPEGEVVPLHQVDIPM
ENGVGGNSIFLVAPLIIYHVIDANSPLYDLAPSDLHHHQDLEIIVILEGVVETTGITTQA
RTSYLADEILWGQRFVPIVAEEDGRYSVDYSKFGNTIKVPTPLCTARQLDEDHSLLEALT
LASARGPLRKRSVPMAKAKPKFSISPDSLS
Number of residues390
Molecular Weight43540.375
Theoretical pI8.1
GO Classification
Functions
  • voltage-gated potassium channel activity
  • ATP-activated inward rectifier potassium channel activity
  • ankyrin binding
  • ion channel binding
  • potassium ion binding
  • ATP binding
Processes
  • regulation of insulin secretion
  • regulation of ion transmembrane transport
  • potassium ion transmembrane transport
  • response to drug
  • potassium ion import
  • cellular response to glucose stimulus
  • cellular response to nicotine
  • positive regulation of cation channel activity
  • synaptic transmission
  • response to ischemia
  • small molecule metabolic process
  • response to testosterone
  • glucose metabolic process
  • regulation of membrane potential
  • negative regulation of insulin secretion
  • transmembrane transport
  • cellular response to tumor necrosis factor
  • response to ATP
  • response to estradiol
  • energy reserve metabolic process
  • neurological system process
Components
  • endoplasmic reticulum
  • endosome
  • ATP-sensitive potassium channel complex
  • cell body fiber
  • plasma membrane
  • nuclear envelope
  • voltage-gated potassium channel complex
  • intercalated disc
  • T-tubule
  • cytosol
  • neuronal cell body
  • myelin sheath
  • integral component of plasma membrane
  • axolemma
  • mitochondrion
General FunctionVoltage-gated potassium channel activity
Specific FunctionThis receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium (By similarity). Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with ABCC9. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation.
Pfam Domain Function
Transmembrane Regions69-93 145-166
GenBank Protein ID1088445
UniProtKB IDQ14654
UniProtKB Entry NameKCJ11_HUMAN
Cellular LocationMembrane
Gene sequence
>lcl|BSEQ0001411|1173 bp
ATGCTGTCCCGCAAGGGCATCATCCCCGAGGAATACGTGCTGACACGCCTGGCAGAGGAC
CCTGCCGAGCCCAGGTACCGTGCCCGCCAGCGGAGGGCCCGCTTTGTGTCCAAGAAAGGC
AACTGCAACGTGGCCCACAAGAACATCCGGGAGCAGGGCCGCTTCCTGCAGGACGTGTTC
ACCACGCTGGTGGACCTCAAGTGGCCACACACATTGCTCATCTTCACCATGTCCTTCCTG
TGCAGCTGGCTGCTCTTCGCCATGGCCTGGTGGCTCATCGCCTTCGCCCACGGTGACCTG
GCCCCCAGCGAGGGCACTGCTGAGCCCTGTGTCACCAGCATCCACTCCTTCTCGTCTGCC
TTCCTTTTCTCCATTGAGGTCCAAGTGACTATTGGCTTTGGGGGGCGCATGGTGACTGAG
GAGTGCCCACTGGCCATCCTGAGCCTCATCGTGCAGAACATCGTGGGGCTCATGATCAAC
GCCATCATGCTTGGCTGCATCTTCATGAAGACTGCCCAAGCCCACCGCAGGGCTGAGACC
CTCATCTTCAGCAAGCATGCGGTGATCGCTCTGCGCCACGGCCGCCTCTGCTTCATGCTA
CGTGTGGGTGACCTCCGCAAGAGCATGATCATCAGCGCCACCATCCACATGCAGGTGGTA
CGCAAGACCACCAGCCCCGAGGGCGAGGTGGTGCCCCTCCACCAGGTGGACATCCCCATG
GAGAACGGCGTGGGTGGCAACAGCATCTTCCTGGTGGCCCCGCTGATCATCTACCATGTC
ATTGATGCCAACAGCCCACTCTACGACCTGGCACCCAGCGACCTGCACCACCACCAGGAC
CTCGAGATCATCGTCATCCTGGAAGGCGTGGTGGAAACCACGGGCATCACCACCCAGGCC
CGCACCTCCTACCTGGCCGATGAGATCCTGTGGGGCCAGCGCTTTGTGCCCATTGTAGCT
GAGGAGGACGGACGTTACTCTGTGGACTACTCCAAGTTTGGCAACACCATCAAAGTGCCC
ACACCACTCTGCACGGCCCGCCAGCTTGATGAGGACCACAGCCTACTGGAAGCTCTGACC
CTCGCCTCAGCCCGCGGGCCCCTGCGCAAGCGCAGCGTGCCCATGGCCAAGGCCAAGCCC
AAGTTCAGCATCTCTCCAGATTCCCTGTCCTGA
GenBank Gene IDD50582
GeneCard IDNot Available
GenAtlas IDKCNJ11
HGNC IDHGNC:6257
Chromosome LocationNot Available
Locus11p15.1
References
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