Hepatocyte nuclear factor 4-gamma

NameHepatocyte nuclear factor 4-gamma
Synonyms
  • HNF-4-gamma
  • NR2A2
  • Nuclear receptor subfamily 2 group A member 2
Gene NameHNF4G
OrganismHuman
Amino acid sequence
>lcl|BSEQ0037221|Hepatocyte nuclear factor 4-gamma
MNTTDNGVNCLCAICGDRATGKHYGASSCDGCKGFFRRSIRKSHVYSCRFSRQCVVDKDK
RNQCRYCRLRKCFRAGMKKEAVQNERDRISTRRSTFDGSNIPSINTLAQAEVRSRQISVS
SPGSSTDINVKKIASIGDVCESMKQQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHL
LLGATKRSMMYKDILLLGNNYVIHRNSCEVEISRVANRVLDELVRPFQEIQIDDNEYACL
KAIVFFDPDAKGLSDPVKIKNMRFQVQIGLEDYINDRQYDSRGRFGELLLLLPTLQSITW
QMIEQIQFVKLFGMVKIDNLLQEMLLGGASNDGSHLHHPMHPHLSQDPLTGQTILLGPMS
TLVHADQISTPETPLPSPPQGSGQEQYKIAANQASVISHQHLSKQKQL
Number of residues408
Molecular Weight45876.235
Theoretical pI8.43
GO Classification
Functions
  • transcription factor activity, sequence-specific DNA binding
  • RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
  • zinc ion binding
  • steroid hormone receptor activity
  • sequence-specific DNA binding
Processes
  • gene expression
  • transcription initiation from RNA polymerase II promoter
  • regulation of transcription from RNA polymerase II promoter
  • endocrine pancreas development
Components
  • nucleoplasm
General FunctionZinc ion binding
Specific FunctionTranscription factor. Has a lower transcription activation potential than HNF4-alpha.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDQ14541
UniProtKB Entry NameHNF4G_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0020665|Hepatocyte nuclear factor 4-gamma (HNF4G)
ATGGACATGGCAAATTACAGTGAAGTTTTGGACCCAACTTACACAACTTTGGAGTTTGAA
ACTATGCAGATTCTATATAATTCAAGTGATAGTTCTGCCCCAGAGACAAGTATGAATACC
ACAGACAACGGTGTCAACTGTCTGTGTGCTATCTGTGGGGACAGAGCAACAGGAAAACAC
TATGGGGCATCCAGCTGTGATGGGTGCAAGGGTTTCTTCAGACGCAGCATTCGTAAGAGT
CACGTTTATTCTTGCAGGTTCAGTCGGCAATGTGTTGTTGACAAGGACAAAAGGAATCAA
TGTAGATATTGTCGATTAAGAAAGTGTTTTAGAGCGGGAATGAAAAAAGAAGCTGTACAA
AATGAACGTGACAGAATAAGCACCAGAAGAAGCACATTTGATGGCAGCAACATCCCCTCC
ATTAACACACTGGCACAAGCTGAAGTTCGGTCTCGCCAGATCTCAGTCTCAAGCCCTGGG
TCAAGCACTGACATAAACGTTAAGAAAATTGCAAGTATTGGTGATGTCTGTGAATCTATG
AAACAGCAGCTCTTAGTCTTGGTGGAATGGGCTAAATATATTCCTGCCTTCTGTGAATTA
CCATTGGATGATCAGGTGGCACTGTTGAGAGCTCACGCAGGGGAGCACTTACTGCTTGGA
GCTACAAAGAGATCCATGATGTATAAAGATATTTTGCTTTTGGGAAACAACTATGTTATT
CACCGCAACAGCTGTGAAGTTGAGATTAGCCGTGTGGCCAATCGTGTTCTAGATGAGCTG
GTTAGACCATTTCAAGAAATCCAGATTGATGACAATGAGTATGCTTGTTTAAAGGCAATT
GTATTTTTTGATCCAGATGCAAAAGGGCTAAGCGATCCAGTAAAAATTAAGAACATGAGG
TTCCAAGTGCAGATCGGTTTGGAGGACTACATCAATGATCGGCAGTATGACTCCCGGGGG
AGGTTTGGAGAGTTGCTTCTGCTCCTGCCCACACTGCAGAGCATCACGTGGCAAATGATT
GAGCAAATACAGTTTGTTAAACTTTTTGGGATGGTTAAAATTGACAATCTACTTCAGGAA
ATGCTATTAGGTGGGGCTTCCAATGATGGCAGTCATCTCCATCATCCAATGCATCCACAT
TTGTCTCAAGACCCATTAACTGGACAAACTATACTTTTAGGTCCCATGTCAACACTGGTT
CATGCAGACCAGATCTCAACTCCTGAAACCCCACTCCCTTCCCCACCACAAGGCTCTGGG
CAAGAACAGTACAAAATAGCTGCAAACCAAGCATCAGTCATTTCACACCAGCATCTCTCC
AAACAAAAGCAATTGTGA
GenBank Gene IDZ49826
GeneCard IDNot Available
GenAtlas IDHNF4G
HGNC IDHGNC:5026
Chromosome Location8
Locus8q21.11
References
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  3. Plengvidhya N, Antonellis A, Wogan LT, Poleev A, Borgschulze M, Warram JH, Ryffel GU, Krolewski AS, Doria A: Hepatocyte nuclear factor-4gamma: cDNA sequence, gene organization, and mutation screening in early-onset autosomal-dominant type 2 diabetes. Diabetes. 1999 Oct;48(10):2099-102. 10512380
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