Guanidinoacetate N-methyltransferase

NameGuanidinoacetate N-methyltransferase
Synonyms
  • 2.1.1.2
Gene NameGAMT
OrganismHuman
Amino acid sequence
>lcl|BSEQ0001132|Guanidinoacetate N-methyltransferase
MSAPSATPIFAPGENCSPAWGAAPAAYDAADTHLRILGKPVMERWETPYMHALAAAASSK
GGRVLEVGFGMAIAASKVQEAPIDEHWIIECNDGVFQRLRDWAPRQTHKVIPLKGLWEDV
APTLPDGHFDGILYDTYPLSEETWHTHQFNFIKNHAFRLLKPGGVLTYCNLTSWGELMKS
KYSDITIMFEETQVPALLEAGFRRENIRTEVMALVPPADCRYYAFPQMITPLVTKG
Number of residues236
Molecular Weight26317.925
Theoretical pI6.09
GO Classification
Functions
  • methyltransferase activity
  • guanidinoacetate N-methyltransferase activity
Processes
  • S-adenosylhomocysteine metabolic process
  • cellular nitrogen compound metabolic process
  • small molecule metabolic process
  • polyamine metabolic process
  • S-adenosylmethionine metabolic process
  • regulation of multicellular organism growth
  • creatine metabolic process
  • organ morphogenesis
  • creatine biosynthetic process
  • embryonic liver development
  • muscle contraction
  • spermatogenesis
Components
  • cytoplasm
  • nucleus
  • cytosol
  • extracellular exosome
General FunctionMethyltransferase activity
Specific FunctionNot Available
Pfam Domain FunctionNot Available
Transmembrane RegionsNot Available
GenBank Protein ID1212946
UniProtKB IDQ14353
UniProtKB Entry NameGAMT_HUMAN
Cellular LocationNot Available
Gene sequence
>lcl|BSEQ0016138|Guanidinoacetate N-methyltransferase (GAMT)
ATGAGCGCCCCCAGCGCGACCCCCATCTTCGCGCCCGGCGAGAACTGCAGCCCCGCGTGG
GGGGCGGCGCCCGCGGCCTACGACGCAGCGGACACGCACCTGCGCATCCTGGGCAAGCCG
GTGATGGAGCGCTGGGAGACCCCCTATATGCACGCGCTGGCCGCCGCCGCCTCCTCCAAA
GGGGGCCGGGTCCTGGAGGTGGGCTTTGGCATGGCCATCGCAGCGTCAAAGGTGCAGGAG
GCGCCCATTGATGAGCATTGGATCATCGAGTGCAATGACGGCGTCTTCCAGCGGCTCCGG
GACTGGGCCCCACGGCAGACACACAAGGTCATCCCCTTGAAAGGCCTGTGGGAGGATGTG
GCACCCACCCTGCCTGACGGTCACTTTGATGGGATCCTGTACGACACGTACCCACTCTCG
GAGGAGACCTGGCACACACACCAGTTCAACTTCATCAAGAACCACGCCTTTCGCCTGCTG
AAGCCGGGGGGCGTCCTCACCTACTGCAACCTCACCTCCTGGGGGGAGCTGATGAAGTCC
AAGTACTCAGACATCACCATCATGTTTGAGGAGACGCAGGTGCCCGCGCTGCTGGAGGCC
GGCTTCCGGAGGGAGAACATCCGTACGGAGGTGATGGCGCTGGTCCCACCGGCCGACTGC
CGCTACTACGCCTTCCCACAGATGATCACGCCCCTGGTGACCAAAGGCTGA
GenBank Gene IDZ49878
GeneCard IDNot Available
GenAtlas IDGAMT
HGNC IDHGNC:4136
Chromosome Location19
Locus19p13.3
References
  1. Isbrandt D, von Figura K: Cloning and sequence analysis of human guanidinoacetate N-methyltransferase cDNA. Biochim Biophys Acta. 1995 Dec 27;1264(3):265-7. 8547310
  2. Jenne DE, Olsen AS, Zimmer M: The human guanidinoacetate methyltransferase (GAMT) gene maps to a syntenic region on 19p13.3, homologous to band C of mouse chromosome 10, but GAMT is not mutated in jittery mice. Biochem Biophys Res Commun. 1997 Sep 29;238(3):723-7. 9325156
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