NameGuanine nucleotide-binding protein subunit alpha-13
Synonyms
  • G alpha-13
Gene NameGNA13
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009112|Guanine nucleotide-binding protein subunit alpha-13
MADFLPSRSVLSVCFPGCLLTSGEAEQQRKSKEIDKCLSREKTYVKRLVKILLLGAGESG
KSTFLKQMRIIHGQDFDQRAREEFRPTIYSNVIKGMRVLVDAREKLHIPWGDNSNQQHGD
KMMSFDTRAPMAAQGMVETRVFLQYLPAIRALWADSGIQNAYDRRREFQLGESVKYFLDN
LDKLGEPDYIPSQQDILLARRPTKGIHEYDFEIKNVPFKMVDVGGQRSERKRWFECFDSV
TSILFLVSSSEFDQVLMEDRLTNRLTESLNIFETIVNNRVFSNVSIILFLNKTDLLEEKV
QIVSIKDYFLEFEGDPHCLRDVQKFLVECFRNKRRDQQQKPLYHHFTTAINTENIRLVFR
DVKDTILHDNLKQLMLQ
Number of residues377
Molecular Weight44049.2
Theoretical pINot Available
GO Classification
Functions
  • G-protein beta/gamma-subunit complex binding
  • D5 dopamine receptor binding
  • type 1 angiotensin receptor binding
  • signal transducer activity
  • GTP binding
  • GTPase activity
  • metal ion binding
Processes
  • regulation of cell shape
  • platelet activation
  • regulation of cell migration
  • in utero embryonic development
  • cell differentiation
  • positive regulation of cytosolic calcium ion concentration
  • Rho protein signal transduction
  • signal transduction
  • movement of cell or subcellular component
  • adenylate cyclase-activating G-protein coupled receptor signaling pathway
  • blood coagulation
  • patterning of blood vessels
  • activation of phospholipase D activity
Components
  • cytosol
  • extracellular exosome
  • cytoplasm
  • membrane
  • brush border membrane
  • focal adhesion
  • nucleus
  • melanosome
  • plasma membrane
  • heterotrimeric G-protein complex
General FunctionType 1 angiotensin receptor binding
Specific FunctionGuanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDQ14344
UniProtKB Entry NameGNA13_HUMAN
Cellular LocationMembrane
Gene sequence
>lcl|BSEQ0021438|Guanine nucleotide-binding protein subunit alpha-13 (GNA13)
ATGAGGGTGCTGGTTGATGCTCGAGAGAAGCTTCATATTCCCTGGGGAGACAACTCAAAC
CAACAACATGGAGATAAGATGATGTCGTTTGATACCCGGGCCCCCATGGCAGCCCAAGGA
ATGGTGGAAACAAGGGTTTTCTTACAATATCTTCCTGCTATAAGAGCATTATGGGCAGAC
AGCGGCATACAGAATGCCTATGACCGGCGTCGAGAATTTCAACTGGGTGAATCTGTAAAA
TATTTCCTGGATAACTTGGATAAACTTGGAGAACCAGATTATATTCCATCACAACAAGAT
ATTCTGCTTGCCAGAAGACCCACCAAAGGCATCCATGAATACGACTTTGAAATAAAAAAT
GTTCCTTTCAAAATGGTTGATGTAGGTGGTCAGAGATCAGAAAGGAAACGTTGGTTTGAA
TGTTTCGACAGTGTGACATCAATACTTTTCCTTGTTTCCTCAAGTGAATTTGACCAGGTG
CTTATGGAAGATCGACTGACCAATCGCCTTACAGAGTCTCTGAACATTTTTGAAACAATC
GTCAATAACCGGGTTTTCAGCAATGTCTCCATAATTCTGTTCTTAAACAAGACAGACTTG
CTTGAGGAGAAGGTGCAAATTGTGAGCATCAAAGACTATTTCCTAGAATTTGAAGGGGAT
CCCCACTGCTTAAGAGACGTCCAAAAATTCCTGGTGGAATGTTTCCGGAACAAACGCCGG
GACCAGCAACAGAAGCCCTTATACCACCACTTCACCACTGCTATCAACACGGAGAACATC
CGCCTTGTTTTCCGTGACGTGAAGGATACTATTCTGCATGACAACCTCAAGCAGCTTATG
CTACAGTGA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:4381
Chromosome Location17
LocusNot Available
References
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  5. Manganello JM, Huang JS, Kozasa T, Voyno-Yasenetskaya TA, Le Breton GC: Protein kinase A-mediated phosphorylation of the Galpha13 switch I region alters the Galphabetagamma13-G protein-coupled receptor complex and inhibits Rho activation. J Biol Chem. 2003 Jan 3;278(1):124-30. Epub 2002 Oct 23. 12399457
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  7. Tateiwa K, Katoh H, Negishi M: Socius, a novel binding partner of Galpha12/13, promotes the Galpha12-induced RhoA activation. Biochem Biophys Res Commun. 2005 Nov 18;337(2):615-20. Epub 2005 Sep 23. 16202387
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