NameSodium/potassium-transporting ATPase subunit alpha-4
Synonyms
  • 3.6.3.9
  • ATP1AL2
  • Na(+)/K(+) ATPase alpha-4 subunit
  • Sodium pump subunit alpha-4
Gene NameATP1A4
OrganismHuman
Amino acid sequence
>lcl|BSEQ0008798|Sodium/potassium-transporting ATPase subunit alpha-4
MGLWGKKGTVAPHDQSPRRRPKKGLIKKKMVKREKQKRNMEELKKEVVMDDHKLTLEELS
TKYSVDLTKGHSHQRAKEILTRGGPNTVTPPPTTPEWVKFCKQLFGGFSLLLWTGAILCF
VAYSIQIYFNEEPTKDNLYLSIVLSVVVIVTGCFSYYQEAKSSKIMESFKNMVPQQALVI
RGGEKMQINVQEVVLGDLVEIKGGDRVPADLRLISAQGCKVDNSSLTGESEPQSRSPDFT
HENPLETRNICFFSTNCVEGTARGIVIATGDSTVMGRIASLTSGLAVGQTPIAAEIEHFI
HLITVVAVFLGVTFFALSLLLGYGWLEAIIFLIGIIVANVPEGLLATVTVCLTLTAKRMA
RKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDMTVYEADTTEEQTGKTFT
KSSDTWFMLARIAGLCNRADFKANQEILPIAKRATTGDASESALLKFIEQSYSSVAEMRE
KNPKVAEIPFNSTNKYQMSIHLREDSSQTHVLMMKGAPERILEFCSTFLLNGQEYSMNDE
MKEAFQNAYLELGGLGERVLGFCFLNLPSSFSKGFPFNTDEINFPMDNLCFVGLISMIDP
PRAAVPDAVSKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGTETAEEVAARLKIPISK
VDASAAKAIVVHGAELKDIQSKQLDQILQNHPEIVFARTSPQQKLIIVEGCQRLGAVVAV
TGDGVNDSPALKKADIGIAMGISGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKK
SIMYTLTSNIPEITPFLMFIILGIPLPLGTITILCIDLGTDMVPAISLAYESAESDIMKR
LPRNPKTDNLVNHRLIGMAYGQIGMIQALAGFFTYFVILAENGFRPVDLLGIRLHWEDKY
LNDLEDSYGQQWTYEQRKVVEFTCQTAFFVTIVVVQWADLIISKTRRNSLFQQGMRNKVL
IFGILEETLLAAFLSYTPGMDVALRMYPLKITWWLCAIPYSILIFVYDEIRKLLIRQHPD
GWVERETYY
Number of residues1029
Molecular Weight114165.44
Theoretical pINot Available
GO Classification
Functions
  • ATP binding
  • metal ion binding
  • sodium
Processes
  • transmembrane transport
  • ion transmembrane transport
  • potassium ion import
  • sperm motility
  • establishment or maintenance of transmembrane electrochemical gradient
  • sodium ion export from cell
  • regulation of membrane potential
  • spermatogenesis
  • cellular potassium ion homeostasis
  • sodium ion transport
  • ATP hydrolysis coupled proton transport
  • potassium ion transport
  • cellular sodium ion homeostasis
  • fertilization
  • regulation of cellular pH
Components
  • intracellular membrane-bounded organelle
  • sodium
  • plasma membrane
  • integral component of plasma membrane
General FunctionSodium:potassium-exchanging atpase activity
Specific FunctionThis is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. Plays a role in sperm motility.
Pfam Domain Function
Transmembrane Regions96-116 140-160 297-316 329-346 779-798 809-829 850-872 925-944 958-976 992-1012
GenBank Protein IDNot Available
UniProtKB IDQ13733
UniProtKB Entry NameAT1A4_HUMAN
Cellular LocationCell membrane
Gene sequence
>lcl|BSEQ0019665|Sodium/potassium-transporting ATPase subunit alpha-4 (ATP1A4)
ATGATCCAGGCTCTGGCTGGATTCTTTACCTACTTTGTAATCCTGGCTGAGAATGGTTTT
AGGCCTGTTGATCTGCTGGGCATCCGCCTCCACTGGGAAGATAAATACTTGAATGACCTG
GAGGACAGCTACGGACAGCAGTGGACCTATGAGCAACGAAAAGTTGTGGAGTTCACATGC
CAAACGGCCTTTTTTGTCACCATCGTGGTTGTGCAGTGGGCGGATCTCATCATCTCCAAG
ACTCGCCGCAACTCACTTTTCCAGCAGGGCATGAGAAACAAAGTCTTAATATTTGGGATC
CTGGAGGAGACACTCTTGGCTGCATTTCTGTCCTACACTCCAGGCATGGACGTGGCCCTG
CGAATGTACCCACTCAAGATAACCTGGTGGCTCTGTGCCATTCCCTACAGTATTCTCATC
TTCGTCTATGATGAAATCAGAAAACTCCTCATCCGTCAGCACCCGGATGGCTGGGTGGAA
AGGGAGACGTACTACTAA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:14073
Chromosome Location1
LocusNot Available
References
  1. Hlivko JT, Chakraborty S, Hlivko TJ, Sengupta A, James PF: The human Na,K-ATPase alpha 4 isoform is a ouabain-sensitive alpha isoform that is expressed in sperm. Mol Reprod Dev. 2006 Jan;73(1):101-15. 16175638
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  4. Keryanov S, Gardner KL: Physical mapping and characterization of the human Na,K-ATPase isoform, ATP1A4. Gene. 2002 Jun 12;292(1-2):151-66. 12119109
  5. Shamraj OI, Lingrel JB: A putative fourth Na+,K(+)-ATPase alpha-subunit gene is expressed in testis. Proc Natl Acad Sci U S A. 1994 Dec 20;91(26):12952-6. 7809153
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