NameDual specificity mitogen-activated protein kinase kinase 5
Synonyms
  • 2.7.12.2
  • MAP kinase kinase 5
  • MAPK/ERK kinase 5
  • MEK 5
  • MEK5
  • MKK5
  • PRKMK5
Gene NameMAP2K5
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009090|Dual specificity mitogen-activated protein kinase kinase 5
MLWLALGPFPAMENQVLVIRIKIPNSGAVDWTVHSGPQLLFRDVLDVIGQVLPEATTTAF
EYEDEDGDRITVRSDEEMKAMLSYYYSTVMEQQVNGQLIEPLQIFPRACKPPGERNIHGL
KVNTRAGPSQHSSPAVSDSLPSNSLKKSSAELKKILANGQMNEQDIRYRDTLGHGNGGTV
YKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSSYIIGFYGAFFVENRISIC
TEFMDGGSLDVYRKMPEHVLGRIAVAVVKGLTYLWSLKILHRDVKPSNMLVNTRGQVKLC
DFGVSTQLVNSIAKTYVGTNAYMAPERISGEQYGIHSDVWSLGISFMELALGRFPYPQIQ
KNQGSLMPLQLLQCIVDEDSPVLPVGEFSEPFVHFITQCMRKQPKERPAPEELMGHPFIV
QFNDGNAAVVSMWVCRALEERRSQQGPP
Number of residues448
Molecular Weight50111.385
Theoretical pINot Available
GO Classification
Functions
  • protein serine/threonine kinase activity
  • metal ion binding
  • protein tyrosine kinase activity
  • ATP binding
  • protein kinase activity
Processes
  • negative regulation of heterotypic cell-cell adhesion
  • negative regulation of NF-kappaB transcription factor activity
  • cellular response to laminar fluid shear stress
  • ERK5 cascade
  • negative regulation of cell migration involved in sprouting angiogenesis
  • heart development
  • negative regulation of chemokine (C-X-C motif) ligand 2 production
  • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
  • negative regulation of response to cytokine stimulus
  • neurotrophin TRK receptor signaling pathway
  • positive regulation of protein metabolic process
  • positive regulation of transcription from RNA polymerase II promoter
  • positive regulation of cell growth
  • negative regulation of transcription from RNA polymerase II promoter
  • positive regulation of epithelial cell proliferation
  • activation of MAPK activity
  • signal transduction
  • cellular response to growth factor stimulus
  • negative regulation of interleukin-8 biosynthetic process
  • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
Components
  • spindle
  • nucleus
  • cytosol
General FunctionProtein tyrosine kinase activity
Specific FunctionActs as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDQ13163
UniProtKB Entry NameMP2K5_HUMAN
Cellular LocationNot Available
Gene sequence
>lcl|BSEQ0013606|Dual specificity mitogen-activated protein kinase kinase 5 (MAP2K5)
ATGATGGAGGGTCACTTTCCCCAGAGCGATGTGATAGGCCAGGTTCTGCCTGAAGCAACA
ACTACAGCATTTGAATATGAAGATGAAGATGGTGATCGAATTACAGTGAGAAGTGATGAG
GAAATGAAGGCAATGCTGTCATATTATTATTCCACAGTAATGGAACAGCAAGTAAATGGA
CAGTTAATAGAGCCTCTGCAGATATTTCCAAGAGCCTGCAAGCCTCCTGGGGAACGGAAC
ATACATGGCCTGAAGGTGAATACTCGGGCCGGACCCTCTCAACACAGCAGCCCAGCAGTC
TCAGATTCACTTCCAAGCAATAGCTTAAAGAAGTCTTCTGCTGAACTGAAAAAAATACTA
GCCAATGGCCAGATGAATGAACAAGACATACGATATCGGGACACTCTTGGTCATGGCAAC
GGAGGCACAGTCTACAAAGCATATCATGTCCCGAGTGGGAAAATATTAGCTGTAAAGGTC
ATACTACTAGATATTACACTGGAACTTCAGAAGCAAATTATGTCTGAATTGGAAATTCTT
TATAAGTGCGATTCATCATATATCATTGGATTTTATGGAGCATTTTTTGTAGAAAACAGG
ATTTCAATATGTACAGAATTCATGGATGGGGGATCTTTGGATGTATATAGGAAAATGCCA
GAACATGTCCTTGGAAGAATTGCAGTAGCAGTTGTTAAAGGCCTTACTTATTTGTGGAGT
TTAAAGATTTTACATAGAGACGTGAAGCCCTCCAATATGCTAGTAAACACAAGAGGACAG
GTTAAGCTGTGTGATTTTGGAGTTAGCACTCAGCTGGTGAATTCTATAGCCAAGACGTAT
GTTGGAACAAATGCTTATATGGCGCCTGAAAGGATTTCAGGGGAGCAGTATGGAATTCAT
TCTGATGTCTGGAGCTTAGGAATCTCTTTTATGGAGCTTGCTCTTGGGAGGTTTCCATAT
CCTCAGATTCAGAAAAACCAGGGATCTTTAATGCCTCTCCAGCTTCTGCAGTGCATTGTT
GATGAGGATTCGCCCGTCCTTCCAGTTGGAGAGTTCTCGGAGCCATTTGTACATTTCATC
ACTCAGTGTATGCGAAAACAGCCAAAAGAAAGGCCAGCACCTGAAGAATTGATGGGCCAC
CCGTTCATCGTGCAGTTCAATGATGGAAATGCCGCCGTGGTGTCCATGTGGGTGTGCCGG
GCGCTGGAGGAGAGGCGGAGCCAGCAGGGGCCCCCGTGA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:6845
Chromosome Location15
LocusNot Available
References
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