Glutamate receptor ionotropic, kainate 3

NameGlutamate receptor ionotropic, kainate 3
Synonyms
  • EAA5
  • Excitatory amino acid receptor 5
  • GluK3
  • GluR-7
  • GLUR7
  • Glutamate receptor 7
Gene NameGRIK3
OrganismHuman
Amino acid sequence
>lcl|BSEQ0037089|Glutamate receptor ionotropic, kainate 3
MTAPWRRLRSLVWEYWAGLLVCAFWIPDSRGMPHVIRIGGIFEYADGPNAQVMNAEEHAF
RFSANIINRNRTLLPNTTLTYDIQRIHFHDSFEATKKACDQLALGVVAIFGPSQGSCTNA
VQSICNALEVPHIQLRWKHHPLDNKDTFYVNLYPDYASLSHAILDLVQYLKWRSATVVYD
DSTGLIRLQELIMAPSRYNIRLKIRQLPIDSDDSRPLLKEMKRGREFRIIFDCSHTMAAQ
ILKQAMAMGMMTEYYHFIFTTLDLYALDLEPYRYSGVNLTGFRILNVDNPHVSAIVEKWS
MERLQAAPRSESGLLDGVMMTDAALLYDAVHIVSVCYQRAPQMTVNSLQCHRHKAWRFGG
RFMNFIKEAQWEGLTGRIVFNKTSGLRTDFDLDIISLKEDGLEKVGVWSPADGLNITEVA
KGRGPNVTDSLTNRSLIVTTVLEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFS
YEIRLVEDGKYGAQDDKGQWNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGV
SILYRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPYEWYDAHPCNPG
SEVVENNFTLLNSFWFGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAF
LTVERMESPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFMSSKPSALVK
NNEEGIQRALTADYALLMESTTIEYVTQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKIT
IAILQLQEEDKLHIMKEKWWRGSGCPEEENKEASALGIQKIGGIFIVLAAGLVLSVLVAV
GEFVYKLRKTAEREQRSFCSTVADEIRFSLTCQRRVKHKPQPPMMVKTDAVINMHTFNDR
RLPGKDSMACSTSLAPVFP
Number of residues919
Molecular Weight104036.06
Theoretical pI7.69
GO Classification
Functions
  • adenylate cyclase inhibiting G-protein coupled glutamate receptor activity
  • extracellular-glutamate-gated ion channel activity
  • kainate selective glutamate receptor activity
  • glutamate receptor activity
  • ionotropic glutamate receptor activity
Processes
  • G-protein coupled glutamate receptor signaling pathway
  • ion transmembrane transport
  • adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway
  • regulation of membrane potential
  • negative regulation of synaptic transmission, glutamatergic
  • glutamate receptor signaling pathway
  • synaptic transmission, glutamatergic
  • ionotropic glutamate receptor signaling pathway
  • synaptic transmission
Components
  • cell junction
  • dendrite cytoplasm
  • integral component of plasma membrane
  • dendrite
  • perikaryon
  • presynaptic membrane
  • terminal bouton
  • axon
  • kainate selective glutamate receptor complex
  • postsynaptic membrane
  • plasma membrane
General FunctionKainate selective glutamate receptor activity
Specific FunctionReceptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds domoate > kainate >> L-glutamate = quisqualate >> AMPA = NMDA.
Pfam Domain Function
Transmembrane Regions564-584 637-657 821-841
GenBank Protein ID790534
UniProtKB IDQ13003
UniProtKB Entry NameGRIK3_HUMAN
Cellular LocationCell membrane
Gene sequence
>lcl|BSEQ0010587|Glutamate receptor ionotropic, kainate 3 (GRIK3)
ATGACCGCTCCCTGGCGGCGCCTCCGGAGTCTGGTTTGGGAATACTGGGCCGGGCTCCTC
GTGTGCGCCTTCTGGATCCCGGACTCGCGCGGGATGCCCCACGTCATCCGGATCGGAGGA
ATCTTCGAGTATGCGGACGGCCCCAACGCCCAGGTCATGAATGCCGAGGAGCATGCCTTT
CGATTTTCTGCCAACATCATCAACAGGAACAGGACTCTGCTGCCCAACACAACCTTGACC
TATGACATACAGAGGATTCACTTCCATGACAGCTTCGAGGCGACCAAAAAGGCCTGTGAC
CAGCTGGCACTGGGCGTGGTGGCGATCTTCGGCCCATCACAGGGCTCCTGCACCAATGCC
GTCCAGTCCATCTGCAATGCCCTGGAGGTGCCCCACATCCAGCTGCGTTGGAAGCACCAC
CCGCTGGACAACAAGGACACCTTCTACGTGAACCTCTACCCCGACTACGCCTCGCTCAGC
CATGCCATCCTCGACCTGGTCCAGTACCTCAAGTGGCGGTCAGCCACCGTGGTCTATGAC
GACAGTACAGGGCTCATCCGACTGCAGGAGCTCATCATGGCCCCATCAAGATACAACATC
CGCCTGAAGATCCGTCAGCTCCCCATCGACTCTGACGACTCGCGCCCCTTGCTCAAGGAG
ATGAAGCGAGGCCGGGAATTCCGCATTATCTTCGACTGCAGCCACACTATGGCGGCCCAG
ATCCTCAAGCAGGCCATGGCCATGGGCATGATGACTGAGTACTACCACTTCATCTTCACC
ACTCTGGATCTCTACGCTTTAGACCTGGAGCCCTACCGCTACTCAGGCGTGAACCTGACA
GGATTCCGGATTCTCAATGTGGACAACCCACACGTCTCGGCCATTGTGGAGAAGTGGTCC
ATGGAGCGGCTGCAGGCAGCTCCCCGGTCCGAGTCTGGCCTGCTGGATGGAGTGATGATG
ACTGATGCAGCCTTACTGTACGACGCCGTCCATATCGTGTCCGTGTGCTACCAGCGGGCA
CCACAGATGACCGTGAACTCCCTGCAGTGCCATCGGCACAAGGCCTGGCGCTTTGGCGGC
CGCTTCATGAACTTCATCAAGGAGGCTCAATGGGAAGGATTAACTGGACGAATTGTTTTC
AACAAAACTAGTGGCTTGCGGACGGATTTTGATCTGGACATCATCAGCCTGAAAGAGGAT
GGCCTGGAGAAGGTTGGGGTGTGGAGTCCTGCCGACGGGCTCAACATCACTGAGGTTGCC
AAAGGCCGAGGCCCTAATGTCACCGACTCTCTGACAAACAGATCACTCATTGTCACCACA
GTGCTGGAGGAGCCCTTCGTCATGTTTCGGAAATCAGACAGGACGCTATACGGGAATGAC
CGGTTCGAGGGCTACTGCATCGACCTGCTAAAGGAGCTGGCCCACATCCTTGGTTTCTCC
TATGAGATCCGGCTGGTGGAGGACGGCAAGTACGGGGCACAGGATGACAAGGGCCAGTGG
AACGGCATGGTCAAGGAGCTCATCGACCACAAGGCAGATCTGGCCGTGGCCCCCCTGACC
ATCACCCATGTTCGAGAGAAGGCCATCGACTTCTCCAAGCCCTTCATGACACTTGGTGTG
AGCATCCTGTATCGAAAGCCCAATGGCACCAACCCCAGCGTCTTCTCCTTCCTCAATCCC
CTGTCCCCAGACATCTGGATGTATGTTCTCCTCGCCTACCTGGGGGTCAGCTGTGTCCTC
TTCGTCATCGCCAGGTTCAGCCCTTATGAGTGGTACGATGCTCACCCCTGCAACCCTGGC
TCCGAGGTGGTGGAAAATAACTTCACTCTGCTTAACAGCTTCTGGTTTGGAATGGGATCC
CTGATGCAGCAAGGGTCTGAGCTGATGCCCAAAGCCCTGTCCACACGCATCATTGGTGGC
ATCTGGTGGTTCTTCACGCTCATCATCATCTCTTCCTACACGGCCAACCTGGCTGCCTTT
CTGACCGTGGAGCGCATGGAATCACCCATTGACTCTGCTGATGACCTGGCCAAGCAAACC
AAAATCGAGTATGGGGCTGTCAAGGATGGGGCCACCATGACCTTCTTCAAGAAATCCAAG
ATCTCCACCTTCGAGAAGATGTGGGCCTTCATGAGCAGCAAGCCATCGGCGCTGGTGAAG
AACAACGAGGAGGGCATCCAGAGGGCCCTGACGGCCGACTACGCGCTGCTCATGGAGTCC
ACCACCATCGAGTACGTCACGCAGAGGAACTGCAACCTCACCCAGATCGGGGGCCTCATT
GACTCCAAGGGCTACGGCATCGGCACGCCCATGGGCTCCCCATACCGGGACAAGATCACC
ATCGCCATCCTGCAGCTTCAGGAGGAGGACAAGCTGCATATCATGAAGGAGAAGTGGTGG
CGGGGCAGCGGGTGTCCTGAGGAGGAAAACAAAGAGGCCAGTGCCCTGGGGATCCAGAAG
ATCGGGGGCATCTTCATTGTCCTGGCCGCCGGGCTGGTCCTCTCTGTGCTGGTGGCCGTG
GGCGAGTTTGTGTACAAGCTCCGCAAAACAGCAGAGAGAGAGCAGCGTTCCTTCTGCAGC
ACCGTGGCCGATGAGATCCGTTTCTCCCTTACCTGCCAGCGTCGAGTCAAGCACAAGCCT
CAGCCTCCCATGATGGTCAAGACTGACGCCGTCATCAACATGCACACATTCAATGACCGC
CGGCTTCCCGGCAAGGACAGCATGGCCTGCAGCACATCCTTAGCCCCTGTGTTCCCCTAG
GenBank Gene IDU16127
GeneCard IDNot Available
GenAtlas IDGRIK3
HGNC IDHGNC:4581
Chromosome Location1
Locus1p34-p33
References
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