T3DB: Sterol regulatory element-binding protein 2

Name	Sterol regulatory element-binding protein 2
Synonyms	BHLHD2 Class D basic helix-loop-helix protein 2 SREBP-2 SREBP2 Sterol regulatory element-binding transcription factor 2
Gene Name	SREBF2
Organism	Human
Amino acid sequence	>lcl\|BSEQ0037297\|Sterol regulatory element-binding protein 2 MDDSGELGGLETMETLTELGDELTLGDIDEMLQFVSNQVGEFPDLFSEQLCSSFPGSGGS GSSSGSSGSSSSSSNGRGSSSGAVDPSVQRSFTQVTLPSFSPSAASPQAPTLQVKVSPTS VPTTPRATPILQPRPQPQPQPQTQLQQQTVMITPTFSTTPQTRIIQQPLIYQNAATSFQV LQPQVQSLVTSSQVQPVTIQQQVQTVQAQRVLTQTANGTLQTLAPATVQTVAAPQVQQVP VLVQPQIIKTDSLVLTTLKTDGSPVMAAVQNPALTALTTPIQTAALQVPTLVGSSGTILT TMPVMMGQEKVPIKQVPGGVKQLEPPKEGERRTTHNIIEKRYRSSINDKIIELKDLVMGT DAKMHKSGVLRKAIDYIKYLQQVNHKLRQENMVLKLANQKNKLLKGIDLGSLVDNEVDLK IEDFNQNVLLMSPPASDSGSQAGFSPYSIDSEPGSPLLDDAKVKDEPDSPPVALGMVDRS RILLCVLTFLCLSFNPLTSLLQWGGAHDSDQHPHSGSGRSVLSFESGSGGWFDWMMPTLL LWLVNGVIVLSVFVKLLVHGEPVIRPHSRSSVTFWRHRKQADLDLARGDFAAAAGNLQTC LAVLGRALPTSRLDLACSLSWNVIRYSLQKLRLVRWLLKKVFQCRRATPATEAGFEDEAK TSARDAALAYHRLHQLHITGKLPAGSACSDVHMALCAVNLAECAEEKIPPSTLVEIHLTA AMGLKTRCGGKLGFLASYFLSRAQSLCGPEHSAVPDSLRWLCHPLGQKFFMERSWSVKSA AKESLYCAQRNPADPIAQVHQAFCKNLLERAIESLVKPQAKKKAGDQEEESCEFSSALEY LKLLHSFVDSVGVMSPPLSRSSVLKSALGPDIICRWWTSAITVAISWLQGDDAAVRSHFT KVERIPKALEVTESPLVKAIFHACRAMHASLPGKADGQQSSFCHCERASGHLWSSLNVSG ATSDPALNHVVQLLTCDLLLSLRTALWQKQASASQAVGETYHASGAELAGFQRDLGSLRR LAHSFRPAYRKVFLHEATVRLMAGASPTRTHQLLEHSLRRRTTQSTKHGEVDAWPGQRER ATAILLACRHLPLSFLSSPGQRAVLLAEAARTLEKVGDRRSCNDCQQMIVKLGGGTAIAA S
Number of residues	1141
Molecular Weight	123686.44
Theoretical pI	Not Available
GO Classification	Functions RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding E-box binding protein C-terminus binding Processes transcription, DNA-templated negative regulation of cholesterol efflux cellular response to starvation positive regulation of protein targeting to mitochondrion regulation of mitophagy small molecule metabolic process cellular response to laminar fluid shear stress regulation of cholesterol homeostasis positive regulation of transcription from RNA polymerase II promoter lipid metabolic process regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter negative regulation of transcription from RNA polymerase II promoter cholesterol metabolic process response to low-density lipoprotein particle positive regulation of cholesterol storage Components cytoplasm nucleus endoplasmic reticulum endoplasmic reticulum membrane ER to Golgi transport vesicle membrane cytosol nucleoplasm SREBP-SCAP-Insig complex Golgi membrane
General Function	Transcriptional repressor activity, rna polymerase ii core promoter proximal region sequence-specific binding
Specific Function	Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the cholesterol and to a lesser degree the fatty acid synthesis pathway (By similarity). Binds the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') found in the flanking region of the LDRL and HMG-CoA synthase genes.
Pfam Domain Function	HLH (PF00010 )
Transmembrane Regions	480-500 534-554
GenBank Protein ID	Not Available
UniProtKB ID	Q12772
UniProtKB Entry Name	SRBP2_HUMAN
Cellular Location	Endoplasmic reticulum membrane
Gene sequence	>lcl\|BSEQ0019819\|Sterol regulatory element-binding protein 2 (SREBF2) ATGGACGACAGCGGCGAGCTGGGTGGTCTGGAGACCATGGAGACCCTCACGGAGCTGGGC GACGAGCTGACCCTGGGAGACATCGACGAGATGCTGCAATTTGTCAGTAATCAAGTGGGA GAGTTCCCTGACTTGTTTTCAGAACAGCTGTGTAGCTCCTTTCCTGGCAGTGGTGGTAGT GGTAGCAGCAGCGGCAGCAGTGGCAGCAGCAGCAGCAGCAGCAATGGCAGGGGCAGCAGC AGCGGAGCTGTGGACCCTTCAGTGCAACGGTCATTCACCCAGGTCACATTACCTTCCTTC TCTCCCTCGGCGGCCTCCCCACAGGCTCCAACTCTGCAAGTCAAGGTTTCTCCCACCTCA GTTCCCACCACACCCAGGGCAACTCCTATTCTTCAGCCCCGCCCCCAGCCCCAGCCTCAA CCTCAAACTCAGCTGCAACAACAGACGGTAATGATCACGCCAACATTCAGCACCACTCCG CAGACGAGGATCATCCAGCAGCCTTTGATATACCAGAATGCAGCTACTAGCTTTCAAGTC CTTCAGCCTCAAGTCCAAAGCCTGGTGACATCCTCCCAGGTACAGCCGGTCACCATTCAG CAGCAGGTGCAGACAGTACAGGCCCAGCGGGTGCTGACACAAACGGCCAATGGCACGCTG CAGACCCTTGCCCCGGCTACGGTGCAGACAGTTGCTGCGCCACAGGTGCAGCAGGTCCCG GTCCTGGTCCAGCCTCAGATCATCAAGACAGATTCCCTTGTTTTGACCACACTGAAGACA GATGGCAGCCCTGTTATGGCTGCGGTCCAGAACCCGGCCCTCACCGCCCTCACCACCCCT ATCCAGACGGCTGCCCTTCAAGTACCAACCCTGGTGGGCAGCAGTGGGACCATTCTGACC ACAATGCCTGTAATGATGGGGCAAGAGAAAGTGCCCATTAAGCAGGTACCTGGGGGAGTC AAGCAGCTTGAGCCCCCCAAAGAAGGAGAAAGGCGGACAACCCATAATATCATTGAGAAA CGATATCGCTCCTCCATCAATGACAAAATCATCGAATTGAAAGACCTGGTCATGGGGACA GACGCCAAGATGCACAAGTCTGGCGTTCTGAGGAAGGCCATTGATTACATCAAATACTTG CAGCAGGTCAATCATAAACTGCGCCAGGAGAACATGGTGCTGAAGCTGGCAAATCAAAAG AACAAGCTTCTAAAGGGCATCGACCTAGGCAGTCTGGTGGACAATGAGGTGGACCTGAAG ATCGAGGACTTTAATCAGAATGTCCTTCTGATGTCCCCCCCAGCCTCTGACTCAGGGTCC CAGGCTGGCTTCTCTCCCTACTCCATTGACTCTGAGCCAGGAAGCCCTCTATTGGATGAT GCAAAGGTCAAAGATGAGCCAGACTCTCCTCCTGTGGCGCTGGGCATGGTAGACCGCTCA CGGATTCTTCTGTGTGTCCTCACCTTCCTGTGCCTCTCCTTTAACCCCCTGACTTCCCTG CTGCAGTGGGGAGGGGCCCACGACTCTGACCAGCACCCACACTCAGGCTCTGGCCGCAGT GTCCTGTCATTCGAGTCAGGTTCTGGGGGCTGGTTTGACTGGATGATGCCTACTCTTCTC TTATGGCTGGTAAATGGTGTGATTGTCCTGAGCGTCTTTGTGAAGCTGCTGGTTCATGGG GAGCCAGTGATCCGGCCACACTCGCGCTCCTCGGTCACCTTCTGGAGGCACCGGAAACAG GCAGATCTGGATCTCGCCAGAGGAGATTTTGCAGCTGCTGCCGGCAACCTACAAACCTGC CTGGCAGTTTTGGGCCGGGCACTGCCCACCTCCCGCCTGGACCTGGCCTGCAGCCTCTCC TGGAACGTGATCCGCTACAGCCTGCAGAAGCTACGCCTGGTGCGCTGGCTGCTCAAGAAA GTCTTCCAGTGCCGGCGGGCCACGCCAGCCACTGAGGCAGGCTTTGAAGACGAAGCTAAG ACCAGCGCCCGGGATGCGGCTCTGGCCTATCACCGGCTGCACCAGCTGCACATCACAGGG AAGCTTCCTGCAGGATCCGCCTGTTCCGATGTACACATGGCGTTGTGTGCCGTGAACCTG GCTGAATGTGCAGAGGAGAAGATCCCACCGAGCACACTGGTTGAGATCCATCTGACTGCT GCCATGGGGCTCAAGACCCGGTGTGGAGGCAAGCTGGGCTTCCTGGCCAGCTACTTCCTC AGCCGAGCCCAGAGCCTGTGTGGCCCCGAGCACAGTGCTGTTCCTGACTCCCTGCGCTGG CTCTGCCACCCCCTGGGCCAGAAGTTTTTCATGGAGCGGAGCTGGTCTGTGAAGTCAGCT GCCAAGGAGAGTCTATACTGTGCCCAGAGGAACCCAGCTGACCCCATTGCGCAGGTCCAC CAGGCCTTCTGCAAGAACCTGCTGGAGCGAGCTATAGAGTCCTTGGTGAAACCTCAGGCC AAGAAGAAGGCTGGAGACCAGGAAGAAGAGAGCTGTGAATTCTCCAGTGCTCTGGAGTAC TTGAAATTACTTCATTCTTTTGTGGACTCTGTGGGGGTTATGAGCCCCCCACTCTCCAGG AGCTCCGTGCTCAAGTCCGCCCTGGGTCCAGACATCATCTGTCGGTGGTGGACGTCTGCA ATCACTGTGGCCATCAGCTGGCTCCAGGGAGACGATGCAGCTGTGCGCTCTCATTTTACC AAAGTGGAACGCATCCCCAAGGCCCTGGAAGTGACAGAGAGCCCCCTGGTGAAGGCCATC TTCCATGCCTGCAGAGCCATGCATGCCTCACTCCCTGGGAAAGCAGATGGGCAGCAGAGT TCCTTCTGCCATTGCGAGAGGGCCAGTGGCCACCTATGGAGCAGCCTCAACGTCAGTGGG GCCACCTCTGACCCTGCCCTCAACCACGTGGTCCAGCTGCTCACCTGTGACCTGCTACTG TCGCTACGGACAGCGCTCTGGCAAAAACAGGCCAGTGCCAGCCAGGCTGTGGGGGAGACC TACCACGCGTCAGGCGCTGAACTGGCGGGCTTCCAACGGGACCTGGGCAGCCTGCGCAGG CTGGCACACAGCTTCCGCCCAGCATACCGCAAGGTGTTCCTGCATGAAGCCACCGTGCGC CTGATGGCAGGAGCCAGCCCCACCCGCACCCACCAGCTGCTGGAACACAGCCTGCGGCGG CGCACCACGCAGAGCACCAAGCACGGAGAGGTGGATGCCTGGCCCGGCCAGCGAGAGCGG GCCACCGCCATCCTGCTGGCCTGCCGCCACCTGCCCCTCTCCTTCCTCTCCTCCCCGGGC CAGCGGGCAGTGCTGCTGGCCGAAGCTGCCCGCACCCTGGAGAAGGTGGGCGACCGGCGC TCCTGCAACGACTGCCAGCAGATGATTGTTAAGCTGGGTGGTGGCACTGCCATTGCCGCC TCCTGA
GenBank Gene ID	Not Available
GeneCard ID	Not Available
GenAtlas ID	Not Available
HGNC ID	HGNC:11290
Chromosome Location	22
Locus	Not Available
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