Peroxiredoxin-1

NamePeroxiredoxin-1
Synonyms
  • 1.11.1.15
  • Natural killer cell-enhancing factor A
  • NKEF-A
  • PAG
  • PAGA
  • PAGB
  • Proliferation-associated gene protein
  • TDPX2
  • Thioredoxin peroxidase 2
  • Thioredoxin-dependent peroxide reductase 2
Gene NamePRDX1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0037288|Peroxiredoxin-1
MSSGNAKIGHPAPNFKATAVMPDGQFKDISLSDYKGKYVVFFFYPLDFTFVCPTEIIAFS
DRAEEFKKLNCQVIGASVDSHFCHLAWVNTPKKQGGLGPMNIPLVSDPKRTIAQDYGVLK
ADEGISFRGLFIIDDKGILRQITVNDLPVGRSVDETLRLVQAFQFTDKHGEVCPAGWKPG
SDTIKPDVQKSKEYFSKQK
Number of residues199
Molecular Weight22110.19
Theoretical pINot Available
GO Classification
Functions
  • poly(A) RNA binding
  • peroxidase activity
  • thioredoxin peroxidase activity
Processes
  • skeletal system development
  • natural killer cell mediated cytotoxicity
  • hydrogen peroxide catabolic process
  • retina homeostasis
  • regulation of stress-activated MAPK cascade
  • response to reactive oxygen species
  • erythrocyte homeostasis
  • removal of superoxide radicals
  • regulation of NF-kappaB import into nucleus
  • cell proliferation
  • gene expression
  • transcription initiation from RNA polymerase II promoter
Components
  • extracellular exosome
  • myelin sheath
  • melanosome
  • cytoplasm
  • mitochondrion
  • nucleus
  • extracellular space
  • cytosol
General FunctionThioredoxin peroxidase activity
Specific FunctionInvolved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation (By similarity).
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDQ06830
UniProtKB Entry NamePRDX1_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0013960|Peroxiredoxin-1 (PRDX1)
ATGTCTTCAGGAAATGCTAAAATTGGGCACCCTGCCCCCAACTTCAAAGCCACAGCTGTT
ATGCCAGATGGTCAGTTTAAAGATATCAGCCTGTCTGACTACAAAGGAAAATATGTTGTG
TTCTTCTTTTACCCTCTTGACTTCACCTTTGTGTGCCCCACGGAGATCATTGCTTTCAGT
GATAGGGCAGAAGAATTTAAGAAACTCAACTGCCAAGTGATTGGTGCTTCTGTGGATTCT
CACTTCTGTCATCTAGCATGGGTCAATACACCTAAGAAACAAGGAGGACTGGGACCCATG
AACATTCCTTTGGTATCAGACCCGAAGCGCACCATTGCTCAGGATTATGGGGTCTTAAAG
GCTGATGAAGGCATCTCGTTCAGGGGCCTTTTTATCATTGATGATAAGGGTATTCTTCGG
CAGATCACTGTAAATGACCTCCCTGTTGGCCGCTCTGTGGATGAGACTTTGAGACTAGTT
CAGGCCTTCCAGTTCACTGACAAACATGGGGAAGTGTGCCCAGCTGGCTGGAAACCTGGC
AGTGATACCATCAAGCCTGATGTCCAAAAGAGCAAAGAATATTTCTCCAAGCAGAAGTGA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:9352
Chromosome Location1
LocusNot Available
References
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