NameAldo-keto reductase family 1 member C1
Synonyms
  • 1.1.1.-
  • 20-alpha-HSD
  • 20-alpha-hydroxysteroid dehydrogenase
  • Chlordecone reductase homolog HAKRC
  • DD1/DD2
  • DDH
  • DDH1
  • Dihydrodiol dehydrogenase 1/2
  • HBAB
  • High-affinity hepatic bile acid-binding protein
  • Indanol dehydrogenase
  • Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
Gene NameAKR1C1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0016017|Aldo-keto reductase family 1 member C1
MDSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEATKLAIEAGFRHIDSAHLYNNEEQ
VGLAIRSKIADGSVKREDIFYTSKLWCNSHRPELVRPALERSLKNLQLDYVDLYLIHFPV
SVKPGEEVIPKDENGKILFDTVDLCATWEAVEKCKDAGLAKSIGVSNFNRRQLEMILNKP
GLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPV
LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN
RNVRYLTLDIFAGPPNYPFSDEY
Number of residues323
Molecular Weight36788.02
Theoretical pI7.99
GO Classification
Functions
  • carboxylic acid binding
  • 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity
  • ketosteroid monooxygenase activity
  • phenanthrene 9,10-monooxygenase activity
  • bile acid binding
  • trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
  • oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
  • aldo-keto reductase (NADP) activity
  • alditol
  • androsterone dehydrogenase (B-specific) activity
  • indanol dehydrogenase activity
Processes
  • bile acid and bile salt transport
  • digestion
  • retinal metabolic process
  • cellular response to jasmonic acid stimulus
  • oxidation-reduction process
  • daunorubicin metabolic process
  • phototransduction, visible light
  • doxorubicin metabolic process
  • cholesterol homeostasis
  • epithelial cell differentiation
  • xenobiotic metabolic process
  • progesterone metabolic process
  • retinoid metabolic process
  • protein homooligomerization
  • intestinal cholesterol absorption
  • response to organophosphorus
  • bile acid metabolic process
Components
  • cytosol
  • extracellular exosome
General FunctionTrans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
Specific FunctionConverts progesterone to its inactive form, 20-alpha-dihydroxyprogesterone (20-alpha-OHP). In the liver and intestine, may have a role in the transport of bile. May have a role in monitoring the intrahepatic bile acid concentration. Has a low bile-binding ability. May play a role in myelin formation.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID181549
UniProtKB IDQ04828
UniProtKB Entry NameAK1C1_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0016018|Aldo-keto reductase family 1 member C1 (AKR1C1)
ATGGATTCGAAATATCAGTGTGTGAAGCTGAATGATGGTCACTTCATGCCTGTCCTGGGA
TTTGGCACCTATGCGCCTGCAGAGGTTCCTAAAAGTAAAGCTTTAGAGGCCACCAAATTG
GCAATTGAAGCTGGCTTCCGCCATATTGATTCTGCTCATTTATACAATAATGAGGAGCAG
GTTGGACTGGCCATCCGAAGCAAGATTGCAGATGGCAGTGTGAAGAGAGAAGACATATTC
TACACTTCAAAGCTTTGGTGCAATTCCCATCGACCAGAGTTGGTCCGACCAGCCTTGGAA
AGGTCACTGAAAAATCTTCAATTGGATTATGTTGACCTCTACCTTATTCATTTTCCAGTG
TCTGTAAAGCCAGGTGAGGAAGTGATCCCAAAAGATGAAAATGGAAAAATACTATTTGAC
ACAGTGGATCTCTGTGCCACATGGGAGGCCGTGGAGAAGTGTAAAGATGCAGGATTGGCC
AAGTCCATCGGGGTGTCCAACTTCAACCGCAGGCAGCTGGAGATGATCCTCAACAAGCCA
GGGCTCAAGTACAAGCCTGTCTGCAACCAGGTGGAATGTCATCCTTACTTCAACCAGAGA
AAACTGCTGGATTTCTGCAAGTCAAAAGACATTGTTCTGGTTGCCTATAGTGCTCTGGGA
TCCCACCGAGAAGAACCATGGGTGGACCCGAACTCCCCGGTGCTCTTGGAGGACCCAGTC
CTTTGTGCCTTGGCAAAAAAGCACAAGCGAACCCCAGCCCTGATTGCCCTGCGCTACCAG
CTACAGCGTGGGGTTGTGGTCCTGGCCAAGAGCTACAATGAGCAGCGCATCAGACAGAAC
GTGCAGGTGTTTGAATTCCAGTTGACTTCAGAGGAGATGAAAGCCATAGATGGCCTAAAC
AGAAATGTGCGATATTTGACCCTTGATATTTTTGCTGGCCCCCCTAATTATCCATTTTCT
GATGAATATTAA
GenBank Gene IDM86609
GeneCard IDNot Available
GenAtlas IDAKR1C1
HGNC IDHGNC:384
Chromosome Location10
Locus10p15-p14
References
  1. Stolz A, Hammond L, Lou H, Takikawa H, Ronk M, Shively JE: cDNA cloning and expression of the human hepatic bile acid-binding protein. A member of the monomeric reductase gene family. J Biol Chem. 1993 May 15;268(14):10448-57. 8486699
  2. Lou H, Hammond L, Sharma V, Sparkes RS, Lusis AJ, Stolz A: Genomic organization and chromosomal localization of a novel human hepatic dihydrodiol dehydrogenase with high affinity bile acid binding. J Biol Chem. 1994 Mar 18;269(11):8416-22. 8132567
  3. Ciaccio PJ, Jaiswal AK, Tew KD: Regulation of human dihydrodiol dehydrogenase by Michael acceptor xenobiotics. J Biol Chem. 1994 Jun 3;269(22):15558-62. 7515059
  4. Khanna M, Qin KN, Cheng KC: Distribution of 3 alpha-hydroxysteroid dehydrogenase in rat brain and molecular cloning of multiple cDNAs encoding structurally related proteins in humans. J Steroid Biochem Mol Biol. 1995 Jun;53(1-6):41-6. 7626489
  5. Nishizawa M, Nakajima T, Yasuda K, Kanzaki H, Sasaguri Y, Watanabe K, Ito S: Close kinship of human 20alpha-hydroxysteroid dehydrogenase gene with three aldo-keto reductase genes. Genes Cells. 2000 Feb;5(2):111-25. 10672042
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  9. Qin KN, New MI, Cheng KC: Molecular cloning of multiple cDNAs encoding human enzymes structurally related to 3 alpha-hydroxysteroid dehydrogenase. J Steroid Biochem Mol Biol. 1993 Dec;46(6):673-9. 8274401
  10. Hara A, Matsuura K, Tamada Y, Sato K, Miyabe Y, Deyashiki Y, Ishida N: Relationship of human liver dihydrodiol dehydrogenases to hepatic bile-acid-binding protein and an oxidoreductase of human colon cells. Biochem J. 1996 Jan 15;313 ( Pt 2):373-6. 8573067
  11. Deyashiki Y, Ogasawara A, Nakayama T, Nakanishi M, Miyabe Y, Sato K, Hara A: Molecular cloning of two human liver 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase isoenzymes that are identical with chlordecone reductase and bile-acid binder. Biochem J. 1994 Apr 15;299 ( Pt 2):545-52. 8172617
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