Urokinase plasminogen activator surface receptor

NameUrokinase plasminogen activator surface receptor
Synonyms
  • MO3
  • Monocyte activation antigen Mo3
  • U-PAR
  • UPAR
Gene NamePLAUR
OrganismHuman
Amino acid sequence
>lcl|BSEQ0001430|Urokinase plasminogen activator surface receptor
MGHPPLLPLLLLLHTCVPASWGLRCMQCKTNGDCRVEECALGQDLCRTTIVRLWEEGEEL
ELVEKSCTHSEKTNRTLSYRTGLKITSLTEVVCGLDLCNQGNSGRAVTYSRSRYLECISC
GSSDMSCERGRHQSLQCRSPEEQCLDVVTHWIQEGEEGRPKDDRHLRGCGYLPGCPGSNG
FHNNDTFHFLKCCNTTKCNEGPILELENLPQNGRQCYSCKGNSTHGCSSEETFLIDCRGP
MNQCLVATGTHEPKNQSYMVRGCATASMCQHAHLGDAFSMNHIDVSCCTKSGCNHPDLDV
QYRSGAAPQPGPAHLSLTITLLMTARLWGGTLLWT
Number of residues335
Molecular Weight36977.62
Theoretical pI6.64
GO Classification
Functions
  • receptor binding
  • protein domain specific binding
  • enzyme binding
  • urokinase plasminogen activator receptor activity
  • receptor activity
Processes
  • fibrinolysis
  • signal transduction
  • movement of cell or subcellular component
  • blood coagulation
  • negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
  • negative regulation of intrinsic apoptotic signaling pathway
  • positive regulation of DNA binding
  • positive regulation of epidermal growth factor receptor signaling pathway
  • chemotaxis
  • positive regulation of release of cytochrome c from mitochondria
  • positive regulation of protein phosphorylation
  • regulation of proteolysis
  • cellular protein metabolic process
  • attachment of GPI anchor to protein
  • negative regulation of apoptotic process
  • C-terminal protein lipidation
  • post-translational protein modification
  • urokinase plasminogen activator signaling pathway
Components
  • focal adhesion
  • plasma membrane
  • endoplasmic reticulum membrane
  • integral component of membrane
  • anchored component of membrane
  • extracellular exosome
  • extrinsic component of membrane
  • invadopodium membrane
  • integral component of plasma membrane
  • endoplasmic reticulum lumen
General FunctionUrokinase plasminogen activator receptor activity
Specific FunctionActs as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID37605
UniProtKB IDQ03405
UniProtKB Entry NameUPAR_HUMAN
Cellular LocationCell membrane
Gene sequence
>lcl|BSEQ0016188|Urokinase plasminogen activator surface receptor (PLAUR)
ATGGGTCACCCGCCGCTGCTGCCGCTGCTGCTGCTGCTCCACACCTGCGTCCCAGCCTCT
TGGGGCCTGCGGTGCATGCAGTGTAAGACCAACGGGGATTGCCGTGTGGAAGAGTGCGCC
CTGGGACAGGACCTCTGCAGGACCACGATCGTGCGCTTGTGGGAAGAAGGAGAAGAGCTG
GAGCTGGTGGAGAAAAGCTGTACCCACTCAGAGAAGACCAACAGGACCCTGAGCTATCGG
ACTGGCTTGAAGATCACCAGCCTTACCGAGGTTGTGTGTGGGTTAGACTTGTGCAACCAG
GGCAACTCTGGCCGGGCTGTCACCTATTCCCGAAGCCGTTACCTCGAATGCATTTCCTGT
GGCTCATCAGACATGAGCTGTGAGAGGGGCCGGCACCAGAGCCTGCAGTGCCGCAGCCCT
GAAGAACAGTGCCTGGATGTGGTGACCCACTGGATCCAGGAAGGTGAAGAAGGGCGTCCA
AAGGATGACCGCCACCTCCGTGGCTGTGGCTACCTTCCCGGCTGCCCGGGCTCCAATGGT
TTCCACAACAACGACACCTTCCACTTCCTGAAATGCTGCAACACCACCAAATGCAACGAG
GGCCCAATCCTGGAGCTTGAAAATCTGCCGCAGAATGGCCGCCAGTGTTACAGCTGCAAG
GGGAACAGCACCCATGGATGCTCCTCTGAAGAGACTTTCCTCATTGACTGCCGAGGCCCC
ATGAATCAATGTCTGGTAGCCACCGGCACTCACGAACGCTCACTCTGGGGAAGCTGGTTG
CCATGTAAAAGTACTACTGCCCTGAGACCACCATGCTGTGAGGAAGCCCAAGCTACTCAT
GTATAA
GenBank Gene IDX51675
GeneCard IDNot Available
GenAtlas IDPLAUR
HGNC IDHGNC:9053
Chromosome Location19
Locus19q13
References
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