Peroxisome proliferator-activated receptor delta

NamePeroxisome proliferator-activated receptor delta
Synonyms
  • NR1C2
  • NUC1
  • NUCI
  • Nuclear hormone receptor 1
  • Nuclear receptor subfamily 1 group C member 2
  • Peroxisome proliferator-activated receptor beta
  • PPAR-beta
  • PPAR-delta
  • PPARB
Gene NamePPARD
OrganismHuman
Amino acid sequence
>lcl|BSEQ0002005|Peroxisome proliferator-activated receptor delta
MEQPQEEAPEVREEEEKEEVAEAEGAPELNGGPQHALPSSSYTDLSRSSSPPSLLDQLQM
GCDGASCGSLNMECRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLEYEKCERSCKIQKK
NRNKCQYCRFQKCLALGMSHNAIRFGRMPEAEKRKLVAGLTANEGSQYNPQVADLKAFSK
HIYNAYLKNFNMTKKKARSILTGKASHTAPFVIHDIETLWQAEKGLVWKQLVNGLPPYKE
ISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLNDQVTLLKYGVHEAIFAMLASIVNK
DGLLVANGSGFVTREFLRSLRKPFSDIIEPKFEFAVKFNALELDDSDLALFIAAIILCGD
RPGLMNVPRVEAIQDTILRALEFHLQANHPDAQYLFPKLLQKMADLRQLVTEHAQMMQRI
KKTETETSLHPLLQEIYKDMY
Number of residues441
Molecular Weight49902.99
Theoretical pI7.65
GO Classification
Functions
  • zinc ion binding
  • steroid hormone receptor activity
  • DNA binding
  • lipid binding
  • linoleic acid binding
  • sequence-specific DNA binding
  • transcription factor activity, sequence-specific DNA binding
  • RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
  • drug binding
Processes
  • glucose transport
  • wound healing
  • lipid metabolic process
  • negative regulation of epithelial cell proliferation
  • positive regulation of phosphatidylinositol 3-kinase signaling
  • adipose tissue development
  • negative regulation of transcription from RNA polymerase II promoter
  • fatty acid catabolic process
  • cholesterol metabolic process
  • keratinocyte migration
  • positive regulation of fat cell differentiation
  • cell-substrate adhesion
  • axon ensheathment
  • cellular response to hypoxia
  • cell proliferation
  • apoptotic signaling pathway
  • keratinocyte proliferation
  • fatty acid beta-oxidation
  • negative regulation of myoblast differentiation
  • intracellular receptor signaling pathway
  • gene expression
  • positive regulation of myoblast proliferation
  • embryo implantation
  • transcription initiation from RNA polymerase II promoter
  • positive regulation of skeletal muscle tissue regeneration
  • regulation of transcription from RNA polymerase II promoter
  • glucose metabolic process
  • regulation of satellite cell proliferation
  • negative regulation of transcription, DNA-templated
  • cell differentiation
  • fatty acid transport
  • positive regulation of transcription, DNA-templated
  • generation of precursor metabolites and energy
  • decidualization
  • apoptotic process
Components
  • nucleus
  • nucleoplasm
General FunctionZinc ion binding
Specific FunctionLigand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID190230
UniProtKB IDQ03181
UniProtKB Entry NamePPARD_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0019047|Peroxisome proliferator-activated receptor delta (PPARD)
ATGGAGCAGCCACAGGAGGAAGCCCCTGAGGTCCGGGAAGAGGAGGAGAAAGAGGAAGTG
GCAGAGGCAGAAGGAGCCCCAGAGCTCAATGGGGGACCACAGCATGCACTTCCTTCCAGC
AGCTACACAGACCTCTCCCGGAGCTCCTCGCCACCCTCACTGCTGGACCAACTGCAGATG
GGCTGTGACGGGGCCTCATGCGGCAGCCTCAACATGGAGTGCCGGGTGTGCGGGGACAAG
GCATCGGGCTTCCACTACGGTGTTCATGCATGTGAGGGGTGCAAGGGCTTCTTCCGTCGT
ACGATCCGCATGAAGCTGGAGTACGAGAAGTGTGAGCGCAGCTGCAAGATTCAGAAGAAG
AACCGCAACAAGTGCCAGTACTGCCGCTTCCAGAAGTGCCTGGCACTGGGCATGTCACAC
AACGCTATCCGTTTTGGTCGGATGCCGGAGGCTGAGAAGAGGAAGCTGGTGGCAGGGCTG
ACTGCAAACGAGGGGAGCCAGTACAACCCACAGGTGGCCGACCTGAAGGCCTTCTCCAAG
CACATCTACAATGCCTACCTGAAAAACTTCAACATGACCAAAAAGAAGGCCCGCAGCATC
CTCACCGGCAAAGCCAGCCACACGGCGCCCTTTGTGATCCACGACATCGAGACATTGTGG
CAGGCAGAGAAGGGGCTGGTGTGGAAGCAGTTGGTGAATGGCCTGCCTCCCTACAAGGAG
ATCAGCGTGCACGTCTTCTACCGCTGCCAGTGCACCACAGTGGAGACCGTGCGGGAGCTC
ACTGAGTTCGCCAAGAGCATCCCCAGCTTCAGCAGCCTCTTCCTCAACGACCAGGTTACC
CTTCTCAAGTATGGCGTGCACGAGGCCATCTTCGCCATGCTGGCCTCTATCGTCAACAAG
GACGGGCTGCTGGTAGCCAACGGCAGTGGCTTTGTCACCCGTGAGTTCCTGCGCAGCCTC
CGCAAACCCTTCAGTGATATCATTGAGCCTAAGTTTGAATTTGCTGTCAAGTTCAACGCC
CTGGAACTTGATGACAGTGACCTGGCCCTATTCATTGCGGCCATCATTCTGTGTGGAGAC
CGGCCAGGCCTCATGAACGTTCCACGGGTGGAGGCTATCCAGGACACCATCCTGCGTGCC
CTCGAATTCCACCTGCAGGCCAACCACCCTGATGCCCAGTACCTCTTCCCCAAGCTGCTG
CAGAAGATGGCTGACCTGCGGCAACTGGTCACCGAGCACGCCCAGATGATGCAGCGGATC
AAGAAGACCGAAACCGAGACCTCGCTGCACCCTCTGCTCCAGGAGATCTACAAGGACATG
TACTAA
GenBank Gene IDL07592
GeneCard IDNot Available
GenAtlas IDPPARD
HGNC IDHGNC:9235
Chromosome Location6
Locus6p21.2-p21.1
References
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