NameGuanine nucleotide-binding protein subunit alpha-12
Synonyms
  • G alpha-12
Gene NameGNA12
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009113|Guanine nucleotide-binding protein subunit alpha-12
MSGVVRTLSRCLLPAEAGGARERRAGSGARDAEREARRRSRDIDALLARERRAVRRLVKI
LLLGAGESGKSTFLKQMRIIHGREFDQKALLEFRDTIFDNILKGSRVLVDARDKLGIPWQ
YSENEKHGMFLMAFENKAGLPVEPATFQLYVPALSALWRDSGIREAFSRRSEFQLGESVK
YFLDNLDRIGQLNYFPSKQDILLARKATKGIVEHDFVIKKIPFKMVDVGGQRSQRQKWFQ
CFDGITSILFMVSSSEYDQVLMEDRRTNRLVESMNIFETIVNNKLFFNVSIILFLNKMDL
LVEKVKTVSIKKHFPDFRGDPHRLEDVQRYLVQCFDRKRRNRSKPLFHHFTTAIDTENVR
FVFHAVKDTILQENLKDIMLQ
Number of residues381
Molecular Weight44278.81
Theoretical pINot Available
GO Classification
Functions
  • signal transducer activity
  • GTP binding
  • GTPase activity
  • G-protein beta/gamma-subunit complex binding
  • D5 dopamine receptor binding
  • metal ion binding
Processes
  • regulation of cell shape
  • platelet activation
  • in utero embryonic development
  • cell differentiation
  • G-protein coupled receptor signaling pathway
  • Rho protein signal transduction
  • regulation of TOR signaling
  • adenylate cyclase-modulating G-protein coupled receptor signaling pathway
  • regulation of proteasomal ubiquitin-dependent protein catabolic process
  • embryonic digit morphogenesis
  • blood coagulation
  • response to drug
  • regulation of fibroblast migration
Components
  • brush border membrane
  • focal adhesion
  • plasma membrane
  • heterotrimeric G-protein complex
General FunctionSignal transducer activity
Specific FunctionGuanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. May play a role in the control of cell migration through the TOR signaling cascade.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDQ03113
UniProtKB Entry NameGNA12_HUMAN
Cellular LocationMembrane
Gene sequenceNot Available
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:4380
Chromosome LocationNot Available
LocusNot Available
References
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