NameGlutathione S-transferase Mu 4
Synonyms
  • 2.5.1.18
  • GST class-mu 4
  • GST-Mu2
  • GSTM4-4
Gene NameGSTM4
OrganismHuman
Amino acid sequence
>lcl|BSEQ0037082|Glutathione S-transferase Mu 4
MSMTLGYWDIRGLAHAIRLLLEYTDSSYEEKKYTMGDAPDYDRSQWLNEKFKLGLDFPNL
PYLIDGAHKITQSNAILCYIARKHNLCGETEEEKIRVDILENQAMDVSNQLARVCYSPDF
EKLKPEYLEELPTMMQHFSQFLGKRPWFVGDKITFVDFLAYDVLDLHRIFEPNCLDAFPN
LKDFISRFEGLEKISAYMKSSRFLPKPLYTRVAVWGNK
Number of residues218
Molecular Weight25561.095
Theoretical pI5.69
GO Classification
Functions
  • glutathione binding
  • glutathione transferase activity
  • enzyme binding
  • protein homodimerization activity
Processes
  • xenobiotic metabolic process
  • glutathione metabolic process
  • glutathione derivative biosynthetic process
  • nitrobenzene metabolic process
  • xenobiotic catabolic process
  • small molecule metabolic process
Components
  • cytoplasm
  • cytosol
General FunctionProtein homodimerization activity
Specific FunctionConjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Active on 1-chloro-2,4-dinitrobenzene.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID306819
UniProtKB IDQ03013
UniProtKB Entry NameGSTM4_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0019013|Glutathione S-transferase Mu 4 (GSTM4)
ATGTCCATGACACTGGGGTACTGGGACATCCGCGGGCTGGCCCACGCCATCCGCCTGCTC
CTGGAATACACAGACTCAAGCTACGAGGAAAAGAAGTATACGATGGGGGACGCTCCTGAC
TATGACAGAAGCCAGTGGCTGAATGAAAAATTCAAGCTGGGCCTGGACTTTCCCAATCTG
CCCTACTTGATTGATGGGGCTCACAAGATCACCCAGAGCAACGCCATCCTGTGCTACATT
GCCCGCAAGCACAACCTGTGTGGGGAGACAGAAGAGGAGAAGATTCGTGTGGACATTTTG
GAGAACCAGGCTATGGACGTCTCCAATCAGCTGGCCAGAGTCTGCTACAGCCCTGACTTT
GAGAAACTGAAGCCAGAATACTTGGAGGAACTTCCTACAATGATGCAGCACTTCTCACAG
TTCCTGGGGAAGAGGCCATGGTTTGTTGGAGACAAGATCACCTTTGTAGATTTCCTCGCC
TATGATGTCCTTGACCTCCACCGTATATTTGAGCCCAACTGCTTGGACGCCTTTCCAAAT
CTGAAGGACTTCATCTCCCGCTTTGAGGGCTTGGAGAAGATCTCTGCCTACATGAAGTCC
AGCCGCTTCCTCCCAAAACCTCTGTACACAAGGGTGGCTGTCTGGGGCAACAAGTAA
GenBank Gene IDM96234
GeneCard IDNot Available
GenAtlas IDGSTM4
HGNC IDHGNC:4636
Chromosome Location1
Locus1p13.3
References
  1. Comstock KE, Johnson KJ, Rifenbery D, Henner WD: Isolation and analysis of the gene and cDNA for a human Mu class glutathione S-transferase, GSTM4. J Biol Chem. 1993 Aug 15;268(23):16958-65. 8349586
  2. Zhong S, Spurr NK, Hayes JD, Wolf CR: Deduced amino acid sequence, gene structure and chromosomal location of a novel human class Mu glutathione S-transferase, GSTM4. Biochem J. 1993 Apr 1;291 ( Pt 1):41-50. 8471052
  3. Ross VL, Board PG: Molecular cloning and heterologous expression of an alternatively spliced human Mu class glutathione S-transferase transcript. Biochem J. 1993 Sep 1;294 ( Pt 2):373-80. 8373352
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