Melanocyte-stimulating hormone receptor

NameMelanocyte-stimulating hormone receptor
Synonyms
  • MC1-R
  • Melanocortin receptor 1
  • MSH-R
  • MSHR
Gene NameMC1R
OrganismHuman
Amino acid sequence
>lcl|BSEQ0011751|Melanocyte-stimulating hormone receptor
MAVQGSQRRLLGSLNSTPTAIPQLGLAANQTGARCLEVSISDGLFLSLGLVSLVENALVV
ATIAKNRNLHSPMYCFICCLALSDLLVSGSNVLETAVILLLEAGALVARAAVLQQLDNVI
DVITCSSMLSSLCFLGAIAVDRYISIFYALRYHSIVTLPRARRAVAAIWVASVVFSTLFI
AYYDHVAVLLCLVVFFLAMLVLMAVLYVHMLARACQHAQGIARLHKRQRPVHQGFGLKGA
VTLTILLGIFFLCWGPFFLHLTLIVLCPEHPTCGCIFKNFNLFLALIICNAIIDPLIYAF
HSQELRRTLKEVLTCSW
Number of residues317
Molecular Weight34705.04
Theoretical pI8.44
GO Classification
Functions
  • melanocyte-stimulating hormone receptor activity
  • melanocortin receptor activity
  • ubiquitin protein ligase binding
  • hormone binding
  • G-protein coupled peptide receptor activity
Processes
  • pigmentation
  • positive regulation of feeding behavior
  • positive regulation of protein kinase A signaling
  • positive regulation of transcription from RNA polymerase II promoter
  • UV protection
  • multicellular organismal development
  • UV-damage excision repair
  • intracellular signal transduction
  • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
  • sensory perception of pain
  • positive regulation of cAMP biosynthetic process
  • positive regulation of protein kinase C signaling
  • melanin biosynthetic process
  • positive regulation of protein kinase B signaling
  • negative regulation of tumor necrosis factor production
Components
  • plasma membrane
  • integral component of plasma membrane
  • intracellular
General FunctionUbiquitin protein ligase binding
Specific FunctionReceptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.
Pfam Domain Function
Transmembrane Regions38-63 73-93 119-140 164-183 192-211 241-266 280-300
GenBank Protein IDNot Available
UniProtKB IDQ01726
UniProtKB Entry NameMSHR_HUMAN
Cellular LocationCell membrane
Gene sequence
>lcl|BSEQ0011752|Melanocyte-stimulating hormone receptor (MC1R)
ATGGCTGTGCAGGGATCCCAGAGAAGACTTCTGGGCTCCCTCAACTCCACCCCCACAGCC
ATCCCCCAGCTGGGGCTGGCTGCCAACCAGACAGGAGCCCGGTGCCTGGAGGTGTCCATC
TCTGACGGGCTCTTCCTCAGCCTGGGGCTGGTGAGCTTGGTGGAGAACGCGCTGGTGGTG
GCCACCATCGCCAAGAACCGGAACCTGCACTCACCCATGTACTGCTTCATCTGCTGCCTG
GCCTTGTCGGACCTGCTGGTGAGCGGGAGCAACGTGCTGGAGACGGCCGTCATCCTCCTG
CTGGAGGCCGGTGCACTGGTGGCCCGGGCTGCGGTGCTGCAGCAGCTGGACAATGTCATT
GACGTGATCACCTGCAGCTCCATGCTGTCCAGCCTCTGCTTCCTGGGCGCCATCGCCGTG
GACCGCTACATCTCCATCTTCTACGCACTGCGCTACCACAGCATCGTGACCCTGCCGCGG
GCGCGGCGAGCCGTTGCGGCCATCTGGGTGGCCAGTGTCGTCTTCAGCACGCTCTTCATC
GCCTACTACGACCACGTGGCCGTCCTGCTGTGCCTCGTGGTCTTCTTCCTGGCTATGCTG
GTGCTCATGGCCGTGCTGTACGTCCACATGCTGGCCCGGGCCTGCCAGCACGCCCAGGGC
ATCGCCCGGCTCCACAAGAGGCAGCGCCCGGTCCACCAGGGCTTTGGCCTTAAAGGCGCT
GTCACCCTCACCATCCTGCTGGGCATTTTCTTCCTCTGCTGGGGCCCCTTCTTCCTGCAT
CTCACACTCATCGTCCTCTGCCCCGAGCACCCCACGTGCGGCTGCATCTTCAAGAACTTC
AACCTCTTTCTCGCCCTCATCATCTGCAATGCCATCATCGACCCCCTCATCTACGCCTTC
CACAGCCAGGAGCTCCGCAGGACGCTCAAGGAGGTGCTGACATGCTCCTGGTGA
GenBank Gene IDX65634
GeneCard IDNot Available
GenAtlas IDMC1R
HGNC IDHGNC:6929
Chromosome Location16
Locus16q24.3
References
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