Transcription factor E2F1

NameTranscription factor E2F1
Synonyms
  • E2F-1
  • PBR3
  • pRB-binding protein E2F-1
  • RBAP-1
  • RBBP-3
  • RBBP3
  • Retinoblastoma-associated protein 1
  • Retinoblastoma-binding protein 3
Gene NameE2F1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009214|Transcription factor E2F1
MALAGAPAGGPCAPALEALLGAGALRLLDSSQIVIISAAQDASAPPAPTGPAAPAAGPCD
PDLLLFATPQAPRPTPSAPRPALGRPPVKRRLDLETDHQYLAESSGPARGRGRHPGKGVK
SPGEKSRYETSLNLTTKRFLELLSHSADGVVDLNWAAEVLKVQKRRIYDITNVLEGIQLI
AKKSKNHIQWLGSHTTVGVGGRLEGLTQDLRQLQESEQQLDHLMNICTTQLRLLSEDTDS
QRLAYVTCQDLRSIADPAEQMVMVIKAPPETQLQAVDSSENFQISLKSKQGPIDVFLCPE
ETVGGISPGKTPSQEVTSEEENRATDSATIVSPPPSSPPSSLTTDPSQSLLSLEQEPLLS
RMGSLRAPVDEDRLSPLVAADSLLEHVREDFSGLLPEEFISLSPPHEALDYHFGLEEGEG
IRDLFDCDFGDLTPLDF
Number of residues437
Molecular Weight46919.28
Theoretical pINot Available
GO Classification
Functions
  • DNA binding
  • transcription factor binding
  • transcription factor activity, sequence-specific DNA binding
  • sequence-specific DNA binding
  • core promoter binding
Processes
  • positive regulation of gene expression
  • negative regulation of DNA binding
  • G1/S transition of mitotic cell cycle
  • negative regulation of fat cell differentiation
  • forebrain development
  • anoikis
  • intrinsic apoptotic signaling pathway
  • programmed cell death
  • intrinsic apoptotic signaling pathway by p53 class mediator
  • cellular response to xenobiotic stimulus
  • negative regulation of fat cell proliferation
  • Notch signaling pathway
  • positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
  • intrinsic apoptotic signaling pathway in response to DNA damage
  • lens fiber cell apoptotic process
  • spermatogenesis
  • regulation of transcription, DNA-templated
  • mRNA stabilization
  • negative regulation of transcription, DNA-templated
  • positive regulation of transcription, DNA-templated
  • negative regulation of transcription involved in G1/S transition of mitotic cell cycle
  • cellular response to nerve growth factor stimulus
  • apoptotic process
  • cellular response to fatty acid
  • positive regulation of transcription from RNA polymerase II promoter
  • positive regulation of fibroblast proliferation
  • negative regulation of transcription from RNA polymerase II promoter
  • mitotic cell cycle
  • DNA damage checkpoint
  • cellular response to hypoxia
  • transcription, DNA-templated
  • regulation of G1/S transition of mitotic cell cycle
Components
  • cytoplasm
  • nucleus
  • nuclear chromatin
  • nucleoplasm
  • Rb-E2F complex
General FunctionTranscription factor binding
Specific FunctionTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis. Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA binding to its target gene promoters (PubMed:20176812).
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDQ01094
UniProtKB Entry NameE2F1_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0020866|Transcription factor E2F1 (E2F1)
ATGGCCTTGGCCGGGGCCCCTGCGGGCGGCCCATGCGCGCCGGCGCTGGAGGCCCTGCTC
GGGGCCGGCGCGCTGCGGCTGCTCGACTCCTCGCAGATCGTCATCATCTCCGCCGCGCAG
GACGCCAGCGCCCCGCCGGCTCCCACCGGCCCCGCGGCGCCCGCCGCCGGCCCCTGCGAC
CCTGACCTGCTGCTCTTCGCCACACCGCAGGCGCCCCGGCCCACACCCAGTGCGCCGCGG
CCCGCGCTCGGCCGCCCGCCGGTGAAGCGGAGGCTGGACCTGGAAACTGACCATCAGTAC
CTGGCCGAGAGCAGTGGGCCAGCTCGGGGCAGAGGCCGCCATCCAGGAAAAGGTGTGAAA
TCCCCGGGGGAGAAGTCACGCTATGAGACCTCACTGAATCTGACCACCAAGCGCTTCCTG
GAGCTGCTGAGCCACTCGGCTGACGGTGTCGTCGACCTGAACTGGGCTGCCGAGGTGCTG
AAGGTGCAGAAGCGGCGCATCTATGACATCACCAACGTCCTTGAGGGCATCCAGCTCATT
GCCAAGAAGTCCAAGAACCACATCCAGTGGCTGGGCAGCCACACCACAGTGGGCGTCGGC
GGACGGCTTGAGGGGTTGACCCAGGACCTCCGACAGCTGCAGGAGAGCGAGCAGCAGCTG
GACCACCTGATGAATATCTGTACTACGCAGCTGCGCCTGCTCTCCGAGGACACTGACAGC
CAGCGCCTGGCCTACGTGACGTGTCAGGACCTTCGTAGCATTGCAGACCCTGCAGAGCAG
ATGGTTATGGTGATCAAAGCCCCTCCTGAGACCCAGCTCCAAGCCGTGGACTCTTCGGAG
AACTTTCAGATCTCCCTTAAGAGCAAACAAGGCCCGATCGATGTTTTCCTGTGCCCTGAG
GAGACCGTAGGTGGGATCAGCCCTGGGAAGACCCCATCCCAGGAGGTCACTTCTGAGGAG
GAGAACAGGGCCACTGACTCTGCCACCATAGTGTCACCACCACCATCATCTCCCCCCTCA
TCCCTCACCACAGATCCCAGCCAGTCTCTACTCAGCCTGGAGCAAGAACCGCTGTTGTCC
CGGATGGGCAGCCTGCGGGCTCCCGTGGACGAGGACCGCCTGTCCCCGCTGGTGGCGGCC
GACTCGCTCCTGGAGCATGTGCGGGAGGACTTCTCCGGCCTCCTCCCTGAGGAGTTCATC
AGCCTTTCCCCACCCCACGAGGCCCTCGACTACCACTTCGGCCTCGAGGAGGGCGAGGGC
ATCAGAGACCTCTTCGACTGTGACTTTGGGGACCTCACCCCCCTGGATTTCTGA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:3113
Chromosome Location20
LocusNot Available
References
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