Very low-density lipoprotein receptor

NameVery low-density lipoprotein receptor
Synonyms
  • VLDL receptor
Gene NameVLDLR
OrganismHuman
Amino acid sequence
>lcl|BSEQ0007684|Very low-density lipoprotein receptor
MGTSALWALWLLLALCWAPRESGATGTGRKAKCEPSQFQCTNGRCITLLWKCDGDEDCVD
GSDEKNCVKKTCAESDFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISC
GAHSTQCIPVSWRCDGENDCDSGEDEENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCS
DGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCP
ASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGI
RDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKECHINEC
LVNNGGCSHICKDLVIGYECDCAAGFELIDRKTCGDIDECQNPGICSQICINLKGGYKCE
CSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDADIAA
QKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVA
TLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQ
WPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWI
DGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYLCL
PAPQINDHSPKYTCSCPSGYNVEENGRDCQSTATTVTYSETKDTNTTEISATSGLVPGGI
NVTTAVSEVSVPPKGTSAAWAILPLLLLVMAAVGGYLMWRNWQHKNMKSMNFDNPVYLKT
TEEDLSIDIGRHSASVGHTYPAISVVSTDDDLA
Number of residues873
Molecular Weight96097.45
Theoretical pI4.39
GO Classification
Functions
  • very-low-density lipoprotein particle binding
  • reelin receptor activity
  • calcium-dependent protein binding
  • glycoprotein binding
  • glycoprotein transporter activity
  • apolipoprotein binding
  • calcium ion binding
  • low-density lipoprotein receptor activity
  • very-low-density lipoprotein particle receptor activity
Processes
  • cholesterol metabolic process
  • response to drug
  • ventral spinal cord development
  • cellular response to hypoxia
  • lipid transport
  • memory
  • very-low-density lipoprotein particle clearance
  • cellular response to glucose starvation
  • positive regulation of dendrite development
  • response to nutrient
  • reelin-mediated signaling pathway
  • receptor-mediated endocytosis
  • positive regulation of protein kinase activity
  • heart development
  • cerebral cortex development
  • nervous system development
  • cellular response to interleukin-1
  • dendrite morphogenesis
  • negative regulation of transcription from RNA polymerase II promoter
  • glycoprotein transport
  • cellular response to insulin stimulus
  • signal transduction
  • cellular response to lipopolysaccharide
Components
  • plasma membrane
  • receptor complex
  • cell surface
  • apical part of cell
  • coated pit
  • integral component of membrane
  • perinuclear region of cytoplasm
  • membrane
  • very-low-density lipoprotein particle
  • nucleus
General FunctionVery-low-density lipoprotein particle receptor activity
Specific FunctionBinds VLDL and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Binding to Reelin induces tyrosine phosphorylation of Dab1 and modulation of Tau phosphorylation (By similarity).
Pfam Domain Function
Transmembrane Regions798-819
GenBank Protein ID409426
UniProtKB IDP98155
UniProtKB Entry NameVLDLR_HUMAN
Cellular LocationMembrane
Gene sequence
>lcl|BSEQ0021379|Very low-density lipoprotein receptor (VLDLR)
ATGGGCACGTCCGCGCTCTGGGCGCTCTGGCTGCTGCTCGCGCTGTGCTGGGCGCCCCGG
GAGAGCGGCGCCACCGGAACCGGGAGAAAAGCCAAATGTGAACCCTCCCAATTCCAGTGC
ACAAATGGTCGCTGTATTACGCTGTTGTGGAAATGTGATGGGGATGAAGACTGTGTTGAC
GGCAGTGATGAAAAGAACTGTGTAAAGAAGACGTGTGCTGAATCTGACTTCGTGTGCAAC
AATGGCCAGTGTGTTCCCAGCCGATGGAAGTGTGATGGAGATCCTGACTGCGAAGATGGT
TCAGATGAAAGCCCAGAACAGTGCCATATGAGAACATGCCGCATACATGAAATCAGCTGT
GGCGCCCATTCTACTCAGTGTATCCCAGTGTCCTGGAGATGTGATGGTGAAAATGATTGT
GACAGTGGAGAAGATGAAGAAAACTGTGGCAATATAACATGTAGTCCCGACGAGTTCACC
TGCTCCAGTGGCCGCTGCATCTCCAGGAACTTTGTATGCAATGGCCAGGATGACTGCAGC
GATGGCAGTGATGAGCTGGACTGTGCCCCGCCAACCTGTGGCGCCCATGAGTTCCAGTGC
AGCACCTCCTCCTGCATCCCCATCAGCTGGGTATGCGACGATGATGCAGACTGCTCCGAC
CAATCTGATGAGTCCCTGGAGCAGTGTGGCCGTCAGCCAGTCATACACACCAAGTGTCCA
GCCAGCGAAATCCAGTGCGGCTCTGGCGAGTGCATCCATAAGAAGTGGCGATGTGATGGG
GACCCTGACTGCAAGGATGGCAGTGATGAGGTCAACTGTCCCTCTCGAACTTGCCGACCT
GACCAATTTGAATGTGAGGATGGCAGCTGCATCCATGGCAGCAGGCAGTGTAATGGTATC
CGAGACTGTGTCGATGGTTCCGATGAAGTCAACTGCAAAAATGTCAATCAGTGCTTGGGC
CCTGGAAAATTCAAGTGCAGAAGTGGAGAATGCATAGATATCAGCAAAGTATGTAACCAG
GAGCAGGACTGCAGGGACTGGAGTGATGAGCCCCTGAAAGAGTGTCATATAAACGAATGC
TTGGTAAATAATGGTGGATGTTCTCATATCTGCAAAGACCTAGTTATAGGCTACGAGTGT
GACTGTGCAGCTGGGTTTGAACTGATAGATAGGAAAACCTGTGGAGATATTGATGAATGC
CAAAATCCAGGAATCTGCAGTCAAATTTGTATCAACTTAAAAGGCGGTTACAAGTGTGAA
TGTAGTCGTGGCTATCAAATGGATCTTGCTACTGGCGTGTGCAAGGCAGTAGGCAAAGAG
CCAAGTCTGATCTTCACTAATCGAAGAGACATCAGGAAGATTGGCTTAGAGAGGAAAGAA
TATATCCAACTAGTTGAACAGCTAAGAAACACTGTGGCTCTCGATGCTGACATTGCTGCC
CAGAAACTATTCTGGGCCGATCTAAGCCAAAAGGCTATCTTCAGTGCCTCAATTGATGAC
AAGGTTGGTAGACATGTTAAAATGATCGACAATGTCTATAATCCTGCAGCCATTGCTGTT
GATTGGGTGTACAAGACCATCTACTGGACTGATGCGGCTTCTAAGACTATTTCAGTAGCT
ACCCTAGATGGAACCAAGAGGAAGTTCCTGTTTAACTCTGACTTGCGAGAGCCTGCCTCC
ATAGCTGTGGACCCACTGTCTGGCTTTGTTTACTGGTCAGACTGGGGTGAACCAGCTAAA
ATAGAAAAAGCAGGAATGAATGGATTCGATAGACGTCCACTGGTGACAGCGGATATCCAG
TGGCCTAACGGAATTACACTTGACCTTATAAAAAGTCGCCTCTATTGGCTTGATTCTAAG
TTGCACATGTTATCCAGCGTGGACTTGAATGGCCAAGATCGTAGGATAGTACTAAAGTCT
CTGGAGTTCCTAGCTCATCCTCTTGCACTAACAATATTTGAGGATCGTGTCTACTGGATA
GATGGGGAAAATGAAGCAGTCTATGGTGCCAATAAATTCACTGGATCAGAGCTAGCCACT
CTAGTCAACAACCTGAATGATGCCCAAGACATCATTGTCTATCATGAACTTGTACAGCCA
TCAGGTAAAAATTGGTGTGAAGAAGACATGGAGAATGGAGGATGTGAATACCTATGCCTG
CCAGCACCACAGATTAATGATCACTCTCCAAAATATACCTGTTCCTGTCCCAGTGGGTAC
AATGTAGAGGAAAATGGCCGAGACTGTCAAAGGATCAATGTGACCACAGCAGTATCAGAG
GTCAGTGTTCCCCCAAAAGGGACTTCTGCCGCATGGGCCATTCTTCCTCTCTTGCTCTTA
GTGATGGCAGCAGTAGGTGGCTACTTGATGTGGCGGAATTGGCAACACAAGAACATGAAA
AGCATGAACTTTGACAATCCTGTGTACTTGAAAACCACTGAAGAGGACCTCTCCATAGAC
ATTGGTAGACACAGTGCTTCTGTTGGACACACGTACCCAGCAATATCAGTTGTAAGCACA
GATGATGATCTAGCTTGA
GenBank Gene IDL20470
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:12698
Chromosome Location9
Locus9p24
References
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  2. Webb JC, Patel DD, Jones MD, Knight BL, Soutar AK: Characterization and tissue-specific expression of the human 'very low density lipoprotein (VLDL) receptor' mRNA. Hum Mol Genet. 1994 Apr;3(4):531-7. 8069294
  3. Sakai J, Hoshino A, Takahashi S, Miura Y, Ishii H, Suzuki H, Kawarabayasi Y, Yamamoto T: Structure, chromosome location, and expression of the human very low density lipoprotein receptor gene. J Biol Chem. 1994 Jan 21;269(3):2173-82. 8294473
  4. Oka K, Tzung KW, Sullivan M, Lindsay E, Baldini A, Chan L: Human very-low-density lipoprotein receptor complementary DNA and deduced amino acid sequence and localization of its gene (VLDLR) to chromosome band 9p24 by fluorescence in situ hybridization. Genomics. 1994 Mar 15;20(2):298-300. 8020981
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