Histone H3.3

NameHistone H3.3
Synonyms
  • H3.3A
  • H3.3B
  • H3F3
Gene NameH3F3A
OrganismHuman
Amino acid sequence
>lcl|BSEQ0008753|Histone H3.3
MARTKQTARKSTGGKAPRKQLATKAARKSAPSTGGVKKPHRYRPGTVALREIRRYQKSTE
LLIRKLPFQRLVREIAQDFKTDLRFQSAAIGALQEASEAYLVGLFEDTNLCAIHAKRVTI
MPKDIQLARRIRGERA
Number of residues136
Molecular Weight15327.745
Theoretical pINot Available
GO Classification
Functions
  • RNA polymerase II core promoter sequence-specific DNA binding
  • nucleosomal DNA binding
  • histone binding
  • RNA polymerase II distal enhancer sequence-specific DNA binding
Processes
  • gene silencing by RNA
  • blood coagulation
  • small GTPase mediated signal transduction
  • gene expression
  • chromatin silencing at rDNA
  • cellular protein metabolic process
  • DNA replication-independent nucleosome assembly
  • positive regulation of cell growth
  • nucleosome assembly
  • brain development
  • response to hormone
  • DNA methylation on cytosine
  • negative regulation of gene expression, epigenetic
  • regulation of gene expression, epigenetic
Components
  • extracellular region
  • nuclear chromosome
  • nucleus
  • nuclear nucleosome
  • nucleosome
  • extracellular exosome
  • nucleoplasm
  • protein complex
General FunctionRna polymerase ii distal enhancer sequence-specific dna binding
Specific FunctionVariant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDP84243
UniProtKB Entry NameH33_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0013395|Histone H3.3 (H3F3A)
ATGGCTCGTACAAAGCAGACTGCCCGCAAATCGACCGGTGGTAAAGCACCCAGGAAGCAA
CTGGCTACAAAAGCCGCTCGCAAGAGTGCGCCCTCTACTGGAGGGGTGAAGAAACCTCAT
CGTTACAGGCCTGGTACTGTGGCGCTCCGTGAAATTAGACGTTATCAGAAGTCCACTGAA
CTTCTGATTCGCAAACTTCCCTTCCAGCGTCTGGTGCGAGAAATTGCTCAGGACTTTAAA
ACAGATCTGCGCTTCCAGAGCGCAGCTATCGGTGCTTTGCAGGAGGCAAGTGAGGCCTAT
CTGGTTGGCCTTTTTGAAGACACCAACCTGTGTGCTATCCATGCCAAACGTGTAACAATT
ATGCCAAAAGACATCCAGCTAGCACGCCGCATACGTGGAGAACGTGCTTAA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:4764
Chromosome Location17
LocusNot Available
References
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