T3DB: DNA-dependent protein kinase catalytic subunit

Name	DNA-dependent protein kinase catalytic subunit
Synonyms	2.7.11.1 DNA-PK catalytic subunit DNPK1 HYRC HYRC1 p460
Gene Name	PRKDC
Organism	Human
Amino acid sequence	>lcl\|BSEQ0004685\|DNA-dependent protein kinase catalytic subunit MAGSGAGVRCSLLRLQETLSAADRCGAALAGHQLIRGLGQECVLSSSPAVLALQTSLVFS RDFGLLVFVRKSLNSIEFRECREEILKFLCIFLEKMGQKIAPYSVEIKNTCTSVYTKDRA AKCKIPALDLLIKLLQTFRSSRLMDEFKIGELFSKFYGELALKKKIPDTVLEKVYELLGL LGEVHPSEMINNAENLFRAFLGELKTQMTSAVREPKLPVLAGCLKGLSSLLCNFTKSMEE DPQTSREIFNFVLKAIRPQIDLKRYAVPSAGLRLFALHASQFSTCLLDNYVSLFEVLLKW CAHTNVELKKAALSALESFLKQVSNMVAKNAEMHKNKLQYFMEQFYGIIRNVDSNNKELS IAIRGYGLFAGPCKVINAKDVDFMYVELIQRCKQMFLTQTDTGDDRVYQMPSFLQSVASV LLYLDTVPEVYTPVLEHLVVMQIDSFPQYSPKMQLVCCRAIVKVFLALAAKGPVLRNCIS TVVHQGLIRICSKPVVLPKGPESESEDHRASGEVRTGKWKVPTYKDYVDLFRHLLSSDQM MDSILADEAFFSVNSSSESLNHLLYDEFVKSVLKIVEKLDLTLEIQTVGEQENGDEAPGV WMIPTSDPAANLHPAKPKDFSAFINLVEFCREILPEKQAEFFEPWVYSFSYELILQSTRL PLISGFYKLLSITVRNAKKIKYFEGVSPKSLKHSPEDPEKYSCFALFVKFGKEVAVKMKQ YKDELLASCLTFLLSLPHNIIELDVRAYVPALQMAFKLGLSYTPLAEVGLNALEEWSIYI DRHVMQPYYKDILPCLDGYLKTSALSDETKNNWEVSALSRAAQKGFNKVVLKHLKKTKNL SSNEAISLEEIRIRVVQMLGSLGGQINKNLLTVTSSDEMMKSYVAWDREKRLSFAVPFRE MKPVIFLDVFLPRVTELALTASDRQTKVAACELLHSMVMFMLGKATQMPEGGQGAPPMYQ LYKRTFPVLLRLACDVDQVTRQLYEPLVMQLIHWFTNNKKFESQDTVALLEAILDGIVDP VDSTLRDFCGRCIREFLKWSIKQITPQQQEKSPVNTKSLFKRLYSLALHPNAFKRLGASL AFNNIYREFREEESLVEQFVFEALVIYMESLALAHADEKSLGTIQQCCDAIDHLCRIIEK KHVSLNKAKKRRLPRGFPPSASLCLLDLVKWLLAHCGRPQTECRHKSIELFYKFVPLLPG NRSPNLWLKDVLKEEGVSFLINTFEGGGCGQPSGILAQPTLLYLRGPFSLQATLCWLDLL LAALECYNTFIGERTVGALQVLGTEAQSSLLKAVAFFLESIAMHDIIAAEKCFGTGAAGN RTSPQEGERYNYSKCTVVVRIMEFTTTLLNTSPEGWKLLKKDLCNTHLMRVLVQTLCEPA SIGFNIGDVQVMAHLPDVCVNLMKALKMSPYKDILETHLREKITAQSIEELCAVNLYGPD AQVDRSRLAAVVSACKQLHRAGLLHNILPSQSTDLHHSVGTELLSLVYKGIAPGDERQCL PSLDLSCKQLASGLLELAFAFGGLCERLVSLLLNPAVLSTASLGSSQGSVIHFSHGEYFY SLFSETINTELLKNLDLAVLELMQSSVDNTKMVSAVLNGMLDQSFRERANQKHQGLKLAT TILQHWKKCDSWWAKDSPLETKMAVLALLAKILQIDSSVSFNTSHGSFPEVFTTYISLLA DTKLDLHLKGQAVTLLPFFTSLTGGSLEELRRVLEQLIVAHFPMQSREFPPGTPRFNNYV DCMKKFLDALELSQSPMLLELMTEVLCREQQHVMEELFQSSFRRIARRGSCVTQVGLLES VYEMFRKDDPRLSFTRQSFVDRSLLTLLWHCSLDALREFFSTIVVDAIDVLKSRFTKLNE STFDTQITKKMGYYKILDVMYSRLPKDDVHAKESKINQVFHGSCITEGNELTKTLIKLCY DAFTENMAGENQLLERRRLYHCAAYNCAISVICCVFNELKFYQGFLFSEKPEKNLLIFEN LIDLKRRYNFPVEVEVPMERKKKYIEIRKEAREAANGDSDGPSYMSSLSYLADSTLSEEM SQFDFSTGVQSYSYSSQDPRPATGRFRRREQRDPTVHDDVLELEMDELNRHECMAPLTAL VKHMHRSLGPPQGEEDSVPRDLPSWMKFLHGKLGNPIVPLNIRLFLAKLVINTEEVFRPY AKHWLSPLLQLAASENNGGEGIHYMVVEIVATILSWTGLATPTGVPKDEVLANRLLNFLM KHVFHPKRAVFRHNLEIIKTLVECWKDCLSIPYRLIFEKFSGKDPNSKDNSVGIQLLGIV MANDLPPYDPQCGIQSSEYFQALVNNMSFVRYKEVYAAAAEVLGLILRYVMERKNILEES LCELVAKQLKQHQNTMEDKFIVCLNKVTKSFPPLADRFMNAVFFLLPKFHGVLKTLCLEV VLCRVEGMTELYFQLKSKDFVQVMRHRDDERQKVCLDIIYKMMPKLKPVELRELLNPVVE FVSHPSTTCREQMYNILMWIHDNYRDPESETDNDSQEIFKLAKDVLIQGLIDENPGLQLI IRNFWSHETRLPSNTLDRLLALNSLYSPKIEVHFLSLATNFLLEMTSMSPDYPNPMFEHP LSECEFQEYTIDSDWRFRSTVLTPMFVETQASQGTLQTRTQEGSLSARWPVAGQIRATQQ QHDFTLTQTADGRSSFDWLTGSSTDPLVDHTSPSSDSLLFAHKRSERLQRAPLKSVGPDF GKKRLGLPGDEVDNKVKGAAGRTDLLRLRRRFMRDQEKLSLMYARKGVAEQKREKEIKSE LKMKQDAQVVLYRSYRHGDLPDIQIKHSSLITPLQAVAQRDPIIAKQLFSSLFSGILKEM DKFKTLSEKNNITQKLLQDFNRFLNTTFSFFPPFVSCIQDISCQHAALLSLDPAAVSAGC LASLQQPVGIRLLEEALLRLLPAELPAKRVRGKARLPPDVLRWVELAKLYRSIGEYDVLR GIFTSEIGTKQITQSALLAEARSDYSEAAKQYDEALNKQDWVDGEPTEAEKDFWELASLD CYNHLAEWKSLEYCSTASIDSENPPDLNKIWSEPFYQETYLPYMIRSKLKLLLQGEADQS LLTFIDKAMHGELQKAILELHYSQELSLLYLLQDDVDRAKYYIQNGIQSFMQNYSSIDVL LHQSRLTKLQSVQALTEIQEFISFISKQGNLSSQVPLKRLLNTWTNRYPDAKMDPMNIWD DIITNRCFFLSKIEEKLTPLPEDNSMNVDQDGDPSDRMEVQEQEEDISSLIRSCKFSMKM KMIDSARKQNNFSLAMKLLKELHKESKTRDDWLVSWVQSYCRLSHCRSRSQGCSEQVLTV LKTVSLLDENNVSSYLSKNILAFRDQNILLGTTYRIIANALSSEPACLAEIEEDKARRIL ELSGSSSEDSEKVIAGLYQRAFQHLSEAVQAAEEEAQPPSWSCGPAAGVIDAYMTLADFC DQQLRKEEENASVIDSAELQAYPALVVEKMLKALKLNSNEARLKFPRLLQIIERYPEETL SLMTKEISSVPCWQFISWISHMVALLDKDQAVAVQHSVEEITDNYPQAIVYPFIISSESY SFKDTSTGHKNKEFVARIKSKLDQGGVIQDFINALDQLSNPELLFKDWSNDVRAELAKTP VNKKNIEKMYERMYAALGDPKAPGLGAFRRKFIQTFGKEFDKHFGKGGSKLLRMKLSDFN DITNMLLLKMNKDSKPPGNLKECSPWMSDFKVEFLRNELEIPGQYDGRGKPLPEYHVRIA GFDERVTVMASLRRPKRIIIRGHDEREHPFLVKGGEDLRQDQRVEQLFQVMNGILAQDSA CSQRALQLRTYSVVPMTSRLGLIEWLENTVTLKDLLLNTMSQEEKAAYLSDPRAPPCEYK DWLTKMSGKHDVGAYMLMYKGANRTETVTSFRKRESKVPADLLKRAFVRMSTSPEAFLAL RSHFASSHALICISHWILGIGDRHLNNFMVAMETGGVIGIDFGHAFGSATQFLPVPELMP FRLTRQFINLMLPMKETGLMYSIMVHALRAFRSDPGLLTNTMDVFVKEPSFDWKNFEQKM LKKGGSWIQEINVAEKNWYPRQKICYAKRKLAGANPAVITCDELLLGHEKAPAFRDYVAV ARGSKDHNIRAQEPESGLSEETQVKCLMDQATDPNILGRTWEGWEPWM
Number of residues	4128
Molecular Weight	469084.155
Theoretical pI	7.12
GO Classification	Functions protein serine/threonine kinase activity transcription factor binding poly(A) RNA binding DNA-dependent protein kinase activity double-stranded DNA binding ATP binding protein kinase activity Processes response to activity pro-B cell differentiation protein destabilization cellular response to insulin stimulus signal transduction involved in mitotic G1 DNA damage checkpoint DNA repair ectopic germ cell programmed cell death brain development T cell lineage commitment double-strand break repair via nonhomologous end joining T cell receptor V(D)J recombination rhythmic process positive regulation of developmental growth telomere maintenance positive regulation of fibroblast proliferation peptidyl-serine phosphorylation spleen development regulation of circadian rhythm cellular protein modification process negative regulation of immunoglobulin production response to gamma radiation double-strand break repair negative regulation of protein phosphorylation double-strand break repair via homologous recombination innate immune response somitogenesis intrinsic apoptotic signaling pathway in response to DNA damage positive regulation of immune system process positive regulation of apoptotic process negative regulation of cellular senescence positive regulation of type I interferon production heart development B cell lineage commitment regulation of smooth muscle cell proliferation negative regulation of apoptotic process immunoglobulin V(D)J recombination T cell differentiation in thymus positive regulation of transcription from RNA polymerase II promoter negative regulation of response to gamma radiation thymus development Components nuclear chromosome, telomeric region cytosol nucleolus DNA-dependent protein kinase-DNA ligase 4 complex nonhomologous end joining complex nucleoplasm transcription factor complex membrane
General Function	Transcription factor binding
Specific Function	Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. Must be bound to DNA to express its catalytic properties. Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step. Required to protect and align broken ends of DNA. May also act as a scaffold protein to aid the localization of DNA repair proteins to the site of damage. Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion. Also involved in modulation of transcription. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX, thereby regulating DNA damage response mechanism. Phosphorylates DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, SRF, XRCC1, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2. Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA. Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D. Contributes to the determination of the circadian period length by antagonizing phosphorylation of CRY1 'Ser-588' and increasing CRY1 protein stability, most likely through an indirect machanism. Interacts with CRY1 and CRY2; negatively regulates CRY1 phosphorylation.
Pfam Domain Function	PI3_PI4_kinase (PF00454 ) FAT (PF02259 ) FATC (PF02260 ) NUC194 (PF08163 )
Transmembrane Regions	Not Available
GenBank Protein ID	Not Available
UniProtKB ID	P78527
UniProtKB Entry Name	PRKDC_HUMAN
Cellular Location	Nucleus
Gene sequence	>lcl\|BSEQ0016774\|DNA-dependent protein kinase catalytic subunit (PRKDC) ATGGCGGGCTCCGGAGCCGGTGTGCGTTGCTCCCTGCTGCGGCTGCAGGAGACCTTGTCC GCTGCGGACCGCTGCGGTGCTGCCCTGGCCGGTCATCAACTGATCCGCGGCCTGGGGCAG GAATGCGTCCTGAGCAGCAGCCCCGCGGTGCTGGCATTACAGACATCTTTAGTTTTTTCC AGAGATTTCGGTTTGCTTGTATTTGTCCGGAAGTCACTCAACAGTATTGAATTTCGTGAA TGTAGAGAAGAAATCCTAAAGTTTTTATGTATTTTCTTAGAAAAAATGGGCCAGAAGATC GCACCTTACTCTGTTGAAATTAAGAACACTTGTACCAGTGTTTATACAAAAGATAGAGCT GCTAAATGTAAAATTCCAGCCCTGGACCTTCTTATTAAGTTACTTCAGACTTTTAGAAGT TCTAGACTCATGGATGAATTTAAAATTGGAGAATTATTTAGTAAATTCTATGGAGAACTT GCATTGAAAAAAAAAATACCAGATACAGTTTTAGAAAAAGTATATGAGCTCCTAGGATTA TTGGGTGAAGTTCATCCTAGTGAGATGATAAATAATGCAGAAAACCTGTTCCGCGCTTTT CTGGGTGAACTTAAGACCCAGATGACATCAGCAGTAAGAGAGCCCAAACTACCTGTTCTG GCAGGATGTCTGAAGGGGTTGTCCTCACTTCTGTGCAACTTCACTAAGTCCATGGAAGAA GATCCCCAGACTTCAAGGGAGATTTTTAATTTTGTACTAAAGGCAATTCGTCCTCAGATT GATCTGAAGAGATATGCTGTGCCCTCAGCTGGCTTGCGCCTATTTGCCCTGCATGCATCT CAGTTTAGCACCTGCCTTCTGGACAACTACGTGTCTCTATTTGAAGTCTTGTTAAAGTGG TGTGCCCACACAAATGTAGAATTGAAAAAAGCTGCACTTTCAGCCCTGGAATCCTTTCTG AAACAGGTTTCTAATATGGTGGCGAAAAATGCAGAAATGCATAAAAATAAACTGCAGTAC TTTATGGAGCAGTTTTATGGAATCATCAGAAATGTGGATTCGAACAACAAGGAGTTATCT ATTGCTATCCGTGGATATGGACTTTTTGCAGGACCGTGCAAGGTTATAAACGCAAAAGAT GTTGACTTCATGTACGTTGAGCTCATTCAGCGCTGCAAGCAGATGTTCCTCACCCAGACA GACACTGGTGACGACCGTGTTTATCAGATGCCAAGCTTCCTCCAGTCTGTTGCAAGCGTC TTGCTGTACCTTGACACAGTTCCTGAGGTGTATACTCCAGTTCTGGAGCACCTCGTGGTG ATGCAGATAGACAGTTTCCCACAGTACAGTCCAAAAATGCAGCTGGTGTGTTGCAGAGCC ATAGTGAAGGTGTTCCTAGCTTTGGCAGCAAAAGGGCCAGTTCTCAGGAATTGCATTAGT ACTGTGGTGCATCAGGGTTTAATCAGAATATGTTCTAAACCAGTGGTCCTTCCAAAGGGC CCTGAGTCTGAATCTGAAGACCACCGTGCTTCAGGGGAAGTCAGAACTGGCAAATGGAAG GTGCCCACATACAAAGACTACGTGGATCTCTTCAGACATCTCCTGAGCTCTGACCAGATG ATGGATTCTATTTTAGCAGATGAAGCATTTTTCTCTGTGAATTCCTCCAGTGAAAGTCTG AATCATTTACTTTATGATGAATTTGTAAAATCCGTTTTGAAGATTGTTGAGAAATTGGAT CTTACACTTGAAATACAGACTGTTGGGGAACAAGAGAATGGAGATGAGGCGCCTGGTGTT TGGATGATCCCAACTTCAGATCCAGCGGCTAACTTGCATCCAGCTAAACCTAAAGATTTT TCGGCTTTCATTAACCTGGTGGAATTTTGCAGAGAGATTCTCCCTGAGAAACAAGCAGAA TTTTTTGAACCATGGGTGTACTCATTTTCATATGAATTAATTTTGCAATCTACAAGGTTG CCCCTCATCAGTGGTTTCTACAAATTGCTTTCTATTACAGTAAGAAATGCCAAGAAAATA AAATATTTCGAGGGAGTTAGTCCAAAGAGTCTGAAACACTCTCCTGAAGACCCAGAAAAG TATTCTTGCTTTGCTTTATTTGTGAAATTTGGCAAAGAGGTGGCAGTTAAAATGAAGCAG TACAAAGATGAACTTTTGGCCTCTTGTTTGACCTTTCTTCTGTCCTTGCCACACAACATC ATTGAACTCGATGTTAGAGCCTACGTTCCTGCACTGCAGATGGCTTTCAAACTGGGCCTG AGCTATACCCCCTTGGCAGAAGTAGGCCTGAATGCTCTAGAAGAATGGTCAATTTATATT GACAGACATGTAATGCAGCCTTATTACAAAGACATTCTCCCCTGCCTGGATGGATACCTG AAGACTTCAGCCTTGTCAGATGAGACCAAGAATAACTGGGAAGTGTCAGCTCTTTCTCGG GCTGCCCAGAAAGGATTTAATAAAGTGGTGTTAAAGCATCTGAAGAAGACAAAGAACCTT TCATCAAACGAAGCAATATCCTTAGAAGAAATAAGAATTAGAGTAGTACAAATGCTTGGA TCTCTAGGAGGACAAATAAACAAAAATCTTCTGACAGTCACGTCCTCAGATGAGATGATG AAGAGCTATGTGGCCTGGGACAGAGAGAAGCGGCTGAGCTTTGCAGTGCCCTTTAGAGAG ATGAAACCTGTCATTTTCCTGGATGTGTTCCTGCCTCGAGTCACAGAATTAGCGCTCACA GCCAGTGACAGACAAACTAAAGTTGCAGCCTGTGAACTTTTACATAGCATGGTTATGTTT ATGTTGGGCAAAGCCACGCAGATGCCAGAAGGGGGACAGGGAGCCCCACCCATGTACCAG CTCTATAAGCGGACGTTTCCTGTGCTGCTTCGACTTGCGTGTGATGTTGATCAGGTGACA AGGCAACTGTATGAGCCACTAGTTATGCAGCTGATTCACTGGTTCACTAACAACAAGAAA TTTGAAAGTCAGGATACTGTTGCCTTACTAGAAGCTATATTGGATGGAATTGTGGACCCT GTTGACAGTACTTTAAGAGATTTTTGTGGTCGGTGTATTCGAGAATTCCTTAAATGGTCC ATTAAGCAAATAACACCACAGCAGCAGGAGAAGAGTCCAGTAAACACCAAATCGCTTTTC AAGCGACTTTATAGCCTTGCGCTTCACCCCAATGCTTTCAAGAGGCTGGGAGCATCACTT GCCTTTAATAATATCTACAGGGAATTCAGGGAAGAAGAGTCTCTGGTGGAACAGTTTGTG TTTGAAGCCTTGGTGATATACATGGAGAGTCTGGCCTTAGCACATGCAGATGAGAAGTCC TTAGGTACAATTCAACAGTGTTGTGATGCCATTGATCACCTATGCCGCATCATTGAAAAG AAGCATGTTTCTTTAAATAAAGCAAAGAAACGACGTTTGCCGCGAGGATTTCCACCTTCC GCATCATTGTGTTTATTGGATCTGGTCAAGTGGCTTTTAGCTCATTGTGGGAGGCCCCAG ACAGAATGTCGACACAAATCCATTGAACTCTTTTATAAATTCGTTCCTTTATTGCCAGGC AACAGATCCCCTAATTTGTGGCTGAAAGATGTTCTCAAGGAAGAAGGTGTCTCTTTTCTC ATCAACACCTTTGAGGGGGGTGGCTGTGGCCAGCCCTCGGGCATCCTGGCCCAGCCCACC CTCTTGTACCTTCGGGGGCCATTCAGCCTGCAGGCCACGCTATGCTGGCTGGACCTGCTC CTGGCCGCGTTGGAGTGCTACAACACGTTCATTGGCGAGAGAACTGTAGGAGCGCTCCAG GTCCTAGGTACTGAAGCCCAGTCTTCACTTTTGAAAGCAGTGGCTTTCTTCTTAGAAAGC ATTGCCATGCATGACATTATAGCAGCAGAAAAGTGCTTTGGCACTGGGGCAGCAGGTAAC AGAACAAGCCCACAAGAGGGAGAAAGGTACAACTACAGCAAATGCACCGTTGTGGTCCGG ATTATGGAGTTTACCACGACTCTGCTAAACACCTCCCCGGAAGGATGGAAGCTCCTGAAG AAGGACTTGTGTAATACACACCTGATGAGAGTCCTGGTGCAGACGCTGTGTGAGCCCGCA AGCATAGGTTTCAACATCGGAGACGTCCAGGTTATGGCTCATCTTCCTGATGTTTGTGTG AATCTGATGAAAGCTCTAAAGATGTCCCCATACAAAGATATCCTAGAGACCCATCTGAGA GAGAAAATAACAGCACAGAGCATTGAGGAGCTTTGTGCCGTCAACTTGTATGGCCCTGAC GCGCAAGTGGACAGGAGCAGGCTGGCTGCTGTTGTGTCTGCCTGTAAACAGCTTCACAGA GCTGGGCTTCTGCATAATATATTACCGTCTCAGTCCACAGATTTGCATCATTCTGTTGGC ACAGAACTTCTTTCCCTGGTTTATAAAGGCATTGCCCCTGGAGATGAGAGACAGTGTCTG CCTTCTCTAGACCTCAGTTGTAAGCAGCTGGCCAGCGGACTTCTGGAGTTAGCCTTTGCT TTTGGAGGACTGTGTGAGCGCCTTGTGAGTCTTCTCCTGAACCCAGCGGTGCTGTCCACG GCGTCCTTGGGCAGCTCACAGGGCAGCGTCATCCACTTCTCCCATGGGGAGTATTTCTAT AGCTTGTTCTCAGAAACGATCAACACGGAATTATTGAAAAATCTGGATCTTGCTGTATTG GAGCTCATGCAGTCTTCAGTGGATAATACCAAAATGGTGAGTGCCGTTTTGAACGGCATG TTAGACCAGAGCTTCAGGGAGCGAGCAAACCAGAAACACCAAGGACTGAAACTTGCGACT ACAATTCTGCAACACTGGAAGAAGTGTGATTCATGGTGGGCCAAAGATTCCCCTCTCGAA ACTAAAATGGCAGTGCTGGCCTTACTGGCAAAAATTTTACAGATTGATTCATCTGTATCT TTTAATACAAGTCATGGTTCATTCCCTGAAGTCTTTACAACATATATTAGTCTACTTGCT GACACAAAGCTGGATCTACATTTAAAGGGCCAAGCTGTCACTCTTCTTCCATTCTTCACC AGCCTCACTGGAGGCAGTCTGGAGGAACTTAGACGTGTTCTGGAGCAGCTCATCGTTGCT CACTTCCCCATGCAGTCCAGGGAATTTCCTCCAGGAACTCCGCGGTTCAATAATTATGTG GACTGCATGAAAAAGTTTCTAGATGCATTGGAATTATCTCAAAGCCCTATGTTGTTGGAA TTGATGACAGAAGTTCTTTGTCGGGAACAGCAGCATGTCATGGAAGAATTATTTCAATCC AGTTTCAGGAGGATTGCCAGAAGGGGTTCATGTGTCACACAAGTAGGCCTTCTGGAAAGC GTGTATGAAATGTTCAGGAAGGATGACCCCCGCCTAAGTTTCACACGCCAGTCCTTTGTG GACCGCTCCCTCCTCACTCTGCTGTGGCACTGTAGCCTGGATGCTTTGAGAGAATTCTTC AGCACAATTGTGGTGGATGCCATTGATGTGTTGAAGTCCAGGTTTACAAAGCTAAATGAA TCTACCTTTGATACTCAAATCACCAAGAAGATGGGCTACTATAAGATTCTAGACGTGATG TATTCTCGCCTTCCCAAAGATGATGTTCATGCTAAGGAATCAAAAATTAATCAAGTTTTC CATGGCTCGTGTATTACAGAAGGAAATGAACTTACAAAGACATTGATTAAATTGTGCTAC GATGCATTTACAGAGAACATGGCAGGAGAGAATCAGCTGCTGGAGAGGAGAAGACTTTAC CATTGTGCAGCATACAACTGCGCCATATCTGTCATCTGCTGTGTCTTCAATGAGTTAAAA TTTTACCAAGGTTTTCTGTTTAGTGAAAAACCAGAAAAGAACTTGCTTATTTTTGAAAAT CTGATCGACCTGAAGCGCCGCTATAATTTTCCTGTAGAAGTTGAGGTTCCTATGGAAAGA AAGAAAAAGTACATTGAAATTAGGAAAGAAGCCAGAGAAGCAGCAAATGGGGATTCAGAT GGTCCTTCCTATATGTCTTCCCTGTCATATTTGGCAGACAGTACCCTGAGTGAGGAAATG AGTCAATTTGATTTCTCAACCGGAGTTCAGAGCTATTCATACAGCTCCCAAGACCCTAGA CCTGCCACTGGTCGTTTTCGGAGACGGGAGCAGCGGGACCCCACGGTGCATGATGATGTG CTGGAGCTGGAGATGGACGAGCTCAATCGGCATGAGTGCATGGCGCCCCTGACGGCCCTG GTCAAGCACATGCACAGAAGCCTGGGCCCGCCTCAAGGAGAAGAGGATTCAGTGCCAAGA GATCTTCCTTCTTGGATGAAATTCCTCCATGGCAAACTGGGAAATCCAATAGTACCATTA AATATCCGTCTCTTCTTAGCCAAGCTTGTTATTAATACAGAAGAGGTCTTTCGCCCTTAC GCGAAGCACTGGCTTAGCCCCTTGCTGCAGCTGGCTGCTTCTGAAAACAATGGAGGAGAA GGAATTCACTACATGGTGGTTGAGATAGTGGCCACTATTCTTTCATGGACAGGCTTGGCC ACTCCAACAGGGGTCCCTAAAGATGAAGTGTTAGCAAATCGATTGCTTAATTTCCTAATG AAACATGTCTTTCATCCAAAAAGAGCTGTGTTTAGACACAACCTTGAAATTATAAAGACC CTTGTCGAGTGCTGGAAGGATTGTTTATCCATCCCTTATAGGTTAATATTTGAAAAGTTT TCCGGTAAAGATCCTAATTCTAAAGACAACTCAGTAGGGATTCAATTGCTAGGCATCGTG ATGGCCAATGACCTGCCTCCCTATGACCCACAGTGTGGCATCCAGAGTAGCGAATACTTC CAGGCTTTGGTGAATAATATGTCCTTTGTAAGATATAAAGAAGTGTATGCCGCTGCAGCA GAAGTTCTAGGACTTATACTTCGATATGTTATGGAGAGAAAAAACATACTGGAGGAGTCT CTGTGTGAACTGGTTGCGAAACAATTGAAGCAACATCAGAATACTATGGAGGACAAGTTT ATTGTGTGCTTGAACAAAGTGACCAAGAGCTTCCCTCCTCTTGCAGACAGGTTCATGAAT GCTGTGTTCTTTCTGCTGCCAAAATTTCATGGAGTGTTGAAAACACTCTGTCTGGAGGTG GTACTTTGTCGTGTGGAGGGAATGACAGAGCTGTACTTCCAGTTAAAGAGCAAGGACTTC GTTCAAGTCATGAGACATAGAGATGATGAAAGACAAAAAGTATGTTTGGACATAATTTAT AAGATGATGCCAAAGTTAAAACCAGTAGAACTCCGAGAACTTCTGAACCCCGTTGTGGAA TTCGTTTCCCATCCTTCTACAACATGTAGGGAACAAATGTATAATATTCTCATGTGGATT CATGATAATTACAGAGATCCAGAAAGTGAGACAGATAATGACTCCCAGGAAATATTTAAG TTGGCAAAAGATGTGCTGATTCAAGGATTGATCGATGAGAACCCTGGACTTCAATTAATT ATTCGAAATTTCTGGAGCCATGAAACTAGGTTACCTTCAAATACCTTGGACCGGTTGCTG GCACTAAATTCCTTATATTCTCCTAAGATAGAAGTGCACTTTTTAAGTTTAGCAACAAAT TTTCTGCTCGAAATGACCAGCATGAGCCCAGATTATCCAAACCCCATGTTCGAGCATCCT CTGTCAGAATGCGAATTTCAGGAATATACCATTGATTCTGATTGGCGTTTCCGAAGTACT GTTCTCACTCCGATGTTTGTGGAGACCCAGGCCTCCCAGGGCACTCTCCAGACCCGTACC CAGGAAGGGTCCCTCTCAGCTCGCTGGCCAGTGGCAGGGCAGATAAGGGCCACCCAGCAG CAGCATGACTTCACACTGACACAGACTGCAGATGGAAGAAGCTCATTTGATTGGCTGACC GGGAGCAGCACTGACCCGCTGGTCGACCACACCAGTCCCTCATCTGACTCCTTGCTGTTT GCCCACAAGAGGAGTGAAAGGTTACAGAGAGCACCCTTGAAGTCAGTGGGGCCTGATTTT GGGAAAAAAAGGCTGGGCCTTCCAGGGGACGAGGTGGATAACAAAGTGAAAGGTGCGGCC GGCCGGACGGACCTACTACGACTGCGCAGACGGTTTATGAGGGACCAGGAGAAGCTCAGT TTGATGTATGCCAGAAAAGGCGTTGCTGAGCAAAAACGAGAGAAGGAAATCAAGAGTGAG TTAAAAATGAAGCAGGATGCCCAGGTCGTTCTGTACAGAAGCTACCGGCACGGAGACCTT CCTGACATTCAGATCAAGCACAGCAGCCTCATCACCCCGTTACAGGCCGTGGCCCAGAGG GACCCAATAATTGCAAAACAGCTCTTTAGCAGCTTGTTTTCTGGAATTTTGAAAGAGATG GATAAATTTAAGACACTGTCTGAAAAAAACAACATCACTCAAAAGTTGCTTCAAGACTTC AATCGTTTTCTTAATACCACCTTCTCTTTCTTTCCACCCTTTGTCTCTTGTATTCAGGAC ATTAGCTGTCAGCACGCAGCCCTGCTGAGCCTCGACCCAGCGGCTGTTAGCGCTGGTTGC CTGGCCAGCCTACAGCAGCCCGTGGGCATCCGCCTGCTAGAGGAGGCTCTGCTCCGCCTG CTGCCTGCTGAGCTGCCTGCCAAGCGAGTCCGTGGGAAGGCCCGCCTCCCTCCTGATGTC CTCAGATGGGTGGAGCTTGCTAAGCTGTATAGATCAATTGGAGAATACGACGTCCTCCGT GGGATTTTTACCAGTGAGATAGGAACAAAGCAAATCACTCAGAGTGCATTATTAGCAGAA GCCAGAAGTGATTATTCTGAAGCTGCTAAGCAGTATGATGAGGCTCTCAATAAACAAGAC TGGGTAGATGGTGAGCCCACAGAAGCCGAGAAGGATTTTTGGGAACTTGCATCCCTTGAC TGTTACAACCACCTTGCTGAGTGGAAATCACTTGAATACTGTTCTACAGCCAGTATAGAC AGTGAGAACCCCCCAGACCTAAATAAAATCTGGAGTGAACCATTTTATCAGGAAACATAT CTACCTTACATGATCCGCAGCAAGCTGAAGCTGCTGCTCCAGGGAGAGGCTGACCAGTCC CTGCTGACATTTATTGACAAAGCTATGCACGGGGAGCTCCAGAAGGCGATTCTAGAGCTT CATTACAGTCAAGAGCTGAGTCTGCTTTACCTCCTGCAAGATGATGTTGACAGAGCCAAA TATTACATTCAAAATGGCATTCAGAGTTTTATGCAGAATTATTCTAGTATTGATGTCCTC TTACACCAAAGTAGACTCACCAAATTGCAGTCTGTACAGGCTTTAACAGAAATTCAGGAG TTCATCAGCTTTATAAGCAAACAAGGCAATTTATCATCTCAAGTTCCCCTTAAGAGACTT CTGAACACCTGGACAAACAGATATCCAGATGCTAAAATGGACCCAATGAACATCTGGGAT GACATCATCACAAATCGATGTTTCTTTCTCAGCAAAATAGAGGAGAAGCTTACCCCTCTT CCAGAAGATAATAGTATGAATGTGGATCAAGATGGAGACCCCAGTGACAGGATGGAAGTG CAAGAGCAGGAAGAAGATATCAGCTCCCTGATCAGGAGTTGCAAGTTTTCCATGAAAATG AAGATGATAGACAGTGCCCGGAAGCAGAACAATTTCTCACTTGCTATGAAACTACTGAAG GAGCTGCATAAAGAGTCAAAAACCAGAGACGATTGGCTGGTGAGCTGGGTGCAGAGCTAC TGCCGCCTGAGCCACTGCCGGAGCCGGTCCCAGGGCTGCTCTGAGCAGGTGCTCACTGTG CTGAAAACAGTCTCTTTGTTGGATGAGAACAACGTGTCAAGCTACTTAAGCAAAAATATT CTGGCTTTCCGTGACCAGAACATTCTCTTGGGTACAACTTACAGGATCATAGCGAATGCT CTCAGCAGTGAGCCAGCCTGCCTTGCTGAAATCGAGGAGGACAAGGCTAGAAGAATCTTA GAGCTTTCTGGATCCAGTTCAGAGGATTCAGAGAAGGTGATCGCGGGTCTGTACCAGAGA GCATTCCAGCACCTCTCTGAGGCTGTGCAGGCGGCTGAGGAGGAGGCCCAGCCTCCCTCC TGGAGCTGTGGGCCTGCAGCTGGGGTGATTGATGCTTACATGACGCTGGCAGATTTCTGT GACCAACAGCTGCGCAAGGAGGAAGAGAATGCATCAGTTATTGATTCTGCAGAACTGCAG GCGTATCCAGCACTTGTGGTGGAGAAAATGTTGAAAGCTTTAAAATTAAATTCCAATGAA GCCAGATTGAAGTTTCCTAGATTACTTCAGATTATAGAACGGTATCCAGAGGAGACTTTG AGCCTCATGACAAAAGAGATCTCTTCCGTTCCCTGCTGGCAGTTCATCAGCTGGATCAGC CACATGGTGGCCTTACTGGACAAAGACCAAGCCGTTGCTGTTCAGCACTCTGTGGAAGAA ATCACTGATAACTACCCGCAGGCTATTGTTTATCCCTTCATCATAAGCAGCGAAAGCTAT TCCTTCAAGGATACTTCTACTGGTCATAAGAATAAGGAGTTTGTGGCAAGGATTAAAAGT AAGTTGGATCAAGGAGGAGTGATTCAAGATTTTATTAATGCCTTAGATCAGCTCTCTAAT CCTGAACTGCTCTTTAAGGATTGGAGCAATGATGTAAGAGCTGAACTAGCAAAAACCCCT GTAAATAAAAAAAACATTGAAAAAATGTATGAAAGAATGTATGCAGCCTTGGGTGACCCA AAGGCTCCAGGCCTGGGGGCCTTTAGAAGGAAGTTTATTCAGACTTTTGGAAAAGAATTT GATAAACATTTTGGGAAAGGAGGTTCTAAACTACTGAGAATGAAGCTCAGTGACTTCAAC GACATTACCAACATGCTACTTTTAAAAATGAACAAAGACTCAAAGCCCCCTGGGAATCTG AAAGAATGTTCACCCTGGATGAGCGACTTCAAAGTGGAGTTCCTGAGAAATGAGCTGGAG ATTCCCGGTCAGTATGACGGTAGGGGAAAGCCATTGCCAGAGTACCACGTGCGAATCGCC GGGTTTGATGAGCGGGTGACAGTCATGGCGTCTCTGCGAAGGCCCAAGCGCATCATCATC CGTGGCCATGACGAGAGGGAACACCCTTTCCTGGTGAAGGGTGGCGAGGACCTGCGGCAG GACCAGCGCGTGGAGCAGCTCTTCCAGGTCATGAATGGGATCCTGGCCCAAGACTCCGCC TGCAGCCAGAGGGCCCTGCAGCTGAGGACCTATAGCGTTGTGCCCATGACCTCCAGTGAT CCCAGGGCACCGCCGTGTGAATATAAAGATTGGCTGACAAAAATGTCAGGAAAACATGAT GTTGGAGCTTACATGCTAATGTATAAGGGCGCTAATCGTACTGAAACAGTCACGTCTTTT AGAAAACGAGAAAGTAAAGTGCCTGCTGATCTCTTAAAGCGGGCCTTCGTGAGGATGAGT ACAAGCCCTGAGGCTTTCCTGGCGCTCCGCTCCCACTTCGCCAGCTCTCACGCTCTGATA TGCATCAGCCACTGGATCCTCGGGATTGGAGACAGACATCTGAACAACTTTATGGTGGCC ATGGAGACTGGCGGCGTGATCGGGATCGACTTTGGGCATGCGTTTGGATCCGCTACACAG TTTCTGCCAGTCCCTGAGTTGATGCCTTTTCGGCTAACTCGCCAGTTTATCAATCTGATG TTACCAATGAAAGAAACGGGCCTTATGTACAGCATCATGGTACACGCACTCCGGGCCTTC CGCTCAGACCCTGGCCTGCTCACCAACACCATGGATGTGTTTGTCAAGGAGCCCTCCTTT GATTGGAAAAATTTTGAACAGAAAATGCTGAAAAAAGGAGGGTCATGGATTCAAGAAATA AATGTTGCTGAAAAAAATTGGTACCCCCGACAGAAAATATGTTACGCTAAGAGAAAGTTA GCAGGTGCCAATCCAGCAGTCATTACTTGTGATGAGCTACTCCTGGGTCATGAGAAGGCC CCTGCCTTCAGAGACTATGTGGCTGTGGCACGAGGAAGCAAAGATCACAACATTCGTGCC CAAGAACCAGAGAGTGGGCTTTCAGAAGAGACTCAAGTGAAGTGCCTGATGGACCAGGCA ACAGACCCCAACATCCTTGGCAGAACCTGGGAAGGATGGGAGCCCTGGATGTGA
GenBank Gene ID	U47077
GeneCard ID	Not Available
GenAtlas ID	PRKDC
HGNC ID	HGNC:9413
Chromosome Location	8
Locus	8q11
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