NameDisks large homolog 4
Synonyms
  • Postsynaptic density protein 95
  • PSD-95
  • PSD95
  • SAP-90
  • SAP90
  • Synapse-associated protein 90
Gene NameDLG4
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009445|Disks large homolog 4
MDCLCIVTTKKYRYQDEDTPPLEHSPAHLPNQANSPPVIVNTDTLEAPGYELQVNGTEGE
MEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFV
NEVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKGPKGLGFSIAGGVGN
QHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVY
LKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKD
LLGEEDIPREPRRIVIHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQIL
SVNGVDLRNASHEQAAIALKNAGQTVTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGT
ASLRSNPKRGFYIRALFDYDKTKDCGFLSQALSFRFGDVLHVIDASDEEWWQARRVHSDS
ETDDIGFIPSKRRVERREWSRLKAKDWGSSSGSQGREDSVLSYETVTQMEVHYARPIIIL
GPTKDRANDDLLSEFPDKFGSCVPHTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIE
AGQYNSHLYGTSVQSVREVAEQGKHCILDVSANAVRRLQAAHLHPIAIFIRPRSLENVLE
INKRITEEQARKAFDRATKLEQEFTECFSAIVEGDSFEEIYHKVKRVIEDLSGPYIWVPA
RERL
Number of residues724
Molecular Weight80494.615
Theoretical pINot Available
GO Classification
Functions
  • P2Y1 nucleotide receptor binding
  • PDZ domain binding
  • protein C-terminus binding
  • kinase binding
  • guanylate kinase activity
  • acetylcholine receptor binding
  • scaffold protein binding
  • beta-1 adrenergic receptor binding
  • D1 dopamine receptor binding
  • protein complex binding
  • ionotropic glutamate receptor binding
  • neuroligin family protein binding
  • protein phosphatase binding
Processes
  • neurotrophin TRK receptor signaling pathway
  • establishment of protein localization
  • positive regulation of excitatory postsynaptic potential
  • Ras protein signal transduction
  • AMPA glutamate receptor clustering
  • vascular endothelial growth factor receptor signaling pathway
  • dendritic spine morphogenesis
  • protein complex assembly
  • GDP metabolic process
  • nervous system development
  • protein localization to synapse
  • positive regulation of synaptic transmission
  • receptor localization to synapse
  • regulation of grooming behavior
  • locomotory exploration behavior
  • learning
  • axon guidance
  • synaptic vesicle maturation
  • regulation of N-methyl-D-aspartate selective glutamate receptor activity
  • epidermal growth factor receptor signaling pathway
  • vocalization behavior
  • social behavior
  • innate immune response
  • negative regulation of receptor internalization
  • signal transduction
  • positive regulation of cytosolic calcium ion concentration
  • Fc-epsilon receptor signaling pathway
  • GMP metabolic process
  • neuromuscular process controlling balance
  • activation of MAPKK activity
  • fibroblast growth factor receptor signaling pathway
  • regulation of long-term neuronal synaptic plasticity
  • insulin receptor signaling pathway
  • small GTPase mediated signal transduction
  • MAPK cascade
  • synaptic transmission
Components
  • synaptic vesicle
  • AMPA glutamate receptor complex
  • cell junction
  • neuron spine
  • synapse
  • excitatory synapse
  • cytosol
  • postsynaptic density
  • extrinsic component of cytoplasmic side of plasma membrane
  • dendrite cytoplasm
  • neuronal postsynaptic density
  • cytoplasm
  • cortical cytoskeleton
  • neuron projection terminus
  • endocytic vesicle membrane
  • postsynaptic membrane
  • endoplasmic reticulum
  • plasma membrane
  • cerebellar mossy fiber
  • dendritic spine
  • juxtaparanode region of axon
General FunctionScaffold protein binding
Specific FunctionInteracts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity).
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDP78352
UniProtKB Entry NameDLG4_HUMAN
Cellular LocationCell membrane
Gene sequence
>lcl|BSEQ0013164|Disks large homolog 4 (DLG4)
ATGGACTGTCTCTGTATAGTGACAACCAAGAAATACCGCTACCAAGATGAAGACACGCCC
CCTCTGGAGCACAGCCCGGCCCACCTCCCCAACCAGGCCAATTCTCCCCCAGTGATTGTC
AACACAGATACCCTAGAAGCCCCAGGATATGTGAACGGGACCGAGGGGGAGATGGAATAC
GAGGAAATCACATTGGAAAGGGGTAACTCAGGTCTGGGCTTCAGCATCGCAGGTGGCACT
GACAACCCACACATCGGTGACGACCCATCCATTTTCATCACCAAGATCATTCCTGGTGGG
GCTGCGGCCCAGGATGGCCGCCTCAGGGTCAACGACAGCATCCTGTTTGTAAATGAAGTG
GACGTGCGCGAGGTGACCCACTCAGCGGCGGTGGAAGCCCTCAAAGAGGCAGGCTCCATC
GTTCGCCTCTATGTCATGCGCCGGAAGCCCCCGGCTGAGAAGGTCATGGAGATCAAGCTC
ATCAAGGGGCCTAAAGGTCTTGGCTTCAGCATCGCAGGGGGCGTAGGGAACCAGCACATC
CCAGGAGATAATAGCATCTATGTAACAAAGATCATCGAAGGGGGTGCTGCCCACAAGGAT
GGGAGGTTGCAGATTGGAGACAAGATCCTGGCGGTCAACAGTGTGGGGCTAGAGGACGTC
ATGCATGAAGATGCTGTGGCAGCCCTGAAGAACACGTATGATGTTGTCTACCTAAAGGTG
GCCAAGCCCAGCAATGCCTACCTGAGTGACAGCTATGCTCCCCCAGACATCACAACCTCT
TATTCCCAGCACCTGGACAATGAGATCAGTCACAGCAGCTACCTGGGCACCGACTACCCC
ACAGCCATGACCCCCACTTCCCCTCGGCGCTACTCTCCAGTGGCCAAGGACCTGCTCGGG
GAGGAAGACATTCCCCGAGAACCGAGGCGAATTGTGATCCACCGGGGCTCCACGGGCCTG
GGCTTCAACATCGTGGGTGGCGAGGACGGTGAAGGCATCTTCATCTCCTTTATCCTGGCC
GGGGGCCCTGCAGACCTCAGTGGGGAGCTGCGGAAGGGGGACCAGATCCTGTCGGTCAAC
GGTGTGGACCTCCGAAATGCCAGCCATGAGCAGGCTGCCATTGCCCTGAAGAATGCGGGT
CAGACGGTCACGATCATCGCTCAGTATAAACCAGAAGAGTACAGCCGATTCGAGGCCAAG
ATCCACGACCTTCGGGAACAGCTCATGAACAGCAGCCTGGGCTCAGGGACTGCGTCCCTG
CGGAGCAACCCCAAAAGGGGTTTCTACATCAGGGCCCTGTTTGATTACGACAAGACCAAG
GACTGCGGCTTCCTGAGCCAGGCCCTGAGCTTCCGCTTTGGGGATGTGCTGCATGTCATC
GATGCTAGTGATGAGGAGTGGTGGCAGGCACGGCGGGTCCACTCTGACAGTGAGACCGAC
GACATTGGGTTCATCCCCAGCAAACGGCGGGTTGAGCGACGAGAGTGGTCAAGGTTAAAG
GCCAAGGACTGGGGCTCCAGCTCTGGATCGCAGGGTCGAGAAGACTCGGTTCTGAGCTAC
GAGACAGTGACGCAGATGGAAGTGCACTATGCTCGCCCCATCATCATCCTTGGGCCCACC
AAGGACCGCGCCAACGATGATCTTCTCTCCGAGTTCCCCGACAAGTTTGGATCCTGTGTT
CCCCATACGACACGGCCCAAGCGGGAGTATGAGATAGATGGCCGGGATTACCACTTTGTG
TCGTCCCGGGAGAAAATGGAGAAGGACATTCAGGCGCACAAGTTCATTGAGGCCGGCCAG
TACAACAGCCACCTCTATGGGACCAGCGTCCAGTCCGTGCGAGAGGTGGCAGAGCAGGGG
AAGCACTGCATCCTCGATGTCTCGGCCAATGCCGTGCGGCGGCTGCAGGCGGCCCACCTG
CACCCCATCGCCATCTTCATCCGCCCCCGCTCCCTGGAGAATGTGCTAGAGATTAACAAG
CGGATCACAGAGGAGCAAGCCCGCAAAGCCTTCGACAGAGCCACCAAGCTGGAGCAGGAG
TTCACAGAGTGCTTCTCAGCCATCGTGGAGGGTGACAGCTTTGAGGAGATCTACCACAAG
GTGAAGCGTGTCATCGAGGACCTCTCAGGCCCCTACATCTGGGTTCCAGCCCGAGAGAGA
CTCTGA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:2903
Chromosome Location17
LocusNot Available
References
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