Histone H3.1

NameHistone H3.1
Synonyms
  • H3FA
  • H3FB
  • H3FC
  • H3FD
  • H3FF
  • H3FH
  • H3FI
  • H3FJ
  • H3FK
  • H3FL
  • Histone H3/a
  • Histone H3/b
  • Histone H3/c
  • Histone H3/d
  • Histone H3/f
  • Histone H3/h
  • Histone H3/i
  • Histone H3/j
  • Histone H3/k
  • Histone H3/l
Gene NameHIST1H3A
OrganismHuman
Amino acid sequence
>lcl|BSEQ0017602|Histone H3.1
MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTE
LLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEACEAYLVGLFEDTNLCAIHAKRVTI
MPKDIQLARRIRGERA
Number of residues136
Molecular Weight15403.925
Theoretical pINot Available
GO Classification
Functions
  • DNA binding
  • histone binding
Processes
  • negative regulation of gene expression, epigenetic
  • regulation of gene expression, epigenetic
  • blood coagulation
  • chromatin organization
  • gene silencing by RNA
  • small GTPase mediated signal transduction
  • chromatin silencing at rDNA
  • gene expression
  • nucleosome assembly
  • DNA replication-dependent nucleosome assembly
  • regulation of gene silencing
  • cellular protein metabolic process
  • protein heterotetramerization
  • positive regulation of defense response to virus by host
  • xenophagy
  • DNA methylation on cytosine
Components
  • membrane
  • protein complex
  • extracellular region
  • nuclear chromosome
  • nuclear nucleosome
  • nucleus
  • nucleosome
  • extracellular exosome
  • nucleoplasm
General FunctionHistone binding
Specific FunctionCore component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDP68431
UniProtKB Entry NameH31_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0017603|Histone H3.1 (HIST1H3A)
ATGGCTCGCACTAAGCAAACTGCTCGGAAGTCTACTGGTGGCAAGGCGCCACGCAAACAG
TTGGCCACTAAGGCAGCCCGCAAAAGCGCTCCGGCCACCGGCGGCGTGAAAAAGCCCCAC
CGCTACCGGCCGGGCACCGTGGCTCTGCGCGAGATCCGCCGTTATCAGAAGTCCACTGAA
CTGCTTATTCGTAAACTACCTTTCCAGCGCCTGGTGCGCGAGATTGCGCAGGACTTTAAA
ACAGACCTGCGTTTCCAGAGCTCCGCTGTGATGGCTCTGCAGGAGGCGTGCGAGGCCTAC
TTGGTAGGGCTATTTGAGGACACTAACCTGTGCGCCATCCACGCCAAGCGCGTCACTATC
ATGCCCAAGGACATCCAGCTCGCCCGCCGCATCCGCGGAGAGAGGGCGTGA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:4766
Chromosome Location6
LocusNot Available
References
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