Guanine nucleotide-binding protein G(i) subunit alpha-1

NameGuanine nucleotide-binding protein G(i) subunit alpha-1
Synonyms
  • Adenylate cyclase-inhibiting G alpha protein
Gene NameGNAI1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009412|Guanine nucleotide-binding protein G(i) subunit alpha-1
MGCTLSAEDKAAVERSKMIDRNLREDGEKAAREVKLLLLGAGESGKSTIVKQMKIIHEAG
YSEEECKQYKAVVYSNTIQSIIAIIRAMGRLKIDFGDSARADDARQLFVLAGAAEEGFMT
AELAGVIKRLWKDSGVQACFNRSREYQLNDSAAYYLNDLDRIAQPNYIPTQQDVLRTRVK
TTGIVETHFTFKDLHFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSDYDLVLAEDEEM
NRMHESMKLFDSICNNKWFTDTSIILFLNKKDLFEEKIKKSPLTICYPEYAGSNTYEEAA
AYIQCQFEDLNKRKDTKEIYTHFTCATDTKNVQFVFDAVTDVIIKNNLKDCGLF
Number of residues354
Molecular Weight40360.685
Theoretical pINot Available
GO Classification
Functions
  • signal transducer activity
  • GTP binding
  • GTPase activity
  • GDP binding
  • G-protein beta/gamma-subunit complex binding
  • metal ion binding
  • G-protein coupled serotonin receptor binding
Processes
  • G-protein coupled receptor signaling pathway
  • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
  • adenylate cyclase-modulating G-protein coupled receptor signaling pathway
  • blood coagulation
  • synaptic transmission
  • negative regulation of synaptic transmission
  • cell division
  • cell cycle
  • platelet activation
  • response to peptide hormone
Components
  • membrane raft
  • cytoplasm
  • lysosomal membrane
  • centrosome
  • nucleus
  • midbody
  • plasma membrane
  • heterotrimeric G-protein complex
  • extracellular exosome
General FunctionSignal transducer activity
Specific FunctionGuanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDP63096
UniProtKB Entry NameGNAI1_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0017452|Guanine nucleotide-binding protein G(i) subunit alpha-1 (GNAI1)
ATGAAAATTATCCATGAAGCTGGTTATTCAGAAGAGGAGTGTAAACAATACAAAGCAGTG
GTCTACAGTAACACCATCCAGTCAATTATTGCTATCATTAGGGCTATGGGGAGGTTGAAG
ATAGACTTTGGTGACTCAGCCCGGGCGGATGATGCACGCCAACTCTTTGTGCTAGCTGGA
GCTGCTGAAGAAGGCTTTATGACTGCAGAACTTGCTGGAGTTATAAAGAGATTGTGGAAA
GATAGTGGTGTACAAGCCTGTTTCAACAGATCCCGAGAGTACCAGCTTAATGATTCTGCA
GCATACTATTTGAATGACTTGGACAGAATAGCTCAACCAAATTACATCCCGACTCAACAA
GATGTTCTCAGAACTAGAGTGAAAACTACAGGAATTGTTGAAACCCATTTTACTTTCAAA
GATCTTCATTTTAAAATGTTTGATGTGGGAGGTCAGAGATCTGAGCGGAAGAAGTGGATT
CATTGCTTCGAAGGAGTGACGGCGATCATCTTCTGTGTAGCACTGAGTGACTACGACCTG
GTTCTAGCTGAAGATGAAGAAATGAACCGAATGCATGAAAGCATGAAATTGTTTGACAGC
ATATGTAACAACAAGTGGTTTACAGATACATCCATTATACTTTTTCTAAACAAGAAGGAT
CTCTTTGAAGAAAAAATCAAAAAGAGCCCTCTCACTATATGCTATCCAGAATATGCAGGA
TCAAACACATATGAAGAGGCAGCTGCATATATTCAATGTCAGTTTGAAGACCTCAATAAA
AGAAAGGACACAAAGGAAATATACACCCACTTCACATGTGCCACAGATACTAAGAATGTG
CAGTTTGTTTTTGATGCTGTAACAGATGTCATCATAAAAAATAATCTAAAAGATTGTGGT
CTCTTTTAA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:4384
Chromosome Location7
LocusNot Available
References
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