Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

NameGuanine nucleotide-binding protein G(s) subunit alpha isoforms short
Synonyms
  • Adenylate cyclase-stimulating G alpha protein
  • GNAS1
  • GSP
Gene NameGNAS
OrganismHuman
Amino acid sequence
>lcl|BSEQ0007167|Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
MGCLGNSKTEDQRNEEKAQREANKKIEKQLQKDKQVYRATHRLLLLGAGESGKSTIVKQM
RILHVNGFNGEGGEEDPQAARSNSDGEKATKVQDIKNNLKEAIETIVAAMSNLVPPVELA
NPENQFRVDYILSVMNVPDFDFPPEFYEHAKALWEDEGVRACYERSNEYQLIDCAQYFLD
KIDVIKQADYVPSDQDLLRCRVLTSGIFETKFQVDKVNFHMFDVGGQRDERRKWIQCFND
VTAIIFVVASSSYNMVIREDNQTNRLQEALNLFKSIWNNRWLRTISVILFLNKQDLLAEK
VLAGKSKIEDYFPEFARYTTPEDATPEPGEDPRVTRAKYFIRDEFLRISTASGDGRHYCY
PHFTCAVDTENIRRVFNDCRDIIQRMHLRQYELL
Number of residues394
Molecular Weight45664.205
Theoretical pI5.56
GO Classification
Functions
  • signal transducer activity
  • GTP binding
  • GTPase activity
  • adenylate cyclase activity
  • metal ion binding
Processes
  • renal water homeostasis
  • water transport
  • positive regulation of cAMP-mediated signaling
  • transmembrane transport
  • activation of adenylate cyclase activity
  • adenylate cyclase-activating adrenergic receptor signaling pathway
  • energy reserve metabolic process
  • cAMP biosynthetic process
  • regulation of insulin secretion
  • developmental growth
  • cognition
  • cellular response to prostaglandin E stimulus
  • sensory perception of smell
  • platelet aggregation
  • hair follicle placode formation
  • positive regulation of GTPase activity
  • blood coagulation
  • positive regulation of cAMP biosynthetic process
  • adenylate cyclase-activating dopamine receptor signaling pathway
  • intracellular transport
  • adenylate cyclase-activating G-protein coupled receptor signaling pathway
  • cellular response to catecholamine stimulus
  • bone development
  • cellular response to glucagon stimulus
  • small molecule metabolic process
Components
  • cytosol
  • extracellular exosome
  • cytoplasm
  • membrane
  • intrinsic component of membrane
  • trans-Golgi network membrane
  • plasma membrane
  • heterotrimeric G-protein complex
General FunctionSignal transducer activity
Specific FunctionGuanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs) (PubMed:17110384). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP (PubMed:26206488, PubMed:8702665). GNAS functions downstream of several GPCRs, including beta-adrenergic receptors (PubMed:21488135). Stimulates the Ras signaling pathway via RAPGEF2 (PubMed:12391161).
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID31915
UniProtKB IDP63092
UniProtKB Entry NameGNAS2_HUMAN
Cellular LocationCell membrane
Gene sequence
>lcl|BSEQ0017206|Guanine nucleotide-binding protein G(s) subunit alpha isoforms short (GNAS)
ATGGGCTGCCTCGGGAACAGTAAGACCGAGGACCAGCGCAACGAGGAGAAGGCGCAGCGT
GAGGCCAACAAAAAGATCGAGAAGCAGCTGCAGAAGGACAAGCAGGTCTACCGGGCCACG
CACCGCCTGCTGCTGCTGGGTGCTGGAGAATCTGGTAAAAGCACCATTGTGAAGCAGATG
AGGATCCTGCATGTTAATGGGTTTAATGGAGAGGGCGGCGAAGAGGACCCGCAGGCTGCA
AGGAGCAACAGCGATGGTGAGAAGGCAACCAAAGTGCAGGACATCAAAAACAACCTGAAA
GAGGCGATTGAAACCATTGTGGCCGCCATGAGCAACCTGGTGCCCCCCGTGGAGCTGGCC
AACCCCGAGAACCAGTTCAGAGTGGACTACATCCTGAGTGTGATGAACGTGCCTGACTTT
GACTTCCCTCCCGAATTCTATGAGCATGCCAAGGCTCTGTGGGAGGATGAAGGAGTGCGT
GCCTGCTACGAACGCTCCAACGAGTACCAGCTGATTGACTGTGCCCAGTACTTCCTGGAC
AAGATCGACGTGATCAAGCAGGCTGACTATGTGCCGAGCGATCAGGACCTGCTTCGCTGC
CGTGTCCTGACTTCTGGAATCTTTGAGACCAAGTTCCAGGTGGACAAAGTCAACTTCCAC
ATGTTTGACGTGGGTGGCCAGCGCGATGAACGCCGCAAGTGGATCCAGTGCTTCAACGAT
GTGACTGCCATCATCTTCGTGGTGGCCAGCAGCAGCTACAACATGGTCATCCGGGAGGAC
AACCAGACCAACCGCCTGCAGGAGGCTCTGAACCTCTTCAAGAGCATCTGGAACAACAGA
TGGCTGCGCACCATCTCTGTGATCCTGTTCCTCAACAAGCAAGATCTGCTCGCTGAGAAA
GTCCTTGCTGGGAAATCGAAGATTGAGGACTACTTTCCAGAATTTGCTCGCTACACTACT
CCTGAGGATGCTACTCCCGAGCCCGGAGAGGACCCACGCGTGACCCGGGCCAAGTACTTC
ATTCGAGATGAGTTTCTGAGGATCAGCACTGCCAGTGGAGATGGGCGTCACTACTGCTAC
CCTCATTTCACCTGCGCTGTGGACACTGAGAACATCCGCCGTGTGTTCAACGACTGCCGT
GACATCATTCAGCGCATGCACCTTCGTCAGTACGAGCTGCTCTAA
GenBank Gene IDX04408
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:4392
Chromosome Location20
Locus20q13.3
References
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