Ras-related C3 botulinum toxin substrate 1

NameRas-related C3 botulinum toxin substrate 1
Synonyms
  • Cell migration-inducing gene 5 protein
  • p21-Rac1
  • Ras-like protein TC25
  • TC25
Gene NameRAC1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0002207|Ras-related C3 botulinum toxin substrate 1
MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAG
QEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVRHHCPNTPIILVGTKLDLR
DDKDTIEKLKEKKLTPITYPQGLAMAKEIGAVKYLECSALTQRGLKTVFDEAIRAVLCPP
PVKKRKRKCLLL
Number of residues192
Molecular Weight21449.895
Theoretical pI8.65
GO Classification
Functions
  • Rho GDP-dissociation inhibitor binding
  • enzyme binding
  • GTP binding
  • GTPase activity
  • thioesterase binding
Processes
  • response to wounding
  • regulation of cell size
  • cell motility
  • platelet activation
  • semaphorin-plexin signaling pathway
  • intracellular signal transduction
  • regulation of cell migration
  • positive regulation of Rho protein signal transduction
  • negative regulation of interleukin-23 production
  • positive regulation of neutrophil chemotaxis
  • movement of cell or subcellular component
  • actin filament polymerization
  • positive regulation of stress fiber assembly
  • anatomical structure morphogenesis
  • positive regulation of substrate adhesion-dependent cell spreading
  • positive regulation of lamellipodium assembly
  • actin cytoskeleton organization
  • regulation of small GTPase mediated signal transduction
  • cell adhesion
  • apoptotic signaling pathway
  • axon guidance
  • localization within membrane
  • T cell costimulation
  • Fc-gamma receptor signaling pathway involved in phagocytosis
  • regulation of hydrogen peroxide metabolic process
  • positive regulation of cell-substrate adhesion
  • innate immune response
  • regulation of respiratory burst
  • blood coagulation
  • ephrin receptor signaling pathway
  • positive regulation of apoptotic process
  • positive regulation of focal adhesion assembly
  • viral process
  • positive regulation of protein phosphorylation
  • cell-matrix adhesion
  • substrate adhesion-dependent cell spreading
  • Fc-epsilon receptor signaling pathway
  • lamellipodium assembly
  • regulation of defense response to virus by virus
  • neurotrophin TRK receptor signaling pathway
  • negative regulation of receptor-mediated endocytosis
  • inflammatory response
  • ruffle organization
  • vascular endothelial growth factor receptor signaling pathway
  • small GTPase mediated signal transduction
Components
  • lamellipodium
  • cytoplasmic ribonucleoprotein granule
  • cytosol
  • cytoplasm
  • focal adhesion
  • extracellular exosome
  • membrane
  • melanosome
  • plasma membrane
  • trans-Golgi network
  • endoplasmic reticulum membrane
General FunctionThioesterase binding
Specific FunctionPlasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in macrophages. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. Stimulates PKN2 kinase activity. In concert with RAB7A, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. In glioma cells, promotes cell migration and invasion. In podocytes, promotes nuclear shuttling of NR3C2; this modulation is required for a proper kidney functioning. Required for atypical chemokine receptor ACKR2-induced LIMK1-PAK1-dependent phosphorylation of cofilin (CFL1) and for up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3.Isoform B has an accelerated GEF-independent GDP/GTP exchange and an impaired GTP hydrolysis, which is restored partially by GTPase-activating proteins. It is able to bind to the GTPase-binding domain of PAK but not full-length PAK in a GTP-dependent manner, suggesting that the insertion does not completely abolish effector interaction.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID190824
UniProtKB IDP63000
UniProtKB Entry NameRAC1_HUMAN
Cellular LocationCell membrane
Gene sequence
>lcl|BSEQ0020506|Ras-related C3 botulinum toxin substrate 1 (RAC1)
ATGCAGGCCATCAAGTGTGTGGTGGTGGGAGACGGAGCTGTAGGTAAAACTTGCCTACTG
ATCAGTTACACAACCAATGCATTTCCTGGAGAATATATCCCTACTGTCTTTGACAATTAT
TCTGCCAATGTTATGGTAGATGGAAAACCGGTGAATCTGGGCTTATGGGATACAGCTGGA
CAAGAAGATTATGACAGATTACGCCCCCTATCCTATCCGCAAACAGATGTGTTCTTAATT
TGCTTTTCCCTTGTGAGTCCTGCATCATTTGAAAATGTCCGTGCAAAGTGGTATCCTGAG
GTGCGGCACCACTGTCCCAACACTCCCATCATCCTAGTGGGAACTAAACTTGATCTTAGG
GATGATAAAGACACGATCGAGAAACTGAAGGAGAAGAAGCTGACTCCCATCACCTATCCG
CAGGGTCTAGCCATGGCTAAGGAGATTGGTGCTGTAAAATACCTGGAGTGCTCGGCGCTC
ACACAGCGAGGCCTCAAGACAGTGTTTGACGAAGCGATCCGAGCAGTCCTCTGCCCGCCT
CCCGTGAAGAAGAGGAAGAGAAAATGCCTGCTGTTGTAA
GenBank Gene IDM29870
GeneCard IDNot Available
GenAtlas IDRAC1
HGNC IDHGNC:9801
Chromosome Location7
Locus7p22
References
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