Peptidyl-prolyl cis-trans isomerase FKBP1A

NamePeptidyl-prolyl cis-trans isomerase FKBP1A
Synonyms
  • 12 kDa FK506-binding protein
  • 12 kDa FKBP
  • 5.2.1.8
  • Calstabin-1
  • FK506-binding protein 1A
  • FKBP-12
  • FKBP-1A
  • FKBP1
  • FKBP12
  • Immunophilin FKBP12
  • PPIase FKBP1A
  • Rotamase
Gene NameFKBP1A
OrganismHuman
Amino acid sequence
>lcl|BSEQ0010486|Peptidyl-prolyl cis-trans isomerase FKBP1A
MGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGW
EEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLE
Number of residues108
Molecular Weight11950.665
Theoretical pI8.48
GO Classification
Functions
  • FK506 binding
  • macrolide binding
  • transforming growth factor beta receptor binding
  • peptidyl-prolyl cis-trans isomerase activity
  • type I transforming growth factor beta receptor binding
  • ion channel binding
  • activin binding
  • SMAD binding
  • signal transducer activity
Processes
  • protein refolding
  • ventricular cardiac muscle tissue morphogenesis
  • regulation of activin receptor signaling pathway
  • protein folding
  • regulation of amyloid precursor protein catabolic process
  • regulation of protein localization
  • regulation of ryanodine-sensitive calcium-release channel activity
  • SMAD protein complex assembly
  • 'de novo' protein folding
  • regulation of immune response
  • amyloid fibril formation
  • calcium ion transmembrane transport
  • chaperone-mediated protein folding
  • extracellular fibril organization
  • heart morphogenesis
  • transforming growth factor beta receptor signaling pathway
  • negative regulation of protein phosphatase type 2B activity
  • positive regulation of I-kappaB kinase/NF-kappaB signaling
  • positive regulation of protein binding
  • T cell activation
  • protein maturation by protein folding
  • positive regulation of protein ubiquitination
  • protein peptidyl-prolyl isomerization
  • heart trabecula formation
Components
  • extracellular matrix
  • terminal cisterna
  • endoplasmic reticulum membrane
  • cytosol
  • extracellular exosome
  • Z disc
  • cytoplasm
  • membrane
General FunctionType i transforming growth factor beta receptor binding
Specific FunctionKeeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruites SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID182628
UniProtKB IDP62942
UniProtKB Entry NameFKB1A_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0010487|Peptidyl-prolyl cis-trans isomerase FKBP1A (FKBP1A)
ATGGGAGTGCAGGTGGAAACCATCTCCCCAGGAGACGGGCGCACCTTCCCCAAGCGCGGC
CAGACCTGCGTGGTGCACTACACCGGGATGCTTGAAGATGGAAAGAAATTTGATTCCTCC
CGGGACAGAAACAAGCCCTTTAAGTTTATGCTAGGCAAGCAGGAGGTGATCCGAGGCTGG
GAAGAAGGGGTTGCCCAGATGAGTGTGGGTCAGAGAGCCAAACTGACTATATCTCCAGAT
TATGCCTATGGTGCCACTGGGCACCCAGGCATCATCCCACCACATGCCACTCTCGTCTTC
GATGTGGAGCTTCTAAAACTGGAATGA
GenBank Gene IDM34539
GeneCard IDNot Available
GenAtlas IDFKBP1A
HGNC IDHGNC:3711
Chromosome Location20
Locus20p13
References
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