Histone H4

NameHistone H4
Synonyms
  • H4/A
  • H4/B
  • H4/C
  • H4/D
  • H4/E
  • H4/G
  • H4/H
  • H4/I
  • H4/J
  • H4/K
  • H4/M
  • H4/N
  • H4/O
  • H4F2
  • H4FA
  • H4FB
  • H4FC
  • H4FD
  • H4FE
  • H4FG
  • H4FH
  • H4FI
  • H4FJ
  • H4FK
  • H4FM
  • H4FN
  • H4FO
  • HIST2H4
Gene NameHIST1H4A
OrganismHuman
Amino acid sequence
>lcl|BSEQ0008763|Histone H4
MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLK
VFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG
Number of residues103
Molecular Weight11367.3
Theoretical pINot Available
GO Classification
Functions
  • protein domain specific binding
  • histone demethylase activity (H4-K20 specific)
  • poly(A) RNA binding
  • DNA binding
  • histone binding
Processes
  • small GTPase mediated signal transduction
  • regulation of gene expression, epigenetic
  • gene expression
  • negative regulation of megakaryocyte differentiation
  • chromatin organization
  • gene silencing by RNA
  • double-strand break repair
  • double-strand break repair via homologous recombination
  • chromatin silencing at rDNA
  • cellular protein metabolic process
  • DNA replication-independent nucleosome assembly
  • mitotic cell cycle
  • nucleosome assembly
  • double-strand break repair via nonhomologous end joining
  • telomere maintenance
  • CENP-A containing nucleosome assembly
  • protein heterotetramerization
  • DNA replication-dependent nucleosome assembly
  • histone H4-K20 demethylation
  • DNA methylation on cytosine
  • DNA repair
  • negative regulation of gene expression, epigenetic
Components
  • nuclear chromosome, telomeric region
  • extracellular exosome
  • nucleoplasm
  • nuclear chromosome
  • nucleosome
  • membrane
  • protein complex
  • extracellular region
  • nucleus
General FunctionProtein domain specific binding
Specific FunctionCore component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Pfam Domain FunctionNot Available
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDP62805
UniProtKB Entry NameH4_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0013402|Histone H4 (HIST1H4A)
ATGTCTGGGCGAGGTAAAGGTGGCAAGGGGCTGGGTAAGGGAGGCGCCAAGCGCCACCGG
AAGGTGCTGCGGGACAATATCCAAGGCATTACAAAGCCGGCGATTCGCCGTCTCGCCCGA
CGTGGGGGCGTCAAGCGCATTTCTGGTCTCATCTACGAGGAGACCCGGGGAGTCCTCAAA
GTCTTCCTGGAGAACGTGATCCGTGACGCGGTGACTTACACGGAGCACGCCAAGCGCAAG
ACCGTCACGGCCATGGATGTGGTGTACGCGCTGAAACGCCAGGGTCGCACCCTTTATGGT
TTCGGCGGTTGA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:4781
Chromosome Location1
LocusNot Available
References
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