Beta-2-microglobulin

NameBeta-2-microglobulin
Synonyms
  • Beta-2-microglobulin form pI 5.3
Gene NameB2M
OrganismHuman
Amino acid sequence
>lcl|BSEQ0012637|Beta-2-microglobulin
MSRSVALAVLALLSLSGLEAIQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLL
KNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDM
Number of residues119
Molecular Weight13714.43
Theoretical pI6.51
GO Classification
Functions
  • glycoprotein binding
  • identical protein binding
Processes
  • antigen processing and presentation of exogenous peptide antigen via MHC class I
  • positive regulation of ferrous iron binding
  • protein refolding
  • cellular response to lipopolysaccharide
  • positive regulation of ferrous iron import into cell
  • cytokine-mediated signaling pathway
  • positive regulation of transferrin receptor binding
  • iron ion homeostasis
  • regulation of defense response to virus by virus
  • regulation of membrane depolarization
  • response to drug
  • antibacterial humoral response
  • defense response to Gram-positive bacterium
  • defense response to Gram-negative bacterium
  • T cell differentiation in thymus
  • positive regulation of receptor-mediated endocytosis
  • negative regulation of receptor binding
  • response to cadmium ion
  • antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
  • positive regulation of receptor binding
  • viral process
  • innate immune response
  • antigen processing and presentation of endogenous peptide antigen via MHC class I
  • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent
  • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
  • positive regulation of T cell cytokine production
  • antigen processing and presentation of peptide antigen via MHC class I
  • positive regulation of T cell mediated cytotoxicity
  • interferon-gamma-mediated signaling pathway
  • regulation of immune response
  • retina homeostasis
  • cellular protein metabolic process
  • cellular response to iron ion
  • positive regulation of protein binding
Components
  • membrane
  • extracellular region
  • focal adhesion
  • plasma membrane
  • extracellular space
  • MHC class I protein complex
  • Golgi apparatus
  • extracellular exosome
  • phagocytic vesicle membrane
  • early endosome membrane
  • external side of plasma membrane
  • endoplasmic reticulum lumen
  • early endosome lumen
  • HFE-transferrin receptor complex
  • ER to Golgi transport vesicle membrane
  • Golgi membrane
  • cytoplasm
General FunctionIdentical protein binding
Specific FunctionComponent of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID27763813
UniProtKB IDP61769
UniProtKB Entry NameB2MG_HUMAN
Cellular LocationSecreted
Gene sequence
>lcl|BSEQ0012638|Beta-2-microglobulin (B2M)
ATGTCTCGCTCCGTGGCCTTAGCTGTGCTCGCGCTACTCTCTCTTTCTGGCCTGGAGGCT
ATCCAGCGTACTCCAAAGATTCAGGTTTACTCACGTCATCCAGCAGAGAATGGAAAGTCA
AATTTCCTGAATTGCTATGTGTCTGGGTTTCATCCATCCGACATTGAAGTTGACTTACTG
AAGAATGGAGAGAGAATTGAAAAAGTGGAGCATTCAGACTTGTCTTTCAGCAAGGACTGG
TCTTTCTATCTCTTGTACTACACTGAATTCACCCCCACTGAAAAAGATGAGTATGCCTGC
CGTGTGAACCATGTGACTTTGTCACAGCCCAAGATAGTTAAGTGGGATCGAGACATGTAA
GenBank Gene IDAY187687
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:914
Chromosome Location15
Locus15q21-q22.2
References
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