Transforming protein RhoA

NameTransforming protein RhoA
Synonyms
  • ARH12
  • ARHA
  • h12
  • Rho cDNA clone 12
  • RHO12
Gene NameRHOA
OrganismHuman
Amino acid sequence
>lcl|BSEQ0021661|Transforming protein RhoA
MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYVADIEVDGKQVELALWDT
AGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWTPEVKHFCPNVPIILVGNKKD
LRNDEHTRRELAKMKQEPVKPEEGRDMANRIGAFGYMECSAKTKDGVREVFEMATRAALQ
ARRGKKKSGCLVL
Number of residues193
Molecular Weight21767.94
Theoretical pI5.89
GO Classification
Functions
  • GDP binding
  • myosin binding
  • GTP binding
  • GTPase activity
Processes
  • cell-matrix adhesion
  • response to ethanol
  • positive regulation of smooth muscle contraction
  • skeletal muscle tissue development
  • positive regulation of podosome assembly
  • positive regulation of cell growth
  • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
  • regulation of dendrite development
  • alpha-beta T cell lineage commitment
  • small GTPase mediated signal transduction
  • negative regulation of neuron apoptotic process
  • negative regulation of axonogenesis
  • Rho protein signal transduction
  • positive regulation of I-kappaB kinase/NF-kappaB signaling
  • forebrain radial glial cell differentiation
  • platelet activation
  • positive regulation of actin filament polymerization
  • mitotic spindle assembly
  • response to glucocorticoid
  • regulation of osteoblast proliferation
  • negative regulation of oxidative phosphorylation
  • regulation of cell migration
  • regulation of transcription from RNA polymerase II promoter
  • negative regulation of I-kappaB kinase/NF-kappaB signaling
  • ossification involved in bone maturation
  • response to glucose
  • regulation of small GTPase mediated signal transduction
  • regulation of calcium ion transport
  • positive regulation of neuron apoptotic process
  • trabecula morphogenesis
  • ephrin receptor signaling pathway
  • negative chemotaxis
  • negative regulation of reactive oxygen species biosynthetic process
  • stress-activated protein kinase signaling cascade
  • apolipoprotein A-I-mediated signaling pathway
  • stress fiber assembly
  • negative regulation of intracellular steroid hormone receptor signaling pathway
  • cleavage furrow formation
  • positive regulation of vasoconstriction
  • cerebral cortex cell migration
  • actin cytoskeleton organization
  • substantia nigra development
  • phosphatidylinositol-mediated signaling
  • androgen receptor signaling pathway
  • axon guidance
  • viral process
  • apical junction assembly
  • positive regulation of neuron differentiation
  • positive regulation of NF-kappaB import into nucleus
  • regulation of actin cytoskeleton organization
  • regulation of axonogenesis
  • positive regulation of lipase activity
  • response to mechanical stimulus
  • positive regulation of cell migration
  • skeletal muscle satellite cell migration
  • blood coagulation
  • response to amino acid
  • wound healing, spreading of cells
  • neurotrophin TRK receptor signaling pathway
  • positive regulation of cytokinesis
  • regulation of neural precursor cell proliferation
  • response to drug
  • transforming growth factor beta receptor signaling pathway
  • positive regulation of stress fiber assembly
  • response to hypoxia
  • positive regulation of translation
  • regulation of microtubule cytoskeleton organization
  • positive regulation of alpha-beta T cell differentiation
  • beta selection
  • vascular endothelial growth factor receptor signaling pathway
  • positive regulation of axonogenesis
Components
  • cleavage furrow
  • apical junction complex
  • endoplasmic reticulum membrane
  • ruffle membrane
  • endosome
  • vesicle
  • lamellipodium
  • cell junction
  • cell periphery
  • cytosol
  • axon
  • extracellular exosome
  • mitochondrion
  • focal adhesion
  • cytoskeleton
  • midbody
  • cell cortex
  • nucleus
  • plasma membrane
General FunctionMyosin binding
Specific FunctionRegulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Stimulates PKN2 kinase activity. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization (By similarity). Regulates KCNA2 potassium channel activity by reducing its location at the cell surface in response to CHRM1 activation; promotes KCNA2 endocytosis (PubMed:9635436, PubMed:19403695).(Microbial infection) Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID36030
UniProtKB IDP61586
UniProtKB Entry NameRHOA_HUMAN
Cellular LocationCell membrane
Gene sequence
>lcl|BSEQ0021662|Transforming protein RhoA (RHOA)
ATGGCTGCCATCCGGAAGAAACTGGTGATTGTTGGTGATGGAGCCTGTGGAAAGACATGC
TTGCTCATAGTCTTCAGCAAGGACCAGTTCCCAGAGGTGTATGTGCCCACAGTGTTTGAG
AACTATGTGGCAGATATCGAGGTGGATGGAAAGCAGGTAGAGTTGGCTTTGTGGGACACA
GCTGGGCAGGAAGATTATGATCGCCTGAGGCCCCTCTCCTACCCAGATACCGATGTTATA
CTGATGTGTTTTTCCATCGACAGCCCTGATAGTTTAGAAAACATCCCAGAAAAGTGGACC
CCAGAAGTCAAGCATTTCTGTCCCAACGTGCCCATCATCCTGGTTGGGAATAAGAAGGAT
CTTCGGAATGATGAGCACACAAGGCGGGAGCTAGCCAAGATGAAGCAGGAGCCGGTGAAA
CCTGAAGAAGGCAGAGATATGGCAAACAGGATTGGCGCTTTTGGGTACATGGAGTGTTCA
GCAAAGACCAAAGATGGAGTGAGAGAGGTTTTTGAAATGGCTACGAGAGCTGCTCTGCAA
GCTAGACGTGGGAAGAAAAAATCTGGGTGCCTTGTCTTGTGA
GenBank Gene IDX05026
GeneCard IDNot Available
GenAtlas IDRHOA
HGNC IDHGNC:667
Chromosome Location3
Locus3p21.3
References
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