DNA-directed RNA polymerases I, II, and III subunit RPABC2

NameDNA-directed RNA polymerases I, II, and III subunit RPABC2
Synonyms
  • DNA-directed RNA polymerase II subunit F
  • DNA-directed RNA polymerases I, II, and III 14.4 kDa polypeptide
  • POLRF
  • RNA polymerases I, II, and III subunit ABC2
  • RPABC14.4
  • RPB14.4
  • RPB6 homolog
  • RPC15
Gene NamePOLR2F
OrganismHuman
Amino acid sequence
>lcl|BSEQ0013575|DNA-directed RNA polymerases I, II, and III subunit RPABC2
MSDNEDNFDGDDFDDVEEDEGLDDLENAEEEGQENVEILPSGERPQANQKRITTPYMTKY
ERARVLGTRALQIAMCAPVMVELEGETDPLLIAMKELKARKIPIIIRRYLPDGSYEDWGV
DELIITD
Number of residues127
Molecular Weight14477.92
Theoretical pINot Available
GO Classification
Functions
  • DNA binding
  • DNA-directed RNA polymerase activity
Processes
  • RNA splicing
  • transcription initiation from RNA polymerase II promoter
  • transcription elongation from RNA polymerase II promoter
  • termination of RNA polymerase I transcription
  • innate immune response
  • termination of RNA polymerase III transcription
  • somatic stem cell population maintenance
  • transcription elongation from RNA polymerase I promoter
  • transcription-coupled nucleotide-excision repair
  • transcription elongation from RNA polymerase III promoter
  • viral process
  • transcription from RNA polymerase I promoter
  • negative regulation of gene expression, epigenetic
  • transcription from RNA polymerase III promoter
  • regulation of gene expression, epigenetic
  • DNA repair
  • transcription initiation from RNA polymerase I promoter
  • positive regulation of type I interferon production
  • 7-methylguanosine mRNA capping
  • nucleotide-excision repair
  • gene silencing by RNA
  • transcription from RNA polymerase II promoter
  • mRNA splicing, via spliceosome
  • piRNA metabolic process
  • positive regulation of viral transcription
  • gene expression
Components
  • cytosol
  • DNA-directed RNA polymerase I complex
  • nucleolus
  • DNA-directed RNA polymerase III complex
  • nucleoplasm
  • nucleus
  • DNA-directed RNA polymerase II, core complex
General FunctionDna-directed rna polymerase activity
Specific FunctionDNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II, and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2F/RPB6 is part of the clamp element and together with parts of RPB1 and RPB2 forms a pocket to which the RPB4-RPB7 subcomplex binds (By similarity).
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDP61218
UniProtKB Entry NameRPAB2_HUMAN
Cellular LocationNucleus
Gene sequenceNot Available
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:9193
Chromosome LocationNot Available
LocusNot Available
References
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  2. Pusch C, Wang Z, Roe B, Blin N: Genomic structure of the RNA polymerase II small subunit (hRPB14.4) locus (POLRF) and mapping to 22q13.1 by sequence identity. Genomics. 1996 Jun 15;34(3):440-2. 8786150
  3. Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG, Goward ME, Aguado B, Mallya M, Mokrab Y, Huckle EJ, Beare DM, Dunham I: A genome annotation-driven approach to cloning the human ORFeome. Genome Biol. 2004;5(10):R84. Epub 2004 Sep 30. 15461802
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