Actin, cytoplasmic 1

NameActin, cytoplasmic 1
Synonyms
  • Beta-actin
Gene NameACTB
OrganismHuman
Amino acid sequence
>lcl|BSEQ0021720|Actin, cytoplasmic 1
MDDDIAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQS
KRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMT
QIMFETFNTPAMYVAIQAVLSLYASGRTTGIVMDSGDGVTHTVPIYEGYALPHAILRLDL
AGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSY
ELPDGQVITIGNERFRCPEALFQPSFLGMESCGIHETTFNSIMKCDVDIRKDLYANTVLS
GGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQ
EYDESGPSIVHRKCF
Number of residues375
Molecular Weight41736.37
Theoretical pINot Available
GO Classification
Functions
  • identical protein binding
  • ATP binding
  • kinesin binding
  • structural constituent of cytoskeleton
  • Tat protein binding
  • nitric-oxide synthase binding
Processes
  • axon guidance
  • substantia nigra development
  • Fc-gamma receptor signaling pathway involved in phagocytosis
  • retina homeostasis
  • innate immune response
  • chromatin organization
  • 'de novo' posttranslational protein folding
  • adherens junction organization
  • cellular protein metabolic process
  • cell junction assembly
  • vascular endothelial growth factor receptor signaling pathway
  • blood coagulation
  • cell-cell junction organization
  • membrane organization
  • ATP-dependent chromatin remodeling
  • platelet aggregation
  • protein folding
  • small GTPase mediated signal transduction
  • movement of cell or subcellular component
  • ephrin receptor signaling pathway
Components
  • cytoplasm
  • membrane
  • protein complex
  • cortical cytoskeleton
  • ribonucleoprotein complex
  • cytoskeleton
  • plasma membrane
  • blood microparticle
  • extracellular space
  • MLL5-L complex
  • cytoplasmic ribonucleoprotein granule
  • dense body
  • NuA4 histone acetyltransferase complex
  • cytosol
  • focal adhesion
  • extracellular exosome
  • nuclear chromatin
  • myelin sheath
  • nucleoplasm
General FunctionTat protein binding
Specific FunctionActins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDP60709
UniProtKB Entry NameACTB_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0021721|Actin, cytoplasmic 1 (ACTB)
ATGGATGATGATATCGCCGCGCTCGTCGTCGACAACGGCTCCGGCATGTGCAAGGCCGGC
TTCGCGGGCGACGATGCCCCCCGGGCCGTCTTCCCCTCCATCGTGGGGCGCCCCAGGCAC
CAGGGCGTGATGGTGGGCATGGGTCAGAAGGATTCCTATGTGGGCGACGAGGCCCAGAGC
AAGAGAGGCATCCTCACCCTGAAGTACCCCATCGAGCACGGCATCGTCACCAACTGGGAC
GACATGGAGAAAATCTGGCACCACACCTTCTACAATGAGCTGCGTGTGGCTCCCGAGGAG
CACCCCGTGCTGCTGACCGAGGCCCCCCTGAACCCCAAGGCCAACCGCGAGAAGATGACC
CAGATCATGTTTGAGACCTTCAACACCCCAGCCATGTACGTTGCTATCCAGGCTGTGCTA
TCCCTGTACGCCTCTGGCCGTACCACTGGCATCGTGATGGACTCCGGTGACGGGGTCACC
CACACTGTGCCCATCTACGAGGGGTATGCCCTCCCCCATGCCATCCTGCGTCTGGACCTG
GCTGGCCGGGACCTGACTGACTACCTCATGAAGATCCTCACCGAGCGCGGCTACAGCTTC
ACCACCACGGCCGAGCGGGAAATCGTGCGTGACATTAAGGAGAAGCTGTGCTACGTCGCC
CTGGACTTCGAGCAAGAGATGGCCACGGCTGCTTCCAGCTCCTCCCTGGAGAAGAGCTAC
GAGCTGCCTGACGGCCAGGTCATCACCATTGGCAATGAGCGGTTCCGCTGCCCTGAGGCA
CTCTTCCAGCCTTCCTTCCTGGGCATGGAGTCCTGTGGCATCCACGAAACTACCTTCAAC
TCCATCATGAAGTGTGACGTGGACATCCGCAAAGACCTGTACGCCAACACAGTGCTGTCT
GGCGGCACCACCATGTACCCTGGCATTGCCGACAGGATGCAGAAGGAGATCACTGCCCTG
GCACCCAGCACAATGAAGATCAAGATCATTGCTCCTCCTGAGCGCAAGTACTCCGTGTGG
ATCGGCGGCTCCATCCTGGCCTCGCTGTCCACCTTCCAGCAGATGTGGATCAGCAAGCAG
GAGTATGACGAGTCCGGCCCCTCCATCGTCCACCGCAAATGCTTCTAG
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:132
Chromosome Location7
LocusNot Available
References
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