Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

NamePhosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
Synonyms
  • 3.1.3.16
  • MMAC1
  • Mutated in multiple advanced cancers 1
  • Phosphatase and tensin homolog
  • TEP1
Gene NamePTEN
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009278|Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
MTAIIKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSK
HKNHYKIYNLCAERHYDTAKFNCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVA
AIHCKAGKGRTGVMICAYLLHRGKFLKAQEALDFYGEVRTRDKKGVTIPSQRRYVYYYSY
LLKNHLDYRPVALLFHKMMFETIPMFSGGTCNPQFVVCQLKVKIYSSNSGPTRREDKFMY
FEFPQPLPVCGDIKVEFFHKQNKMLKKDKMFHFWVNTFFIPGPEETSEKVENGSLCDQEI
DSICSIERADNDKEYLVLTLTKNDLDKANKDKANRYFSPNFKVKLYFTKTVEEPSNPEAS
SSTSVTPDVSDNEPDHYRYSDTTDSDPENEPFDEDQHTQITKV
Number of residues403
Molecular Weight47165.92
Theoretical pINot Available
GO Classification
Functions
  • lipid binding
  • phosphatidylinositol-3-phosphatase activity
  • phosphoprotein phosphatase activity
  • protein serine/threonine phosphatase activity
  • identical protein binding
  • protein tyrosine phosphatase activity
  • magnesium ion binding
  • enzyme binding
  • protein tyrosine/serine/threonine phosphatase activity
  • anaphase-promoting complex binding
  • inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity
  • PDZ domain binding
  • phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
  • phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity
Processes
  • positive regulation of apoptotic signaling pathway
  • negative regulation of cell aging
  • response to glucose
  • angiogenesis
  • central nervous system myelin maintenance
  • platelet-derived growth factor receptor signaling pathway
  • negative regulation of epithelial cell proliferation
  • activation of APC-Cdc20 complex activity
  • response to arsenic-containing substance
  • long term synaptic depression
  • negative regulation of protein kinase B signaling
  • negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
  • Fc-epsilon receptor signaling pathway
  • male mating behavior
  • positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
  • regulation of synaptic transmission, GABAergic
  • maternal behavior
  • negative regulation of dendritic spine morphogenesis
  • response to estradiol
  • regulation of protein stability
  • cardiac muscle tissue development
  • social behavior
  • negative regulation of cell size
  • negative regulation of ribosome biogenesis
  • apoptotic process
  • negative regulation of myelination
  • dentate gyrus development
  • endothelial cell migration
  • phosphatidylinositol-mediated signaling
  • neuron-neuron synaptic transmission
  • negative regulation of synaptic vesicle clustering
  • fibroblast growth factor receptor signaling pathway
  • negative regulation of phagocytosis
  • regulation of myeloid cell apoptotic process
  • adult behavior
  • positive regulation of ERK1 and ERK2 cascade
  • negative regulation of axonogenesis
  • postsynaptic density assembly
  • heart development
  • negative regulation of protein phosphorylation
  • regulation of B cell apoptotic process
  • cell proliferation
  • central nervous system development
  • cellular response to hypoxia
  • locomotor rhythm
  • regulation of cellular component size
  • negative regulation of apoptotic process
  • peptidyl-tyrosine dephosphorylation
  • negative regulation of G1/S transition of mitotic cell cycle
  • rhythmic synaptic transmission
  • memory
  • phosphatidylinositol dephosphorylation
  • negative regulation of cell proliferation
  • inositol phosphate dephosphorylation
  • negative regulation of excitatory postsynaptic potential
  • gene expression
  • synapse assembly
  • negative regulation of cell migration
  • dendritic spine morphogenesis
  • neurotrophin TRK receptor signaling pathway
  • inositol phosphate metabolic process
  • small molecule metabolic process
  • positive regulation of excitatory postsynaptic potential
  • response to nutrient
  • regulation of cyclin-dependent protein serine/threonine kinase activity
  • positive regulation of cell proliferation
  • canonical Wnt signaling pathway
  • negative regulation of phosphatidylinositol 3-kinase signaling
  • transcription initiation from RNA polymerase II promoter
  • learning or memory
  • phospholipid metabolic process
  • regulation of neuron projection development
  • locomotory behavior
  • central nervous system neuron axonogenesis
  • long-term synaptic potentiation
  • response to ethanol
  • brain morphogenesis
  • positive regulation of sequence-specific DNA binding transcription factor activity
  • forebrain morphogenesis
  • negative regulation of focal adhesion assembly
  • response to zinc ion
  • presynaptic membrane assembly
  • prostate gland growth
  • protein stabilization
  • cell migration
  • prepulse inhibition
  • T cell receptor signaling pathway
  • regulation of axon regeneration
  • phosphatidylinositol biosynthetic process
  • epidermal growth factor receptor signaling pathway
  • multicellular organismal response to stress
  • protein dephosphorylation
  • synapse maturation
  • negative regulation of organ growth
  • response to drug
  • response to ATP
  • protein kinase B signaling
  • innate immune response
  • aging
Components
  • Schmidt-Lanterman incisure
  • plasma membrane
  • cytoplasm
  • mitochondrion
  • PML body
  • cytosol
  • extracellular region
  • cell projection
  • neuron projection
  • nucleoplasm
  • postsynaptic membrane
  • apical plasma membrane
  • nucleus
  • dendritic spine
  • myelin sheath adaxonal region
  • cytoplasmic side of plasma membrane
General FunctionProtein tyrosine/serine/threonine phosphatase activity
Specific FunctionTumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4. The lipid phosphatase activity is critical for its tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. The unphosphorylated form cooperates with AIP1 to suppress AKT1 activation. Dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation. Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. May be a negative regulator of insulin signaling and glucose metabolism in adipose tissue. The nuclear monoubiquitinated form possesses greater apoptotic potential, whereas the cytoplasmic nonubiquitinated form induces less tumor suppressive ability. In motile cells, suppresses the formation of lateral pseudopods and thereby promotes cell polarization and directed movement.Isoform alpha: Functional kinase, like isoform 1 it antagonizes the PI3K-AKT/PKB signaling pathway. Plays a role in mitochondrial energetic metabolism by promoting COX activity and ATP production, via collaboration with isoform 1 in increasing protein levels of PINK1.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDP60484
UniProtKB Entry NamePTEN_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0021732|Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN)
ATGACAGCCATCATCAAAGAGATCGTTAGCAGAAACAAAAGGAGATATCAAGAGGATGGA
TTCGACTTAGACTTGACCTATATTTATCCAAACATTATTGCTATGGGATTTCCTGCAGAA
AGACTTGAAGGCGTATACAGGAACAATATTGATGATGTAGTAAGGTTTTTGGATTCAAAG
CATAAAAACCATTACAAGATATACAATCTTTGTGCTGAAAGACATTATGACACCGCCAAA
TTTAATTGCAGAGTTGCACAATATCCTTTTGAAGACCATAACCCACCACAGCTAGAACTT
ATCAAACCCTTTTGTGAAGATCTTGACCAATGGCTAAGTGAAGATGACAATCATGTTGCA
GCAATTCACTGTAAAGCTGGAAAGGGACGAACTGGTGTAATGATATGTGCATATTTATTA
CATCGGGGCAAATTTTTAAAGGCACAAGAGGCCCTAGATTTCTATGGGGAAGTAAGGACC
AGAGACAAAAAGGGAGTAACTATTCCCAGTCAGAGGCGCTATGTGTATTATTATAGCTAC
CTGTTAAAGAATCATCTGGATTATAGACCAGTGGCACTGTTGTTTCACAAGATGATGTTT
GAAACTATTCCAATGTTCAGTGGCGGAACTTGCAATCCTCAGTTTGTGGTCTGCCAGCTA
AAGGTGAAGATATATTCCTCCAATTCAGGACCCACACGACGGGAAGACAAGTTCATGTAC
TTTGAGTTCCCTCAGCCGTTACCTGTGTGTGGTGATATCAAAGTAGAGTTCTTCCACAAA
CAGAACAAGATGCTAAAAAAGGACAAAATGTTTCACTTTTGGGTAAATACATTCTTCATA
CCAGGACCAGAGGAAACCTCAGAAAAAGTAGAAAATGGAAGTCTATGTGATCAAGAAATC
GATAGCATTTGCAGTATAGAGCGTGCAGATAATGACAAGGAATATCTAGTACTTACTTTA
ACAAAAAATGATCTTGACAAAGCAAATAAAGACAAAGCCAACCGATACTTTTCTCCAAAT
TTTAAGGTGAAGCTGTACTTCACAAAAACAGTAGAGGAGCCGTCAAATCCAGAGGCTAGC
AGTTCAACTTCTGTAACACCAGATGTTAGTGACAATGAACCTGATCATTATAGATATTCT
GACACCACTGACTCTGATCCAGAGAATGAACCTTTTGATGAAGATCAGCATACACAAATT
ACAAAAGTCTGA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:9588
Chromosome Location10
LocusNot Available
References
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