Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

NamePhosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
Synonyms
  • 3.1.3.16
  • MMAC1
  • Mutated in multiple advanced cancers 1
  • Phosphatase and tensin homolog
  • TEP1
Gene NamePTEN
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009278|Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
MTAIIKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSK
HKNHYKIYNLCAERHYDTAKFNCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVA
AIHCKAGKGRTGVMICAYLLHRGKFLKAQEALDFYGEVRTRDKKGVTIPSQRRYVYYYSY
LLKNHLDYRPVALLFHKMMFETIPMFSGGTCNPQFVVCQLKVKIYSSNSGPTRREDKFMY
FEFPQPLPVCGDIKVEFFHKQNKMLKKDKMFHFWVNTFFIPGPEETSEKVENGSLCDQEI
DSICSIERADNDKEYLVLTLTKNDLDKANKDKANRYFSPNFKVKLYFTKTVEEPSNPEAS
SSTSVTPDVSDNEPDHYRYSDTTDSDPENEPFDEDQHTQITKV
Number of residues403
Molecular Weight47165.92
Theoretical pINot Available
GO Classification
Functions
  • lipid binding
  • identical protein binding
  • phosphoprotein phosphatase activity
  • inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity
  • protein tyrosine phosphatase activity
  • phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
  • magnesium ion binding
  • phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity
  • enzyme binding
  • protein tyrosine/serine/threonine phosphatase activity
  • phosphatidylinositol-3-phosphatase activity
  • protein serine/threonine phosphatase activity
  • PDZ domain binding
  • anaphase-promoting complex binding
Processes
  • positive regulation of apoptotic signaling pathway
  • canonical Wnt signaling pathway
  • negative regulation of phosphatidylinositol 3-kinase signaling
  • angiogenesis
  • learning or memory
  • regulation of neuron projection development
  • platelet-derived growth factor receptor signaling pathway
  • Fc-epsilon receptor signaling pathway
  • central nervous system neuron axonogenesis
  • long term synaptic depression
  • long-term synaptic potentiation
  • brain morphogenesis
  • positive regulation of sequence-specific DNA binding transcription factor activity
  • forebrain morphogenesis
  • maternal behavior
  • negative regulation of focal adhesion assembly
  • presynaptic membrane assembly
  • response to estradiol
  • prostate gland growth
  • protein stabilization
  • social behavior
  • prepulse inhibition
  • regulation of axon regeneration
  • apoptotic process
  • phosphatidylinositol biosynthetic process
  • phosphatidylinositol-mediated signaling
  • multicellular organismal response to stress
  • synapse maturation
  • fibroblast growth factor receptor signaling pathway
  • response to ATP
  • positive regulation of ERK1 and ERK2 cascade
  • negative regulation of organ growth
  • heart development
  • response to glucose
  • central nervous system myelin maintenance
  • cell proliferation
  • cellular response to hypoxia
  • negative regulation of epithelial cell proliferation
  • negative regulation of cell aging
  • activation of APC-Cdc20 complex activity
  • negative regulation of apoptotic process
  • response to arsenic-containing substance
  • negative regulation of protein kinase B signaling
  • negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
  • memory
  • male mating behavior
  • negative regulation of cell proliferation
  • regulation of synaptic transmission, GABAergic
  • negative regulation of dendritic spine morphogenesis
  • gene expression
  • negative regulation of cell migration
  • positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
  • neurotrophin TRK receptor signaling pathway
  • cardiac muscle tissue development
  • negative regulation of cell size
  • negative regulation of ribosome biogenesis
  • small molecule metabolic process
  • response to nutrient
  • regulation of protein stability
  • negative regulation of myelination
  • dentate gyrus development
  • positive regulation of cell proliferation
  • endothelial cell migration
  • neuron-neuron synaptic transmission
  • negative regulation of synaptic vesicle clustering
  • transcription initiation from RNA polymerase II promoter
  • phospholipid metabolic process
  • negative regulation of phagocytosis
  • regulation of myeloid cell apoptotic process
  • locomotory behavior
  • adult behavior
  • negative regulation of axonogenesis
  • postsynaptic density assembly
  • response to ethanol
  • negative regulation of protein phosphorylation
  • regulation of B cell apoptotic process
  • central nervous system development
  • locomotor rhythm
  • regulation of cellular component size
  • response to zinc ion
  • peptidyl-tyrosine dephosphorylation
  • negative regulation of G1/S transition of mitotic cell cycle
  • rhythmic synaptic transmission
  • phosphatidylinositol dephosphorylation
  • cell migration
  • T cell receptor signaling pathway
  • protein dephosphorylation
  • inositol phosphate dephosphorylation
  • negative regulation of excitatory postsynaptic potential
  • synapse assembly
  • dendritic spine morphogenesis
  • epidermal growth factor receptor signaling pathway
  • aging
  • inositol phosphate metabolic process
  • response to drug
  • protein kinase B signaling
  • positive regulation of excitatory postsynaptic potential
  • regulation of cyclin-dependent protein serine/threonine kinase activity
  • innate immune response
Components
  • PML body
  • plasma membrane
  • cell projection
  • dendritic spine
  • myelin sheath adaxonal region
  • cytoplasmic side of plasma membrane
  • Schmidt-Lanterman incisure
  • cytoplasm
  • mitochondrion
  • cytosol
  • extracellular region
  • neuron projection
  • nucleoplasm
  • postsynaptic membrane
  • apical plasma membrane
  • nucleus
General FunctionProtein tyrosine/serine/threonine phosphatase activity
Specific FunctionTumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4. The lipid phosphatase activity is critical for its tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. The unphosphorylated form cooperates with AIP1 to suppress AKT1 activation. Dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation. Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. May be a negative regulator of insulin signaling and glucose metabolism in adipose tissue. The nuclear monoubiquitinated form possesses greater apoptotic potential, whereas the cytoplasmic nonubiquitinated form induces less tumor suppressive ability. In motile cells, suppresses the formation of lateral pseudopods and thereby promotes cell polarization and directed movement.Isoform alpha: Functional kinase, like isoform 1 it antagonizes the PI3K-AKT/PKB signaling pathway. Plays a role in mitochondrial energetic metabolism by promoting COX activity and ATP production, via collaboration with isoform 1 in increasing protein levels of PINK1.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDP60484
UniProtKB Entry NamePTEN_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0021732|Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN)
ATGACAGCCATCATCAAAGAGATCGTTAGCAGAAACAAAAGGAGATATCAAGAGGATGGA
TTCGACTTAGACTTGACCTATATTTATCCAAACATTATTGCTATGGGATTTCCTGCAGAA
AGACTTGAAGGCGTATACAGGAACAATATTGATGATGTAGTAAGGTTTTTGGATTCAAAG
CATAAAAACCATTACAAGATATACAATCTTTGTGCTGAAAGACATTATGACACCGCCAAA
TTTAATTGCAGAGTTGCACAATATCCTTTTGAAGACCATAACCCACCACAGCTAGAACTT
ATCAAACCCTTTTGTGAAGATCTTGACCAATGGCTAAGTGAAGATGACAATCATGTTGCA
GCAATTCACTGTAAAGCTGGAAAGGGACGAACTGGTGTAATGATATGTGCATATTTATTA
CATCGGGGCAAATTTTTAAAGGCACAAGAGGCCCTAGATTTCTATGGGGAAGTAAGGACC
AGAGACAAAAAGGGAGTAACTATTCCCAGTCAGAGGCGCTATGTGTATTATTATAGCTAC
CTGTTAAAGAATCATCTGGATTATAGACCAGTGGCACTGTTGTTTCACAAGATGATGTTT
GAAACTATTCCAATGTTCAGTGGCGGAACTTGCAATCCTCAGTTTGTGGTCTGCCAGCTA
AAGGTGAAGATATATTCCTCCAATTCAGGACCCACACGACGGGAAGACAAGTTCATGTAC
TTTGAGTTCCCTCAGCCGTTACCTGTGTGTGGTGATATCAAAGTAGAGTTCTTCCACAAA
CAGAACAAGATGCTAAAAAAGGACAAAATGTTTCACTTTTGGGTAAATACATTCTTCATA
CCAGGACCAGAGGAAACCTCAGAAAAAGTAGAAAATGGAAGTCTATGTGATCAAGAAATC
GATAGCATTTGCAGTATAGAGCGTGCAGATAATGACAAGGAATATCTAGTACTTACTTTA
ACAAAAAATGATCTTGACAAAGCAAATAAAGACAAAGCCAACCGATACTTTTCTCCAAAT
TTTAAGGTGAAGCTGTACTTCACAAAAACAGTAGAGGAGCCGTCAAATCCAGAGGCTAGC
AGTTCAACTTCTGTAACACCAGATGTTAGTGACAATGAACCTGATCATTATAGATATTCT
GACACCACTGACTCTGATCCAGAGAATGAACCTTTTGATGAAGATCAGCATACACAAATT
ACAAAAGTCTGA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:9588
Chromosome Location10
LocusNot Available
References
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