Potassium-transporting ATPase alpha chain 2

NamePotassium-transporting ATPase alpha chain 2
Synonyms
  • 3.6.3.10
  • ATP1AL1
  • Non-gastric H(+)/K(+) ATPase subunit alpha
  • Proton pump
Gene NameATP12A
OrganismHuman
Amino acid sequence
>lcl|BSEQ0037108|Potassium-transporting ATPase alpha chain 2
MHQKTPEIYSVELSGTKDIVKTDKGDGKEKYRGLKNNCLELKKKNHKEEFQKELHLDDHK
LSNRELEEKYGTDIIMGLSSTRAAELLARDGPNSLTPPKQTPEIVKFLKQMVGGFSILLW
VGAFLCWIAYGIQYSSDKSASLNNVYLGCVLGLVVILTGIFAYYQEAKSTNIMSSFNKMI
PQQALVIRDSEKKTIPSEQLVVGDIVEVKGGDQIPADIRVLSSQGCRVDNSSLTGESEPQ
PRSSEFTHENPLETKNICFYSTTCLEGTVTGMVINTGDRTIIGHIASLASGVGNEKTPIA
IEIEHFVHIVAGVAVSIGILFFIIAVSLKYQVLDSIIFLIGIIVANVPEGLLATVTVTLS
LTAKRMAKKNCLVKNLEAVETLGSTSIICSDKTGTLTQNRMTVAHLWFDNQIFVADTSED
HSNQVFDQSSRTWASLSKIITLCNRAEFKPGQENVPIMKKAVIGDASETALLKFSEVILG
DVMEIRKRNRKVAEIPFNSTNKFQLSIHEMDDPHGKRFLMVMKGAPERILEKCSTIMING
EEHPLDKSTAKTFHTAYMELGGLGERVLGFCHLYLPADEFPETYSFDIDAMNFPTSNLCF
VGLLSMIDPPRSTVPDAVTKCRSAGIKVIMVTGDHPITAKAIAKSVGIISANSETVEDIA
HRLNIAVEQVNKRDAKAAVVTGMELKDMSSEQLDEILANYQEIVFARTSPQQKLIIVEGC
QRQDAVVAVTGDGVNDSPALKKADIGIAMGIAGSDAAKNAADMVLLDDNFASIVTGVEEG
RLIFDNLKKTIAYSLTKNIAELCPFLIYIIVGLPLPIGTITILFIDLGTDIIPSIALAYE
KAESDIMNRKPRHKNKDRLVNQPLAVYSYLHIGLMQALGAFLVYFTVYAQEGFLPRTLIN
LRVEWEKDYVNDLKDSYGQEWTRYQREYLEWTGYTAFFVGILVQQIADLIIRKTRRNSIF
QQGLFRNKVIWVGITSQIIIGLILSYGLGSVTALSFTMLRAQYWFVAVPHAILIWVYDEV
RKLFIRLYPGSWWDKNMYY
Number of residues1039
Molecular Weight115509.45
Theoretical pI6.52
GO Classification
Functions
  • metal ion binding
  • sodium
  • hydrogen
  • ATP binding
Processes
  • regulation of pH
  • response to metal ion
  • transmembrane transport
  • ion transmembrane transport
  • potassium ion import
  • establishment or maintenance of transmembrane electrochemical gradient
  • sodium ion export from cell
  • cellular potassium ion homeostasis
  • ATP hydrolysis coupled proton transport
  • cellular sodium ion homeostasis
  • response to organic cyclic compound
Components
  • hydrogen
  • intracellular membrane-bounded organelle
  • basolateral plasma membrane
  • apical plasma membrane
  • plasma membrane
General FunctionSodium:potassium-exchanging atpase activity
Specific FunctionCatalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for potassium absorption in various tissues.
Pfam Domain Function
Transmembrane Regions103-123 147-167 304-323 336-353 788-807 818-838 859-881 934-953 968-986 1002-1022
GenBank Protein ID404017
UniProtKB IDP54707
UniProtKB Entry NameAT12A_HUMAN
Cellular LocationMembrane
Gene sequence
>lcl|BSEQ0010684|Potassium-transporting ATPase alpha chain 2 (ATP12A)
ATGCACCAGAAAACCCCAGAAATTTACTCCGTGGAGCTCAGCGGAACTAAGGACATCGTG
AAAACAGACAAGGGGGATGGCAAGGAGAAGTATAGGGGTCTGAAGAACAACTGCCTGGAA
CTCAAAAAGAAAAATCACAAAGAGGAGTTTCAGAAAGAACTCCATCTGGATGACCACAAA
CTCAGCAATAGGGAATTGGAAGAGAAATATGGCACAGACATCATTATGGGTCTCTCCAGC
ACCAGAGCTGCCGAGCTCCTGGCCCGGGATGGGCCCAACTCCCTCACCCCTCCCAAGCAG
ACGCCTGAGATCGTCAAGTTCCTCAAGCAGATGGTGGGGGGGTTCTCTATCCTCCTGTGG
GTGGGCGCCTTTCTCTGTTGGATTGCATATGGGATTCAGTACTCCAGCGACAAGTCTGCA
TCCCTGAACAACGTGTACTTGGGCTGTGTGCTTGGTCTGGTGGTCATTTTAACGGGGATC
TTTGCTTATTACCAAGAGGCAAAAAGCACCAACATCATGTCCAGCTTCAATAAGATGATC
CCTCAGCAAGCTCTCGTCATCCGAGATTCCGAGAAGAAGACCATCCCTTCAGAGCAGCTG
GTGGTGGGGGACATTGTGGAGGTCAAAGGAGGAGACCAGATCCCTGCAGACATCAGGGTG
CTGTCTTCTCAGGGGTGTCGGGTGGATAACTCATCTCTCACGGGGGAGTCTGAGCCCCAG
CCCCGCTCCTCTGAGTTTACCCATGAAAACCCCCTGGAAACAAAGAACATCTGCTTCTAT
TCCACAACGTGTCTGGAAGCATCTACTTCCCCTGTAGGCACTGTCACCGGCATGGTTATC
AACACGGGTGACCGCACCATCATTGGCCATATTGCCTCATTGGCCTCAGGAGTTGGAAAT
GAGAAGACGCCCATTGCCATTGAGATCGAGCACTTTGTTCACATTGTGGCAGGAGTGGCT
GTCTCCATCGGCATCCTTTTCTTCATCATCGCTGTGTCCCTGAAGTATCAAGTCCTGGAC
TCCATCATCTTCCTCATTGGCATCATTGTGGCCAATGTGCCCGAGGGCCTCCTGGCCACT
GTCACTGTGACCCTGTCGCTGACAGCAAAACGGATGGCCAAGAAGAACTGCCTGGTGAAG
AACCTGGAGGCTGTGGAGACCCTCGGCTCCACCTCCATCATCTGCTCGGACAAGACTGGG
ACACTGACCCAGAACAGGATGACAGTGGCCCATCTGTGGTTCGACAATCAGATCTTTGTG
GCTGACACCAGTGAGGACCATTCAAACCAAGTCTTTGACCAAAGCTCTAGGACTTGGGCC
TCCTTATCCAAGATAATAACATTGTGTAACCGAGCAGAGTTCAAGCCAGGACAGGAAAAT
GTCCCCATCATGAAGAAAGCTGTGATTGGAGATGCCTCAGAAACTGCTCTTTTAAAATTC
TCAGAGGTCATTTTGGGTGATGTGATGGAAATTAGAAAAAGAAACCGCAAAGTAGCTGAA
ATCCCTTTTAACTCTACTAATAAATTTCAGCTCTCCATCCACGAGATGGATGACCCCCAC
GGCAAGCGCTTCCTCATGGTGATGAAGGGGGCCCCTGAGCGCATCCTAGAGAAATGCAGC
ACCATCATGATCAACGGCGAGGAGCACCCACTGGACAAGAGCACTGCCAAGACCTTCCAC
ACAGCCTACATGGAGCTGGGCGGGTTGGGCGAGCGTGTGCTGGGTTTCTGTCATCTCTAC
CTGCCAGCAGACGAGTTTCCAGAAACCTACTCATTTGACATAGACGCTATGAACTTTCCG
ACCTCCAACCTCTGTTTTGTGGGACTCTTGTCAATGATCGATCCCCCTCGGTCCACCGTG
CCAGATGCAGTCACCAAATGCCGGAGTGCAGGGATCAAGGTTATTATGGTTACTGGTGAT
CATCCCATCACAGCCAAAGCTATTGCCAAGAGTGTGGGGATCATTTCAGCCAACAGTGAA
ACAGTGGAAGACATTGCACATCGCCTCAACATTGCTGTGGAGCAAGTTAACAAACGGGAT
GCCAAGGCCGCTGTGGTGACTGGCATGGAGCTGAAGGACATGAGCTCAGAACAGCTGGAT
GAGATCTTAGCCAACTACCAGGAGATTGTCTTTGCCCGGACATCCCCCCAGCAGAAGCTG
ATCATTGTGGAGGGCTGTCAGAGGCAGGATGCTGTTGTTGCTGTGACCGGGGATGGAGTT
AATGACTCTCCGGCTCTAAAGAAGGCAGACATTGGGATTGCCATGGGGATAGCAGGTTCT
GATGCAGCCAAAAATGCAGCCGACATGGTCTTGCTGGACGACAACTTCGCATCCATCGTC
ACAGGGGTGGAGGAAGGTCGCCTGATCTTTGACAACCTCAAGAAGACTATTGCTTATTCC
CTGACCAAGAACATTGCCGAGCTGTGCCCCTTTCTGATCTACATCATTGTCGGGCTCCCC
CTGCCCATTGGCACCATCACCATTCTGTTCATTGACTTGGGGACAGACATTATCCCCTCC
ATTGCCTTGGCGTACGAGAAAGCTGAAAGTGACATCATGAACAGGAAGCCTCGCCACAAG
AATAAGGACAGGCTGGTGAACCAGCCGCTCGCTGTGTACTCATACCTGCACATTGGCCTC
ATGCAAGCCCTGGGAGCTTTCCTTGTGTATTTCACCGTCTATGCACAAGAGGGCTTTCTG
CCCCGCACTCTCATTAACCTGCGGGTAGAATGGGAGAAGGACTACGTGAATGACTTGAAA
GACAGCTATGGGCAGGAATGGACAAGGTACCAGAGGGAATACCTAGAATGGACGGGCTAC
ACGGCTTTCTTTGTTGGCATCCTAGTCCAGCAAATAGCAGATCTGATCATCAGGAAAACC
CGGAGGAATTCCATCTTCCAGCAGGGTCTCTTCAGAAATAAAGTCATCTGGGTGGGGATC
ACCTCACAGATCATCATTGGTCTGATCCTCTCCTATGGCCTCGGAAGTGTCACAGCCTTG
AGTTTCACCATGCTTAGGGCTCAGTACTGGTTTGTGGCTGTGCCGCACGCCATCCTGATC
TGGGTGTATGATGAGGTGCGGAAGCTCTTCATCAGGCTCTACCCTGGAAGCTGGTGGGAT
AAGAACATGTATTATTAA
GenBank Gene IDU02076
GeneCard IDNot Available
GenAtlas IDATP12A
HGNC IDHGNC:13816
Chromosome Location13
Locus13q12.12|13q12.1-q12.3
References
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