Serine/threonine-protein phosphatase 5

NameSerine/threonine-protein phosphatase 5
Synonyms
  • 3.1.3.16
  • PP-T
  • PP5
  • PPP5
  • PPT
  • Protein phosphatase T
Gene NamePPP5C
OrganismHuman
Amino acid sequence
>lcl|BSEQ0012211|Serine/threonine-protein phosphatase 5
MAMAEGERTECAEPPRDEPPADGALKRAEELKTQANDYFKAKDYENAIKFYSQAIELNPS
NAIYYGNRSLAYLRTECYGYALGDATRAIELDKKYIKGYYRRAASNMALGKFRAALRDYE
TVVKVKPHDKDAKMKYQECNKIVKQKAFERAIAGDEHKRSVVDSLDIESMTIEDEYSGPK
LEDGKVTISFMKELMQWYKDQKKLHRKCAYQILVQVKEVLSKLSTLVETTLKETEKITVC
GDTHGQFYDLLNIFELNGLPSETNPYIFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLL
RGNHETDNMNQIYGFEGEVKAKYTAQMYELFSEVFEWLPLAQCINGKVLIMHGGLFSEDG
VTLDDIRKIERNRQPPDSGPMCDLLWSDPQPQNGRSISKRGVSCQFGPDVTKAFLEENNL
DYIIRSHEVKAEGYEVAHGGRCVTVFSAPNYCDQMGNKASYIHLQGSDLRPQFHQFTAVP
HPNVKPMAYANTLLQLGMM
Number of residues499
Molecular Weight56878.22
Theoretical pI6.21
GO Classification
Functions
  • RNA binding
  • lipid binding
  • protein serine/threonine phosphatase activity
  • phosphoprotein phosphatase activity
  • metal ion binding
  • ADP binding
  • signal transducer activity
  • identical protein binding
  • ATP binding
Processes
  • positive regulation of I-kappaB kinase/NF-kappaB signaling
  • activation of MAPKK activity
  • fibroblast growth factor receptor signaling pathway
  • DNA repair
  • negative regulation of protein phosphorylation
  • negative regulation of neuron death
  • insulin receptor signaling pathway
  • MAPK cascade
  • cellular response to cadmium ion
  • neurotrophin TRK receptor signaling pathway
  • small GTPase mediated signal transduction
  • Ras protein signal transduction
  • histone dephosphorylation
  • vascular endothelial growth factor receptor signaling pathway
  • positive regulation of glucocorticoid receptor signaling pathway
  • axon guidance
  • transcription, DNA-templated
  • double-strand break repair
  • protein heterooligomerization
  • epidermal growth factor receptor signaling pathway
  • protein dephosphorylation
  • innate immune response
  • cellular response to hydrogen peroxide
  • mitotic nuclear division
  • Fc-epsilon receptor signaling pathway
  • response to morphine
  • response to lead ion
Components
  • intracellular membrane-bounded organelle
  • nucleus
  • cell periphery
  • proximal dendrite
  • cytosol
  • nucleoplasm
  • perikaryon
  • cytoplasm
  • membrane
  • protein complex
General FunctionSignal transducer activity
Specific FunctionSerine/threonine-protein phosphatase that dephosphorylates a myriad of proteins involved in different signaling pathways including the kinases CSNK1E, ASK1/MAP3K5, PRKDC and RAF1, the nuclear receptors NR3C1, PPARG, ESR1 and ESR2, SMAD proteins and TAU/MAPT. Implicated in wide ranging cellular processes, including apoptosis, differentiation, DNA damage response, cell survival, regulation of ion channels or circadian rhythms, in response to steroid and thyroid hormones, calcium, fatty acids, TGF-beta as well as oxidative and genotoxic stresses. Participates in the control of DNA damage response mechanisms such as checkpoint activation and DNA damage repair through, for instance, the regulation ATM/ATR-signaling and dephosphorylation of PRKDC and TP53BP1. Inhibits ASK1/MAP3K5-mediated apoptosis induced by oxidative stress. Plays a positive role in adipogenesis, mainly through the dephosphorylation and activation of PPARG transactivation function. Also dephosphorylates and inhibits the anti-adipogenic effect of NR3C1. Regulates the circadian rhythms, through the dephosphorylation and activation of CSNK1E. May modulate TGF-beta signaling pathway by the regulation of SMAD3 phosphorylation and protein expression levels. Dephosphorylates and may play a role in the regulation of TAU/MAPT. Through their dephosphorylation, may play a role in the regulation of ions channels such as KCNH2.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDP53041
UniProtKB Entry NamePPP5_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0006165|1483 bp
CGAGAGGACTGAGTGTGCTGAGCCCCCCCGGGACGAACCCCCGGCTGATGGAGCTCTGAA
GCGGGCAGAGGAGCTCAAGACTCAGGCCAATGACTACTTCAAAGCCAAGGACTACGAGAA
CGCCATCAAGTTCTACAGCCAGGCCATCGAGCTGAACCCCAGCAATGCCATCTACTATGG
CAACCGCAGCCTGGCCTACCTGCGCACTGAGTGCTATGGCTACGCGCTGGGAGACGCCAC
GCGGGCCATTGAGCTGGACAAGAAGTACATCAAGGGTTATTACCGCCGGGCTGCCAGCAA
CATGGCACTGGGCAAGTTCCGGGCCGCGCTGCGAGACTACGAGACGGTGGTCAAGGTGAA
GCCCCATGACAAGGATGCCAAAATGAAATACCAGGAGTGCAACAAGATCGTGAAGCAGAA
GGCCTTTGAGCGGGCCATCGCGGGCGACGAGCACAAGCGCTCCGTGGTGGACTCGCTGGA
CATCGAGAGCATGACCATTGAGGATGAGTACAGCGGACCCAAGCTTGAAGACGGCAAAGT
GACAATCAGTTTCATGAAGGAGCTCATGCAGTGGTACAAGGACCAGAAGAAACTGCACCG
GAAATGTGCCTACCAGATTCTGGTACAGGTCAAAGAGGTCCTCTCCAAGCTGAGCACGCT
CGTGGAAACCACACTCAAAGAGACAGAGAAGATTACAGTATGTGGGGACACCCATGGCCA
GTTCTATGACCTCCTCAACATATTCGAGCTCAACGGTTTACCCTCGGAGACCAACCCCTA
TATATTTAATGGTGACTTTGTGGACCGAGGCTCCTTCTCTGTAGAAGTGATCCTCACCCT
TTTCGGCTTCAAGCTCCTGTACCCAGATCACTTTCACCTCCTTCGAGGCAACCACGAGAC
AGACAACATGAACCAGATCTACGGTTTCGAGGGTGAGGTGAAGGCCAAGTACACAGCCCA
GATGTACGAGCTCTTTAGCGAGGTGTTCGAGTGGCTCCCGTTGGCCCAGTGCATCAACGG
CAAAGTGCTGATCATGCACGGAGGCCTGTTCAGTGAAGACGGTGTCACCCTGGATGACAT
CCGGAAAATTGAGCGGAATCGACAACCCCCAGATTCAGGGCCCATGTGTGACCTGCTCTG
GTCAGATCCACAGCCACAGAACGGGCGCTCGATCAGCAAGCGGGGCGTGAGCTGTCAGTT
TGGGCCTGACGTCACCAAGGCCTTCTTGGAAGAGAACAACCTGGACTATATCATCCGCAG
CCACGAAGTCAAGGCCGAGGGCTACGAGGTGGCTCACGGAGGCCGCTGTGTCACCGTCTT
CTCTGCCCCCAACTACTGCGACCAGATGGGGAACAAAGCCTCCTACATCCACCTCCAGGG
CTCTGACCTACGGCCTCAGTTCCACCAGTTCACAGCAGTGCCTCATCCCAACGTCAAGCC
CATGGCCTATGCCAACACGCTGCTGCAGCTAGGAATGATGTGA
GenBank Gene IDX89416
GeneCard IDNot Available
GenAtlas IDPPP5C
HGNC IDHGNC:9322
Chromosome LocationNot Available
Locus19q13.3
References
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