Aldo-keto reductase family 1 member C2

NameAldo-keto reductase family 1 member C2
Synonyms
  • 1.-.-.-
  • 3-alpha-HSD3
  • Chlordecone reductase homolog HAKRD
  • DD-2
  • DD/BABP
  • DD2
  • DDH2
  • Dihydrodiol dehydrogenase 2
  • Dihydrodiol dehydrogenase/bile acid-binding protein
  • Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
  • Type III 3-alpha-hydroxysteroid dehydrogenase
Gene NameAKR1C2
OrganismHuman
Amino acid sequence
>lcl|BSEQ0001240|Aldo-keto reductase family 1 member C2
MDSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQ
VGLAIRSKIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPV
SVKPGEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKP
GLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPV
LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN
RNVRYLTLDIFAGPPNYPFSDEY
Number of residues323
Molecular Weight36734.97
Theoretical pI7.55
GO Classification
Functions
  • bile acid binding
  • oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
  • alditol
  • carboxylic acid binding
  • ketosteroid monooxygenase activity
  • phenanthrene 9,10-monooxygenase activity
  • trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
Processes
  • daunorubicin metabolic process
  • digestion
  • doxorubicin metabolic process
  • epithelial cell differentiation
  • progesterone metabolic process
  • oxidation-reduction process
  • steroid metabolic process
  • G-protein coupled receptor signaling pathway
  • positive regulation of cell proliferation
  • positive regulation of protein kinase B signaling
  • cellular response to prostaglandin D stimulus
  • prostaglandin metabolic process
  • cellular response to jasmonic acid stimulus
Components
  • cytoplasm
General FunctionTrans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
Specific FunctionWorks in concert with the 5-alpha/5-beta-steroid reductases to convert steroid hormones into the 3-alpha/5-alpha and 3-alpha/5-beta-tetrahydrosteroids. Catalyzes the inactivation of the most potent androgen 5-alpha-dihydrotestosterone (5-alpha-DHT) to 5-alpha-androstane-3-alpha,17-beta-diol (3-alpha-diol). Has a high bile-binding ability.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID531160
UniProtKB IDP52895
UniProtKB Entry NameAK1C2_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0010433|Aldo-keto reductase family 1 member C2 (AKR1C2)
ATGGATTCGAAATACCAGTGTGTGAAGCTGAATGATGGTCACTTCATGCCTGTCCTGGGA
TTTGGCACCTATGCGCCTGCAGAGGTTCCTAAAAGTAAAGCTCTAGAGGCCGTCAAATTG
GCAATAGAAGCCGGGTTCCACCATATTGATTCTGCACATGTTTACAATAATGAGGAGCAG
GTTGGACTGGCCATCCGAAGCAAGATTGCAGATGGCAGTGTGAAGAGAGAAGACATATTC
TACACTTCAAAGCTTTGGAGCAATTCCCATCGACCAGAGTTGGTCCGACCAGCCTTGGAA
AGGTCACTGAAAAATCTTCAATTGGACTATGTTGACCTCTATCTTATTCATTTTCCAGTG
TCTGTAAAGGAGGACATAGGGATTTTAACATGGAAGAAGAGCCCTAAACATAACTCCTAA
GenBank Gene IDU05598
GeneCard IDNot Available
GenAtlas IDAKR1C2
HGNC IDHGNC:385
Chromosome Location10
Locus10p15-p14
References
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  2. Ciaccio PJ, Tew KD: cDNA and deduced amino acid sequences of a human colon dihydrodiol dehydrogenase. Biochim Biophys Acta. 1994 Jun 28;1186(1-2):129-32. 8011662
  3. Qin KN, Khanna M, Cheng KC: Structure of a gene coding for human dihydrodiol dehydrogenase/bile acid-binding protein. Gene. 1994 Nov 18;149(2):357-61. 7959017
  4. Dufort I, Soucy P, Labrie F, Luu-The V: Molecular cloning of human type 3 3 alpha-hydroxysteroid dehydrogenase that differs from 20 alpha-hydroxysteroid dehydrogenase by seven amino acids. Biochem Biophys Res Commun. 1996 Nov 12;228(2):474-9. 8920937
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