NameSpermine synthase
Synonyms
  • 2.5.1.22
  • Spermidine aminopropyltransferase
  • SPMSY
Gene NameSMS
OrganismHuman
Amino acid sequence
>lcl|BSEQ0001919|Spermine synthase
MAAARHSTLDFMLGAKADGETILKGLQSIFQEQGMAESVHTWQDHGYLATYTNKNGSFAN
LRIYPHGLVLLDLQSYDGDAQGKEEIDSILNKVEERMKELSQDSTGRVKRLPPIVRGGAI
DRYWPTADGRLVEYDIDEVVYDEDSPYQNIKILHSKQFGNILILSGDVNLAESDLAYTRA
IMGSGKEDYTGKDVLILGGGDGGILCEIVKLKPKMVTMVEIDQMVIDGCKKYMRKTCGDV
LDNLKGDCYQVLIEDCIPVLKRYAKEGREFDYVINDLTAVPISTSPEEDSTWEFLRLILD
LSMKVLKQDGKYFTQGNCVNLTEALSLYEEQLGRLYCPVEFSKEIVCVPSYLELWVFYTV
WKKAKP
Number of residues366
Molecular Weight41267.855
Theoretical pI4.62
GO Classification
Functions
  • spermine synthase activity
Processes
  • polyamine metabolic process
  • spermine biosynthetic process
  • methionine metabolic process
  • cellular nitrogen compound metabolic process
  • small molecule metabolic process
Components
  • cytosol
  • extracellular exosome
General FunctionSpermine synthase activity
Specific FunctionCatalyzes the production of spermine from spermidine and decarboxylated S-adenosylmethionine (dcSAM).
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID791051
UniProtKB IDP52788
UniProtKB Entry NameSPSY_HUMAN
Cellular LocationNot Available
Gene sequence
>lcl|BSEQ0010676|Spermine synthase (SMS)
ATGGCAGCAGCACGGCACAGCACGCTCGACTTCATGCTCGGCGCCAAAGCTGATGGTGAG
ACCATTCTAAAAGGCCTCCAGTCCATTTTCCAGGAGCAGGGGATGGCGGAGTCGGTGCAC
ACCTGGCAGGACCATGGCTATTTAGCAACCTACACAAACAAGAACGGCAGATTACCACCC
ATAGTGCGAGGAGGAGCCATCGACAGATACTGGCCCACCGCCGACGGGCGCCTGGTTGAA
TATGACATAGATGAAGTGGTATATGACGAAGATTCACCTTATCAAAATATAAAAATTCTA
CACTCGAAGCAGTTTGGAAATATTCTCATCCTTAGTGGGGATGTTAATTTGGCAGAGAGT
GATTTGGCATATACCCGGGCCATCATGGGCAGTGGCAAAGAAGATTACACTGGCAAAGAT
GTACTCATTCTGGGAGGTGGAGACGGAGGCATATTGTGTGAAATAGTCAAACTAAAACCA
AAGATGGTCACTATGGTAGAGATTGACCAAATGGTGATTGATGGGTGTAAGAAATACATG
CGAAAAACGTGTGGCGATGTCTTAGACAATCTTAAAGGAGACTGCTATCAGGTTCTAATA
GAAGACTGTATCCCGGTACTGAAGAGGTACGCCAAAGAAGGGAGAGAATTTGATTATGTG
ATTAATGATTTGACAGCTGTTCCAATCTCCACGTCTCCAGAAGAAGATTCCACATGGGAG
TTTCTCAGACTGATTCTTGACCTCTCAATGAAAGTGTTGAAACAGGATGGGAAATATTTT
ACACAGGGGAACTGTGTCAATCTGACAGAAGCACTGTCGCTCTATGAAGAACAGCTGGGG
CGCCTGTATTGTCCTGTGGAATTTTCAAAGGAGATCGTCTGTGTCCCTTCATACTTGGAA
TTGTGGGTATTTTACACTGTTTGGAAGAAAGCTAAACCCTGA
GenBank Gene IDZ49099
GeneCard IDNot Available
GenAtlas IDSMS
HGNC IDHGNC:11123
Chromosome LocationX
LocusXp22.1
References
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