Dual specificity mitogen-activated protein kinase kinase 6

NameDual specificity mitogen-activated protein kinase kinase 6
Synonyms
  • 2.7.12.2
  • MAP kinase kinase 6
  • MAPK/ERK kinase 6
  • MEK 6
  • MEK6
  • MKK6
  • PRKMK6
  • SAPK kinase 3
  • SAPKK-3
  • SAPKK3
  • SKK3
  • Stress-activated protein kinase kinase 3
Gene NameMAP2K6
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009091|Dual specificity mitogen-activated protein kinase kinase 6
MSQSKGKKRNPGLKIPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELG
RGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALF
REGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDV
KPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDI
WSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSK
ERPTYPELMQHPFFTLHESKGTDVASFVKLILGD
Number of residues334
Molecular Weight37492.055
Theoretical pINot Available
GO Classification
Functions
  • protein kinase binding
  • ATP binding
  • protein serine/threonine kinase activity
  • MAP kinase kinase activity
  • protein tyrosine kinase activity
Processes
  • signal transduction by protein phosphorylation
  • stress-activated MAPK cascade
  • DNA damage induced protein phosphorylation
  • innate immune response
  • stress-activated protein kinase signaling cascade
  • toll-like receptor 10 signaling pathway
  • muscle cell differentiation
  • cellular response to sorbitol
  • toll-like receptor 2 signaling pathway
  • positive regulation of apoptotic process
  • toll-like receptor 3 signaling pathway
  • positive regulation of muscle cell differentiation
  • toll-like receptor 4 signaling pathway
  • regulation of transcription, DNA-templated
  • toll-like receptor 5 signaling pathway
  • apoptotic process
  • signal transduction
  • toll-like receptor 9 signaling pathway
  • toll-like receptor signaling pathway
  • cardiac muscle contraction
  • toll-like receptor TLR1
  • transcription, DNA-templated
  • toll-like receptor TLR6
  • activation of MAPK activity
  • response to drug
  • TRIF-dependent toll-like receptor signaling pathway
  • positive regulation of prostaglandin secretion
  • cell cycle arrest
  • positive regulation of nitric-oxide synthase biosynthetic process
  • ovulation cycle process
  • regulation of apoptotic process
  • nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
  • nucleotide-binding oligomerization domain containing signaling pathway
  • response to ischemia
  • regulation of mitotic cell cycle
  • MyD88-dependent toll-like receptor signaling pathway
  • MyD88-independent toll-like receptor signaling pathway
Components
  • cytoplasm
  • cytoskeleton
  • cytosol
  • nucleoplasm
General FunctionProtein tyrosine kinase activity
Specific FunctionDual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. With MAP3K3/MKK3, catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinases p38 MAPK11, MAPK12, MAPK13 and MAPK14 and plays an important role in the regulation of cellular responses to cytokines and all kinds of stresses. Especially, MAP2K3/MKK3 and MAP2K6/MKK6 are both essential for the activation of MAPK11 and MAPK13 induced by environmental stress, whereas MAP2K6/MKK6 is the major MAPK11 activator in response to TNF. MAP2K6/MKK6 also phosphorylates and activates PAK6. The p38 MAP kinase signal transduction pathway leads to direct activation of transcription factors. Nuclear targets of p38 MAP kinase include the transcription factors ATF2 and ELK1. Within the p38 MAPK signal transduction pathway, MAP3K6/MKK6 mediates phosphorylation of STAT4 through MAPK14 activation, and is therefore required for STAT4 activation and STAT4-regulated gene expression in response to IL-12 stimulation. The pathway is also crucial for IL-6-induced SOCS3 expression and down-regulation of IL-6-mediated gene induction; and for IFNG-dependent gene transcription. Has a role in osteoclast differentiation through NF-kappa-B transactivation by TNFSF11, and in endochondral ossification and since SOX9 is another likely downstream target of the p38 MAPK pathway. MAP2K6/MKK6 mediates apoptotic cell death in thymocytes. Acts also as a regulator for melanocytes dendricity, through the modulation of Rho family GTPases.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDP52564
UniProtKB Entry NameMP2K6_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0020850|Dual specificity mitogen-activated protein kinase kinase 6 (MAP2K6)
ATGTCTCAGTCGAAAGGCAAGAAGCGAAACCCTGGCCTTAAAATTCCAAAAGAAGCATTT
GAACAACCTCAGACCAGTTCCACACCACCTCGAGATTTAGACTCCAAGGCTTGCATTTCT
ATTGGAAATCAGAACTTTGAGGTGAAGGCAGATGACCTGGAGCCTATAATGGAACTGGGA
CGAGGTGCGTACGGGGTGGTGGAGAAGATGCGGCACGTGCCCAGCGGGCAGATCATGGCA
GTGAAGCGGATCCGAGCCACAGTAAATAGCCAGGAACAGAAACGGCTACTGATGGATTTG
GATATTTCCATGAGGACGGTGGACTGTCCATTCACTGTCACCTTTTATGGCGCACTGTTT
CGGGAGGGTGATGTGTGGATCTGCATGGAGCTCATGGATACATCACTAGATAAATTCTAC
AAACAAGTTATTGATAAAGGCCAGACAATTCCAGAGGACATCTTAGGGAAAATAGCAGTT
TCTATTGTAAAAGCATTAGAACATTTACATAGTAAGCTGTCTGTCATTCACAGAGACGTC
AAGCCTTCTAATGTACTCATCAATGCTCTCGGTCAAGTGAAGATGTGCGATTTTGGAATC
AGTGGCTACTTGGTGGACTCTGTTGCTAAAACAATTGATGCAGGTTGCAAACCATACATG
GCCCCTGAAAGAATAAACCCAGAGCTCAACCAGAAGGGATACAGTGTGAAGTCTGACATT
TGGAGTCTGGGCATCACGATGATTGAGTTGGCCATCCTTCGATTTCCCTATGATTCATGG
GGAACTCCATTTCAGCAGCTCAAACAGGTGGTAGAGGAGCCATCGCCACAACTCCCAGCA
GACAAGTTCTCTGCAGAGTTTGTTGACTTTACCTCACAGTGCTTAAAGAAGAATTCCAAA
GAACGGCCTACATACCCAGAGCTAATGCAACATCCATTTTTCACCCTACATGAATCCAAA
GGAACAGATGTGGCATCTTTTGTAAAACTGATTCTTGGAGACTAA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:6846
Chromosome Location17
LocusNot Available
References
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