DNA-directed RNA polymerases I, II, and III subunit RPABC3

NameDNA-directed RNA polymerases I, II, and III subunit RPABC3
Synonyms
  • DNA-directed RNA polymerase II subunit H
  • DNA-directed RNA polymerases I, II, and III 17.1 kDa polypeptide
  • hRPB8
  • RNA polymerases I, II, and III subunit ABC3
  • RPB17
  • RPB8 homolog
Gene NamePOLR2H
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009032|DNA-directed RNA polymerases I, II, and III subunit RPABC3
MAGILFEDIFDVKDIDPEGKKFDRVSRLHCESESFKMDLILDVNIQIYPVDLGDKFRLVI
ASTLYEDGTLDDGEYNPTDDRPSRADQFEYVMYGKVYRIEGDETSTEAATRLSAYVSYGG
LLMRLQGDANNLHGFEVDSRVYLLMKKLAF
Number of residues150
Molecular Weight17143.115
Theoretical pINot Available
GO Classification
Functions
  • DNA binding
  • DNA-directed RNA polymerase activity
Processes
  • mRNA splicing, via spliceosome
  • nucleotide-excision repair
  • piRNA metabolic process
  • transcription from RNA polymerase II promoter
  • positive regulation of viral transcription
  • RNA splicing
  • gene expression
  • transcription elongation from RNA polymerase II promoter
  • transcription initiation from RNA polymerase II promoter
  • innate immune response
  • termination of RNA polymerase I transcription
  • somatic stem cell population maintenance
  • termination of RNA polymerase III transcription
  • transcription-coupled nucleotide-excision repair
  • transcription elongation from RNA polymerase I promoter
  • viral process
  • transcription elongation from RNA polymerase III promoter
  • negative regulation of gene expression, epigenetic
  • transcription from RNA polymerase I promoter
  • regulation of gene expression, epigenetic
  • transcription from RNA polymerase III promoter
  • positive regulation of type I interferon production
  • transcription initiation from RNA polymerase I promoter
  • 7-methylguanosine mRNA capping
  • DNA repair
  • gene silencing by RNA
Components
  • DNA-directed RNA polymerase II, core complex
  • DNA-directed RNA polymerase I complex
  • cytosol
  • DNA-directed RNA polymerase III complex
  • nucleoplasm
  • nucleus
General FunctionDna-directed rna polymerase activity
Specific FunctionDNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDP52434
UniProtKB Entry NameRPAB3_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0017671|DNA-directed RNA polymerases I, II, and III subunit RPABC3 (POLR2H)
ATGGCGGGCATCCTGTTTGAGGATATTTTCGATGTGAAGGATATTGACCCGGAGGGCAAG
AAGTTTGACCGAGTGTCTCGACTGCATTGTGAGAGTGAATCTTTCAAGATGGATCTAATC
TTAGATGTAAACATTCAAATTTACCCTGTAGACTTGGGTGACAAGTTTCGGTTGGTCATA
GCTAGTACCTTGTATGAAGATGGTACCCTGGATGATGGTGAATACAACCCCACTGATGAT
AGGCCTTCCAGGGCTGACCAGTTTGAGTATGTAATGTATGGAAAAGTGTACAGGATTGAG
GGAGATGAAACTTCTACTGAAGCAGCAACACGCCTGCTGAGATTGAGAGCTGCTGAGTGG
CAGTGCTCCAGAATCACGGGATGGGGCCTTCTGTTTCAGCTCTGCGTACGTGTCCTATGG
GGGCCTGCTCATGAGGCTGCAGGGGGATGCCAACAACCTGCATGGATTCGAGGTGGACTC
CAGAGTTTATCTCCTGATGAAGAAGCTAGCCTTCTGAACCTCGCCTGA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:9195
Chromosome Location3
LocusNot Available
References
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  2. Shpakovski GV, Acker J, Wintzerith M, Lacroix JF, Thuriaux P, Vigneron M: Four subunits that are shared by the three classes of RNA polymerase are functionally interchangeable between Homo sapiens and Saccharomyces cerevisiae. Mol Cell Biol. 1995 Sep;15(9):4702-10. 7651387
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