DNA-directed RNA polymerases I, II, and III subunit RPABC3

NameDNA-directed RNA polymerases I, II, and III subunit RPABC3
Synonyms
  • DNA-directed RNA polymerase II subunit H
  • DNA-directed RNA polymerases I, II, and III 17.1 kDa polypeptide
  • hRPB8
  • RNA polymerases I, II, and III subunit ABC3
  • RPB17
  • RPB8 homolog
Gene NamePOLR2H
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009032|DNA-directed RNA polymerases I, II, and III subunit RPABC3
MAGILFEDIFDVKDIDPEGKKFDRVSRLHCESESFKMDLILDVNIQIYPVDLGDKFRLVI
ASTLYEDGTLDDGEYNPTDDRPSRADQFEYVMYGKVYRIEGDETSTEAATRLSAYVSYGG
LLMRLQGDANNLHGFEVDSRVYLLMKKLAF
Number of residues150
Molecular Weight17143.115
Theoretical pINot Available
GO Classification
Functions
  • DNA binding
  • DNA-directed RNA polymerase activity
Processes
  • transcription elongation from RNA polymerase II promoter
  • transcription initiation from RNA polymerase II promoter
  • termination of RNA polymerase I transcription
  • innate immune response
  • termination of RNA polymerase III transcription
  • somatic stem cell population maintenance
  • transcription elongation from RNA polymerase I promoter
  • transcription-coupled nucleotide-excision repair
  • transcription elongation from RNA polymerase III promoter
  • viral process
  • transcription from RNA polymerase I promoter
  • negative regulation of gene expression, epigenetic
  • transcription from RNA polymerase III promoter
  • regulation of gene expression, epigenetic
  • transcription initiation from RNA polymerase I promoter
  • positive regulation of type I interferon production
  • DNA repair
  • 7-methylguanosine mRNA capping
  • gene silencing by RNA
  • nucleotide-excision repair
  • mRNA splicing, via spliceosome
  • transcription from RNA polymerase II promoter
  • piRNA metabolic process
  • positive regulation of viral transcription
  • RNA splicing
  • gene expression
Components
  • DNA-directed RNA polymerase I complex
  • cytosol
  • DNA-directed RNA polymerase III complex
  • nucleoplasm
  • nucleus
  • DNA-directed RNA polymerase II, core complex
General FunctionDna-directed rna polymerase activity
Specific FunctionDNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDP52434
UniProtKB Entry NameRPAB3_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0017671|DNA-directed RNA polymerases I, II, and III subunit RPABC3 (POLR2H)
ATGGCGGGCATCCTGTTTGAGGATATTTTCGATGTGAAGGATATTGACCCGGAGGGCAAG
AAGTTTGACCGAGTGTCTCGACTGCATTGTGAGAGTGAATCTTTCAAGATGGATCTAATC
TTAGATGTAAACATTCAAATTTACCCTGTAGACTTGGGTGACAAGTTTCGGTTGGTCATA
GCTAGTACCTTGTATGAAGATGGTACCCTGGATGATGGTGAATACAACCCCACTGATGAT
AGGCCTTCCAGGGCTGACCAGTTTGAGTATGTAATGTATGGAAAAGTGTACAGGATTGAG
GGAGATGAAACTTCTACTGAAGCAGCAACACGCCTGCTGAGATTGAGAGCTGCTGAGTGG
CAGTGCTCCAGAATCACGGGATGGGGCCTTCTGTTTCAGCTCTGCGTACGTGTCCTATGG
GGGCCTGCTCATGAGGCTGCAGGGGGATGCCAACAACCTGCATGGATTCGAGGTGGACTC
CAGAGTTTATCTCCTGATGAAGAAGCTAGCCTTCTGAACCTCGCCTGA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:9195
Chromosome Location3
LocusNot Available
References
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  2. Shpakovski GV, Acker J, Wintzerith M, Lacroix JF, Thuriaux P, Vigneron M: Four subunits that are shared by the three classes of RNA polymerase are functionally interchangeable between Homo sapiens and Saccharomyces cerevisiae. Mol Cell Biol. 1995 Sep;15(9):4702-10. 7651387
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