NameRho-related GTP-binding protein RhoN
Synonyms
  • ARHN
  • Rho family GTPase 2
  • Rho-related GTP-binding protein Rho7
  • RHO7
  • Rnd2
Gene NameRND2
OrganismHuman
Amino acid sequence
>lcl|BSEQ0013616|Rho-related GTP-binding protein RhoN
MEGQSGRCKIVVVGDAECGKTALLQVFAKDAYPGSYVPTVFENYTASFEIDKRRIELNMW
DTSGSSYYDNVRPLAYPDSDAVLICFDISRPETLDSVLKKWQGETQEFCPNAKVVLVGCK
LDMRTDLATLRELSKQRLIPVTHEQGTVLAKQVGAVSYVECSSRSSERSVRDVFHVATVA
SLGRGHRQLRRTDSRRGMQRSAQLSGRPDRGNEGEIHKDRAKSCNLM
Number of residues227
Molecular Weight25368.54
Theoretical pINot Available
GO Classification
Functions
  • GTP binding
  • GTPase activity
Processes
  • small GTPase mediated signal transduction
  • positive regulation of collateral sprouting
  • signal transduction
Components
  • early endosome
  • acrosomal membrane
General FunctionGtpase activity
Specific FunctionMay be specifically involved in neuronal and hepatic functions. Is a C3 toxin-insensitive member of the Rho subfamily (By similarity).
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDP52198
UniProtKB Entry NameRND2_HUMAN
Cellular LocationCytoplasmic vesicle
Gene sequence
>lcl|BSEQ0013617|Rho-related GTP-binding protein RhoN (RND2)
ATGGAGGGGCAGAGCGGCCGCTGCAAGATCGTGGTGGTGGGAGACGCAGAGTGCGGCAAG
ACGGCGCTGCTGCAGGTGTTCGCCAAGGACGCCTATCCCGGGAGTTATGTCCCCACCGTG
TTTGAGAACTACACTGCGAGCTTTGAGATCGACAAGCGCCGCATTGAGCTCAACATGTGG
GACACTTCAGGTTCCTCTTACTATGATAATGTCCGGCCTCTGGCCTATCCTGATTCTGAT
GCTGTGCTCATCTGCTTCGACATTAGCCGACCAGAAACACTGGACAGTGTTCTCAAGAAG
TGGCAAGGAGAGACTCAAGAGTTCTGCCCCAATGCCAAGGTTGTGCTGGTTGGCTGTAAA
CTGGACATGCGGACTGACCTGGCCACACTGAGGGAGCTGTCCAAGCAGAGGCTTATCCCT
GTTACACATGAGCAGGGCACTGTGCTGGCCAAGCAGGTGGGGGCTGTGTCCTATGTTGAG
TGCTCCTCCCGGTCCTCTGAGCGCAGCGTCAGGGATGTCTTCCATGTGGCTACAGTGGCC
TCCCTTGGCCGTGGCCATAGGCAGCTGCGCCGAACTGACTCACGCCGGGGAATGCAGCGA
TCCGCTCAGCTGTCAGGACGGCCAGACCGGGGGAATGAGGGCGAGATACACAAGGATCGA
GCCAAAAGCTGCAACCTCATGTGA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:18315
Chromosome Location17
LocusNot Available
References
  1. Nobes CD, Lauritzen I, Mattei MG, Paris S, Hall A, Chardin P: A new member of the Rho family, Rnd1, promotes disassembly of actin filament structures and loss of cell adhesion. J Cell Biol. 1998 Apr 6;141(1):187-97. 9531558
  2. Smith TM, Lee MK, Szabo CI, Jerome N, McEuen M, Taylor M, Hood L, King MC: Complete genomic sequence and analysis of 117 kb of human DNA containing the gene BRCA1. Genome Res. 1996 Nov;6(11):1029-49. 8938427
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  5. Naud N, Toure A, Liu J, Pineau C, Morin L, Dorseuil O, Escalier D, Chardin P, Gacon G: Rho family GTPase Rnd2 interacts and co-localizes with MgcRacGAP in male germ cells. Biochem J. 2003 May 15;372(Pt 1):105-12. 12590651
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