3-oxo-5-beta-steroid 4-dehydrogenase

Name3-oxo-5-beta-steroid 4-dehydrogenase
Synonyms
  • 1.3.1.3
  • Aldo-keto reductase family 1 member D1
  • Delta(4)-3-ketosteroid 5-beta-reductase
  • Delta(4)-3-oxosteroid 5-beta-reductase
  • SRD5B1
Gene NameAKR1D1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0006946|3-oxo-5-beta-steroid 4-dehydrogenase
MDLSAASHRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQN
EHEVGEAIREKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIE
VPMAFKPGDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELIL
NKPGLKHKPVSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLK
DALLNSLGKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIE
ALNKNVRFVELLMWRDHPEYPFHDEY
Number of residues326
Molecular Weight37376.615
Theoretical pI7.58
GO Classification
Functions
  • delta4-3-oxosteroid 5beta-reductase activity
  • steroid binding
Processes
  • bile acid metabolic process
  • bile acid catabolic process
  • C21-steroid hormone metabolic process
  • cholesterol catabolic process
  • digestion
  • small molecule metabolic process
  • oxidation-reduction process
  • androgen metabolic process
  • bile acid biosynthetic process
Components
  • cytosol
  • extracellular exosome
General FunctionSteroid binding
Specific FunctionEfficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites. The bile acid intermediates 7-alpha,12-alpha-dihydroxy-4-cholesten-3-one and 7-alpha-hydroxy-4-cholesten-3-one can also act as substrates.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID431857
UniProtKB IDP51857
UniProtKB Entry NameAK1D1_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0012510|3-oxo-5-beta-steroid 4-dehydrogenase (AKR1D1)
ATGGATCTCAGTGCTGCAAGTCACCGCATACCTCTAAGTGATGGAAACAGCATTCCCATC
ATCGGACTTGGTACCTACTCAGAACCTAAATCGACCCCTAAGGGAGCCTGTGCAACATCG
GTGAAGGTTGCTATTGACACAGGGTACCGACATATTGATGGGGCCTACATCTACCAAAAT
GAACACGAAGTTGGGGAGGCCATCAGGGAGAAGATAGCAGAAGGAAAGGTGCGGAGGGAA
GATATCTTCTACTGTGGAAAGCTATGGGCTACAAATCATGTCCCAGAGATGGTCCGCCCA
ACCCTGGAGAGGACACTCAGGGTCCTCCAGCTAGATTATGTGGATCTTTACATCATTGAA
GTACCCATGGCCTTTAAGCCAGGAGATGAAATATACCCTAGAGATGAGAATGGCAAATGG
TTATATCACAAGTCAAATCTGTGTGCCACTTGGGAGGTTGAGTGCCATCCGTATTTCACC
CAGCCAAAACTCTTGAAATTTTGCCAACAACATGACATTGTCATTACTGCATATAGCCCT
TTGGGGACCAGTAGGAATCCAATCTGGGTGAATGTTTCTTCTCCACCTTTGTTAAAGGAT
GCACTTCTAAACTCATTGGGGAAAAGGTACAATAAGACAGCAGCTCAAATTGTTTTGCGT
TTCAACATCCAGCGAGGGGTGGTTGTCATTCCTAAAAGCTTTAATCTTGAAAGGATCAAA
GAAAATTTTCAGATCTTTGACTTTTCTCTCACTGAAGAAGAAATGAAGGACATTGAAGCC
TTGAATAAAAATGTCCGCTTTGTAGAATTGCTCATGTGGCGCGATCATCCTGAATACCCA
TTTCATGATGAATACTGA
GenBank Gene IDZ28339
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:388
Chromosome Location7
Locus7q32-q33
References
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