NameH(+)/Cl(-) exchange transporter 7
Synonyms
  • Chloride channel 7 alpha subunit
  • Chloride channel protein 7
  • ClC-7
Gene NameCLCN7
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009056|H(+)/Cl(-) exchange transporter 7
MANVSKKVSWSGRDRDDEEAAPLLRRTARPGGGTPLLNGAGPGAARQSPRSALFRVGHMS
SVELDDELLDPDMDPPHPFPKEIPHNEKLLSLKYESLDYDNSENQLFLEEERRINHTAFR
TVEIKRWVICALIGILTGLVACFIDIVVENLAGLKYRVIKGNIDKFTEKGGLSFSLLLWA
TLNAAFVLVGSVIVAFIEPVAAGSGIPQIKCFLNGVKIPHVVRLKTLVIKVSGVILSVVG
GLAVGKEGPMIHSGSVIAAGISQGRSTSLKRDFKIFEYFRRDTEKRDFVSAGAAAGVSAA
FGAPVGGVLFSLEEGASFWNQFLTWRIFFASMISTFTLNFVLSIYHGNMWDLSSPGLINF
GRFDSEKMAYTIHEIPVFIAMGVVGGVLGAVFNALNYWLTMFRIRYIHRPCLQVIEAVLV
AAVTATVAFVLIYSSRDCQPLQGGSMSYPLQLFCADGEYNSMAAAFFNTPEKSVVSLFHD
PPGSYNPLTLGLFTLVYFFLACWTYGLTVSAGVFIPSLLIGAAWGRLFGISLSYLTGAAI
WADPGKYALMGAAAQLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVFIEG
LYDMHIQLQSVPFLHWEAPVTSHSLTAREVMSTPVTCLRRREKVGVIVDVLSDTASNHNG
FPVVEHADDTQPARLQGLILRSQLIVLLKHKVFVERSNLGLVQRRLRLKDFRDAYPRFPP
IQSIHVSQDERECTMDLSEFMNPSPYTVPQEASLPRVFKLFRALGLRHLVVVDNRNQVVG
LVTRKDLARYRLGKRGLEELSLAQT
Number of residues805
Molecular Weight88678.26
Theoretical pINot Available
GO Classification
Functions
  • antiporter activity
  • ATP binding
  • chloride channel activity
  • voltage-gated chloride channel activity
Processes
  • transmembrane transport
  • ion transmembrane transport
  • chloride transmembrane transport
  • response to pH
  • transport
Components
  • integral component of membrane
  • lysosomal membrane
  • membrane
  • cytoplasmic vesicle
General FunctionVoltage-gated chloride channel activity
Specific FunctionSlowly voltage-gated channel mediating the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the lysosome lumen.
Pfam Domain Function
Transmembrane Regions127-159 174-197 223-241 247-264 322-341 375-405 410-432 487-507 512-535 579-597
GenBank Protein IDNot Available
UniProtKB IDP51798
UniProtKB Entry NameCLCN7_HUMAN
Cellular LocationLysosome membrane
Gene sequence
>lcl|BSEQ0019712|H(+)/Cl(-) exchange transporter 7 (CLCN7)
ATGGCCAACGTCTCTAAGAAGGTGTCCTGGTCCGGCCGGGACCGGGACGACGAGGAGGCG
GCGCCGCTGCTGCGGAGGACGGCGCGGCCCGGCGGGGGGACGCCGCTGCTGAACGGGGCT
GGGCCTGGGGCTGCGCGCCAGGATATGGACCCTCCACATCCCTTCCCCAAGGAGATCCCA
CACAACGAGAAGCTCCTGTCCCTCAAGTATGAGAGCTTGGACTATGACAACAGTGAGAAC
CAGCTGTTCCTGGAGGAGGAGCGGCGGATCAATCACACGGCCTTCCGGACGGTGGAGATC
AAGCGCTGGGTCATCTGCGCCCTCATTGGGATCCTCACGGGCCTCGTGGCCTGCTTCATT
GACATCGTGGTGGAAAACCTGGCTGGCCTCAAGTACAGGGTCATCAAGGGCAATATCGAC
AAGTTCACAGAGAAGGGCGGACTGTCCTTCTCCCTGTTGCTGTGGGCCACGCTGAACGCC
GCCTTCGTGCTCGTGGGCTCTGTGATTGTGGCTTTCATAGAGCCGGTGGCTGCTGGCAGC
GGAATCCCCCAGATCAAGTGCTTCCTCAACGGGGTGAAGATCCCCCACGTGGTGCGGCTC
AAGACGTTGGTGATCAAAGTGTCCGGTGTGATCCTGTCCGTGGTCGGGGGCCTGGCCGTG
GGAAAGGAAGGGCCGATGATCCACTCAGGTTCAGTGATTGCCGCCGGGATCTCTCAGGGA
AGGTCAACGTCACTGAAACGAGATTTCAAGATCTTCGAGTACTTCCGCAGAGACACAGAG
AAGCGGGACTTCGTCTCCGCAGGGGCTGCGGCCGGAGTGTCAGCGGCGTTTGGAGCCCCC
GTGGGTGGGGTCCTGTTCAGCTTGGAGGAGGGTGCGTCCTTCTGGAACCAGTTCCTGACC
TGGAGGATCTTCTTTGCTTCCATGATCTCCACGTTCACCCTGAATTTTGTTCTGAGCATT
TACCACGGGAACATGTGGGACCTGTCCAGCCCAGGCCTCATCAACTTCGGAAGGTTTGAC
TCGGAGAAAATGGCCTACACGATCCACGAGATCCCGGTCTTCATCGCCATGGGCGTGGTG
GGCGGTGTGCTTGGAGCAGTGTTCAATGCCTTGAACTACTGGCTGACCATGTTTCGAATC
AGGTACATCCACCGGCCCTGCCTGCAGGTGATTGAGGCCGTGCTGGTGGCCGCCGTCACG
GCCACAGTTGCCTTCGTGCTGATCTACTCGTCGCGGGATTGCCAGCCCCTGCAGGGGGGC
TCCATGTCCTACCCGCTGCAGCTCTTTTGTGCAGATGGCGAGTACAACTCCATGGCTGCG
GCCTTCTTCAACACCCCGGAGAAGAGCGTGGTGAGCCTCTTCCACGACCCGCCAGGCTCC
TACAACCCCCTGACCCTCGGCCTGTTCACGCTGGTCTACTTCTTCCTGGCCTGCTGGACC
TACGGGCTCACGGTGTCTGCCGGGGTCTTCATCCCGTCCCTGCTCATCGGGGCTGCCTGG
GGCCGGCTCTTTGGGATCTCCCTGTCCTACCTCACGGGGGCGGCGATCTGGGCGGACCCC
GGCAAATACGCCCTGATGGGAGCTGCTGCCCAGCTGGGCGGGATTGTGCGGATGACACTG
AGCCTGACCGTCATCATGATGGAGGCCACCAGCAACGTGACCTACGGCTTCCCCATCATG
CTGGTGCTCATGACCGCCAAGATCGTGGGCGACGTCTTCATTGAGGGCCTGTACGACATG
CACATTCAGCTGCAGAGTGTGCCCTTCCTGCACTGGGAGGCCCCGGTCACCTCACACTCA
CTCACTGCCAGGGAGGTGATGAGCACACCAGTGACCTGCCTGAGGCGGCGTGAGAAGGTC
GGCGTCATTGTGGACGTGCTGAGCGACACGGCGTCCAATCACAACGGCTTCCCCGTGGTG
GAGCATGCCGATGACACCCAGCCTGCCCGGCTCCAGGGCCTGATCCTGCGCTCCCAGCTC
ATCGTTCTCCTAAAGCACAAGGTGTTTGTGGAGCGGTCCAACCTGGGCCTGGTACAGCGG
CGCCTGAGGCTGAAGGACTTCCGAGACGCCTACCCGCGCTTCCCACCCATCCAGTCCATC
CACGTGTCCCAGGACGAGCGGGAGTGCACCATGGACCTCTCCGAGTTCATGAACCCCTCC
CCCTACACGGTGCCCCAGGAGGCGTCGCTCCCACGGGTGTTCAAGCTGTTCCGGGCCCTG
GGCCTGCGGCACCTGGTGGTGGTGGACAACCGCAATCAGGTTGTCGGGTTGGTGACCAGG
AAGGACCTCGCCAGGTACCGCCTGGGAAAGAGAGGCTTGGAGGAGCTCTCGCTGGCCCAG
ACGTGA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:2025
Chromosome Location16
LocusNot Available
References
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