Guanine nucleotide-binding protein G(q) subunit alpha

NameGuanine nucleotide-binding protein G(q) subunit alpha
Synonyms
  • GAQ
  • Guanine nucleotide-binding protein alpha-q
Gene NameGNAQ
OrganismHuman
Amino acid sequence
>lcl|BSEQ0013619|Guanine nucleotide-binding protein G(q) subunit alpha
MTLESIMACCLSEEAKEARRINDEIERQLRRDKRDARRELKLLLLGTGESGKSTFIKQMR
IIHGSGYSDEDKRGFTKLVYQNIFTAMQAMIRAMDTLKIPYKYEHNKAHAQLVREVDVEK
VSAFENPYVDAIKSLWNDPGIQECYDRRREYQLSDSTKYYLNDLDRVADPAYLPTQQDVL
RVRVPTTGIIEYPFDLQSVIFRMVDVGGQRSERRKWIHCFENVTSIMFLVALSEYDQVLV
ESDNENRMEESKALFRTIITYPWFQNSSVILFLNKKDLLEEKIMYSHLVDYFPEYDGPQR
DAQAAREFILKMFVDLNPDSDKIIYSHFTCATDTENIRFVFAAVKDTILQLNLKEYNLV
Number of residues359
Molecular Weight42141.67
Theoretical pINot Available
GO Classification
Functions
  • G-protein beta/gamma-subunit complex binding
  • type 2A serotonin receptor binding
  • signal transducer activity
  • GTP binding
  • GTPase activity
  • metal ion binding
  • GTPase activator activity
Processes
  • embryonic digit morphogenesis
  • protein stabilization
  • skeletal system development
  • post-embryonic development
  • heart development
  • G-protein coupled acetylcholine receptor signaling pathway
  • developmental pigmentation
  • entrainment of circadian clock
  • forebrain neuron development
  • phototransduction, visible light
  • neuron remodeling
  • positive regulation of GTPase activity
  • regulation of catenin import into nucleus
  • adenylate cyclase-activating G-protein coupled receptor signaling pathway
  • blood coagulation
  • regulation of melanocyte differentiation
  • phospholipase C-activating dopamine receptor signaling pathway
  • activation of phospholipase C activity
  • maternal behavior
  • platelet activation
  • glutamate receptor signaling pathway
  • action potential
  • negative regulation of protein kinase activity
Components
  • extracellular exosome
  • nuclear membrane
  • photoreceptor outer segment
  • cytoplasm
  • plasma membrane
  • heterotrimeric G-protein complex
  • lysosomal membrane
General FunctionType 2a serotonin receptor binding
Specific FunctionGuanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity. Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro) (By similarity).
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDP50148
UniProtKB Entry NameGNAQ_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0013620|Guanine nucleotide-binding protein G(q) subunit alpha (GNAQ)
ATGACTCTGGAGTCCATCATGGCGTGCTGCCTGAGCGAGGAGGCCAAGGAAGCCCGGCGG
ATCAACGACGAGATCGAGCGGCAGCTCCGCAGGGACAAGCGGGACGCCCGCCGGGAGCTC
AAGCTGCTGCTGCTCGGGACAGGAGAGAGTGGCAAGAGTACGTTTATCAAGCAGATGAGA
ATCATCCATGGGTCAGGATACTCTGATGAAGATAAAAGGGGCTTCACCAAGCTGGTGTAT
CAGAACATCTTCACGGCCATGCAGGCCATGATCAGAGCCATGGACACACTCAAGATCCCA
TACAAGTATGAGCACAATAAGGCTCATGCACAATTAGTTCGAGAAGTTGATGTGGAGAAG
GTGTCTGCTTTTGAGAATCCATATGTAGATGCAATAAAGAGTTTATGGAATGATCCTGGA
ATCCAGGAATGCTATGATAGACGACGAGAATATCAATTATCTGACTCTACCAAATACTAT
CTTAATGACTTGGACCGCGTAGCTGACCCTGCCTACCTGCCTACGCAACAAGATGTGCTT
AGAGTTCGAGTCCCCACCACAGGGATCATCGAATACCCCTTTGACTTACAAAGTGTCATT
TTCAGAATGGTCGATGTAGGGGGCCAAAGGTCAGAGAGAAGAAAATGGATACACTGCTTT
GAAAATGTCACCTCTATCATGTTTCTAGTAGCGCTTAGTGAATATGATCAAGTTCTCGTG
GAGTCAGACAATGAGAACCGAATGGAGGAAAGCAAGGCTCTCTTTAGAACAATTATCACA
TACCCCTGGTTCCAGAACTCCTCGGTTATTCTGTTCTTAAACAAGAAAGATCTTCTAGAG
GAGAAAATCATGTATTCCCATCTAGTCGACTACTTCCCAGAATATGATGGACCCCAGAGA
GATGCCCAGGCAGCCCGAGAATTCATTCTGAAGATGTTCGTGGACCTGAACCCAGACAGT
GACAAAATTATCTACTCCCACTTCACGTGCGCCACAGACACCGAGAATATCCGCTTTGTC
TTTGCTGCCGTCAAGGACACCATCCTCCAGTTGAACCTGAAGGAGTACAATCTGGTCTAA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:4390
Chromosome Location9
LocusNot Available
References
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