NameRetinol-binding protein 2
Synonyms
  • Cellular retinol-binding protein II
  • CRBP-II
  • CRBP2
Gene NameRBP2
OrganismHuman
Amino acid sequence
>lcl|BSEQ0010355|Retinol-binding protein 2
MTRDQNGTWEMESNENFEGYMKALDIDFATRKIAVRLTQTKVIDQDGDNFKTKTTSTFRN
YDVDFTVGVEFDEYTKSLDNRHVKALVTWEGDVLVCVQKGEKENRGWKQWIEGDKLYLEL
TCGDQVCRQVFKKK
Number of residues134
Molecular Weight15706.595
Theoretical pI5.04
GO Classification
Functions
  • transporter activity
  • retinoid binding
  • retinal binding
  • retinol binding
Processes
  • vitamin A metabolic process
  • epidermis development
  • phototransduction, visible light
  • retinoid metabolic process
Components
  • cytosol
General FunctionTransporter activity
Specific FunctionIntracellular transport of retinol.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID535390
UniProtKB IDP50120
UniProtKB Entry NameRET2_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0010356|Retinol-binding protein 2 (RBP2)
ATGACAAGGGACCAGAATGGAACCTGGGAGATGGAGAGTAATGAAAACTTTGAGGGCTAC
ATGAAGGCCCTGGATATTGATTTTGCCACCCGCAAGATTGCAGTACGTCTCACTCAGACG
AAGGTTATTGATCAAGATGGTGATAACTTCAAGACAAAAACCACTAGCACATTCCGCAAC
TATGATGTGGATTTCACTGTTGGAGTAGAGTTTGACGAGTACACAAAGAGCCTGGATAAC
CGGCATGTTAAGGCACTGGTCACCTGGGAAGGTGATGTCCTTGTGTGTGTGCAAAAGGGG
GAGAAGGAGAACCGCGGCTGGAAGCAGTGGATTGAGGGGGACAAGCTGTACCTGGAGCTG
ACCTGTGGTGACCAGGTGTGCCGTCAAGTGTTCAAAAAGAAATGA
GenBank Gene IDU13831
GeneCard IDNot Available
GenAtlas IDRBP2
HGNC IDHGNC:9920
Chromosome Location3
Locus3q23
References
  1. Loughney AD, Kumarendran MK, Thomas EJ, Redfern CP: Variation in the expression of cellular retinoid binding proteins in human endometrium throughout the menstrual cycle. Hum Reprod. 1995 May;10(5):1297-304. 7657783
  2. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. 14702039
  3. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. 15489334
  4. Folli C, Calderone V, Ottonello S, Bolchi A, Zanotti G, Stoppini M, Berni R: Identification, retinoid binding, and x-ray analysis of a human retinol-binding protein. Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):3710-5. 11274389
  5. Tarter M, Capaldi S, Carrizo ME, Ambrosi E, Perduca M, Monaco HL: Crystal structure of human cellular retinol-binding protein II to 1.2 A resolution. Proteins. 2008 Mar;70(4):1626-30. 18076076