NameAlpha-mannosidase 2x
Synonyms
  • 3.2.1.114
  • Alpha-mannosidase IIx
  • Man IIx
  • MANA2X
  • Mannosidase alpha class 2A member 2
  • Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase
Gene NameMAN2A2
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009085|Alpha-mannosidase 2x
MKLKKQVTVCGAAIFCVAVFSLYLMLDRVQHDPTRHQNGGNFPRSQISVLQNRIEQLEQL
LEENHEIISHIKDSVLELTANAEGPPAMLPYYTVNGSWVVPPEPRPSFFSISPQDCQFAL
GGRGQKPELQMLTVSEELPFDNVDGGVWRQGFDISYDPHDWDAEDLQVFVVPHSHNDPGW
IKTFDKYYTEQTQHILNSMVSKLQEDPRRRFLWAEVSFFAKWWDNINVQKRAAVRRLVGN
GQLEIATGGWVMPDEANSHYFALIDQLIEGHQWLERNLGATPRSGWAVDPFGYSSTMPYL
LRRANLTSMLIQRVHYAIKKHFAATHSLEFMWRQTWDSDSSTDIFCHMMPFYSYDVPHTC
GPDPKICCQFDFKRLPGGRINCPWKVPPRAITEANVAERAALLLDQYRKKSQLFRSNVLL
VPLGDDFRYDKPQEWDAQFFNYQRLFDFFNSRPNLHVQAQFGTLSDYFDALYKRTGVEPG
ARPPGFPVLSGDFFSYADREDHYWTGYYTSRPFYKSLDRVLEAHLRGAEVLYSLAAAHAR
RSGLAGRYPLSDFTLLTEARRTLGLFQHHDAITGTAKEAVVVDYGVRLLRSLVNLKQVII
HAAHYLVLGDKETYHFDPEAPFLQVDDTRLSHDALPERTVIQLDSSPRFVVLFNPLEQER
FSMVSLLVNSPRVRVLSEEGQPLAVQISAHWSSATEAVPDVYQVSVPVRLPALGLGVLQL
QLGLDGHRTLPSSVRIYLHGRQLSVSRHEAFPLRVIDSGTSDFALSNRYMQVWFSGLTGL
LKSIRRVDEEHEQQVDMQVLVYGTRTSKDKSGAYLFLPDGEAKPYVPKEPPVLRVTEGPF
FSEVVAYYEHIHQAVRLYNLPGVEGLSLDISSLVDIRDYVNKELALHIHTDIDSQGIFFT
DLNGFQVQPRRYLKKLPLQANFYPMPVMAYIQDAQKRLTLHTAQALGVSSLKDGQLEVIL
DRRLMQDDNRGLGQGLKDNKRTCNRFRLLLERRTVGSEVQDSHSTSYPSLLSHLTSMYLN
APALALPVARMQLPGPGLRSFHPLASSLPCDFHLLNLRTLQAEEDTLPSAETALILHRKG
FDCGLEAKNLGFNCTTSQGKVALGSLFHGLDVVFLQPTSLTLLYPLASPSNSTDVYLEPM
EIATFRLRLG
Number of residues1150
Molecular Weight130537.495
Theoretical pINot Available
GO Classification
Functions
  • mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity
  • zinc ion binding
  • carbohydrate binding
  • hydrolase activity, hydrolyzing N-glycosyl compounds
  • alpha-mannosidase activity
Processes
  • cellular protein metabolic process
  • post-translational protein modification
  • protein N-linked glycosylation via asparagine
  • protein deglycosylation
  • mannose metabolic process
  • N-glycan processing
Components
  • integral component of membrane
  • Golgi membrane
General FunctionZinc ion binding
Specific FunctionCatalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway.
Pfam Domain Function
Transmembrane Regions6-26
GenBank Protein IDNot Available
UniProtKB IDP49641
UniProtKB Entry NameMA2A2_HUMAN
Cellular LocationGolgi apparatus membrane
Gene sequence
>lcl|BSEQ0013604|Alpha-mannosidase 2x (MAN2A2)
ATGAAGCTGAAAAAGCAGGTGACAGTGTGTGGGGCTGCCATCTTCTGTGTGGCAGTCTTC
TCGCTCTACCTCATGCTGGACCGAGTGCAACACGATCCCACCCGACACCAGAATGGTGGG
AACTTCCCCCGGAGCCAAATTTCTGTGCTGCAGAACCGCATTGAGCAGCTGGAGCAGCTT
TTGGAGGAGAACCATGAGATTATCAGCCATATCAAGGACTCCGTGCTGGAGCTGACAGCC
AACGCAGAGGGCCCGCCCGCCATGCTGCCCTACTACACGGTCAATGGCTCCTGGGTGGTG
CCACCGGAGCCCCGGCCCAGCTTCTTCTCCATCTCCCCGCAGGACTGCCAGTTTGCTTTG
GGGGGCCGGGGTCAGAAGCCAGAGCTGCAGATGCTCACTGTGTCGGAGGAGCTGCCGTTT
GACAACGTGGATGGTGGTGTGTGGAGGCAAGGCTTCGACATCTCCTACGACCCGCACGAC
TGGGATGCTGAAGACCTGCAGGTGTTTGTGGTGCCCCACTCTCACAATGACCCAGGCTGG
ATCAAGACCTTTGACAAGTACTACACAGAGCAGACCCAACACATCCTCAATAGCATGGTG
TCTAAGCTGCAGGAGGACCCCCGGCGGCGCTTCCTCTGGGCAGAGGTCTCCTTCTTCGCC
AAGTGGTGGGACAACATCAATGTCCAAAAGAGAGCGGCAGTCCGAAGGCTGGTGGGAAAC
GGGCAGCTGGAGATTGCGACAGGAGGCTGGGTGATGCCAGATGAGGCCAATTCCCACTAC
TTTGCATTGATTGACCAGCTCATCGAAGGACACCAGTGGCTGGAGAGAAATCTTGGTGCA
ACCCCCCGCTCTGGCTGGGCAGTGGACCCCTTTGGATACAGCTCCACCATGCCTTACCTG
CTGCGCCGTGCCAACCTCACCAGCATGCTGATTCAGAGAGTGCACTATGCCATCAAGAAG
CACTTTGCTGCCACCCACAGCCTAGAGTTCATGTGGAGGCAGACATGGGACTCGGACTCC
AGCACAGACATCTTCTGTCACATGATGCCCTTCTACAGCTATGACGTCCCCCATACCTGT
GGCCCAGATCCCAAGATCTGCTGCCAATTTGATTTCAAACGCCTGCCTGGTGGGCGCATC
AACTGCCCTTGGAAGGTGCCACCCCGGGCCATCACAGAGGCCAACGTGGCAGAGAGGGCA
GCCCTGCTTCTGGACCAATACCGGAAGAAGTCCCAGCTGTTCCGAAGCAACGTCCTCCTG
GTGCCTCTTGGAGATGACTTCCGATATGACAAGCCCCAGGAGTGGGATGCCCAGTTCTTC
AACTACCAACGGCTCTTTGACTTCTTCAACAGCAGGCCTAACCTCCATGTGCAGGCCCAG
TTTGGCACTCTTTCTGACTATTTTGATGCCCTGTACAAGAGGACAGGGGTGGAGCCAGGG
GCCCGGCCTCCAGGGTTTCCTGTGCTGAGCGGGGATTTCTTCTCCTATGCGGACCGGGAG
GATCATTACTGGACAGGCTATTACACTTCCCGGCCCTTCTACAAGAGCTTAGACCGAGTC
CTGGAAGCCCACCTGCGGGGGGCAGAGGTTCTGTACAGCCTGGCTGCAGCTCACGCTCGC
CGCTCTGGTCTGGCTGGCCGGTACCCACTGTCTGATTTCACCCTCCTGACGGAAGCTCGG
CGCACATTGGGGCTCTTCCAGCATCACGATGCCATCACTGGCACGGCCAAGGAGGCTGTG
GTGGTGGACTATGGGGTCAGGCTTCTGCGCTCCCTTGTCAACCTGAAGCAGGTCATCATT
CATGCAGCCCACTATCTGGTGCTGGGGGACAAGGAGACCTACCACTTTGACCCTGAGGCG
CCCTTCCTCCAAGTGGATGACACTCGCTTAAGTCACGACGCCCTCCCAGAGCGCACGGTG
ATCCAGCTGGATTCCTCGCCCAGGTTTGTGGTCCTATTCAACCCACTGGAACAGGAGCGA
TTCAGCATGGTGTCCCTGCTGGTCAACTCTCCCCGCGTGCGTGTCCTTTCGGAGGAGGGT
CAGCCCCTGGCCGTGCAGATCAGCGCACACTGGAGCTCTGCCACCGAGGCGGTCCCTGAC
GTCTACCAGGTGTCTGTGCCTGTCCGCCTGCCAGCCCTGGGCCTGGGCGTGCTGCAGCTA
CAGCTGGGCCTGGATGGGCACCGCACGCTGCCCTCCTCTGTGCGCATCTACCTGCACGGC
CGGCAGCTGTCCGTCAGCAGGCACGAAGCGTTTCCTCTCCGTGTCATTGACTCTGGCACC
AGCGACTTCGCCCTCAGCAACCGCTACATGCAGGTCTGGTTCTCAGGCCTTACTGGGCTC
CTCAAGAGCATCCGAAGGGTGGATGAGGAGCACGAGCAGCAGGTGGACATGCAGGTCCTT
GTCTATGGCACCCGTACGTCCAAAGACAAGAGTGGAGCCTACCTCTTCCTGCCCGATGGC
GAGGCCAAGCCCTACGTCCCCAAGGAGCCCCCCGTGCTGCGTGTCACTGAAGGCCCTTTC
TTCTCAGAGGTGGTTGCGTACTATGAGCACATTCACCAGGCGGTCCGGCTTTACAATCTG
CCAGGGGTGGAGGGGCTGTCTCTGGACATATCATCCCTGGTGGACATCCGGGACTACGTC
AACAAGGAGCTGGCCCTGCACATCCATACAGACATCGACAGCCAGGGTATCTTCTTCACA
GACCTCAATGGCTTTCAGGTGCAGCCCCGACGGTATCTGAAGAAGCTCCCCCTCCAGGCC
AACTTCTACCCCATGCCAGTCATGGCCTATATCCAGGACGCACAGAAGCGCCTCACGCTG
CACACTGCCCAGGCCCTGGGTGTCTCTAGCCTCAAAGATGGCCAGCTGGAGGTGATCTTG
GACCGGCGGCTGATGCAGGATGACAACCGGGGCCTAGGCCAAGGGCTCAAGGACAACAAG
AGAACCTGCAACCGTTTCCGCCTCCTGCTAGAGCGGCGAACCGTGGGCAGTGAGGTCCAA
GATAGCCACTCTACCAGCTACCCATCCCTCCTCAGCCACCTGACCTCCATGTACCTGAAC
GCCCCGGCGCTCGCTCTGCCTGTAGCCAGGATGCAGCTCCCAGGCCCTGGTCTGCGCTCA
TTTCATCCTCTGGCTTCCTCACTGCCCTGTGACTTCCACCTGCTCAACCTACGTACGCTC
CAGGCTGAGGAGGACACCCTACCCTCGGCGGAGACCGCACTCATCTTACACCGCAAGGGT
TTTGACTGCGGCCTGGAGGCCAAGAACTTGGGCTTCAACTGCACCACAAGCCAAGGCAAG
GTAGCCCTGGGCAGCCTTTTCCATGGCCTGGATGTGGTATTCCTTCAGCCAACCTCCTTG
ACGTTACTGTACCCTCTGGCCTCCCCGTCCAACAGCACTGACGTCTATTTGGAGCCCATG
GAGATTGCTACCTTTCGCCTCCGCTTGGGTTAG
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:6825
Chromosome Location15
LocusNot Available
References
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