Sodium- and chloride-dependent glycine transporter 1
Name | Sodium- and chloride-dependent glycine transporter 1 |
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Synonyms |
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Gene Name | SLC6A9 |
Organism | Human |
Amino acid sequence | >lcl|BSEQ0037103|Sodium- and chloride-dependent glycine transporter 1 MSGGDTRAAIARPRMAAAHGPVAPSSPEQVTLLPVQRSFFLPPFSGATPSTSLAESVLKV WHGAYNSGLLPQLMAQHSLAMAQNGAVPSEATKRDQNLKRGNWGNQIEFVLTSVGYAVGL GNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVWRISPMFKG VGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTHDCAGVLDASNLTN GSRPAALPSNLSHLLNHSLQRTSPSEEYWRLYVLKLSDDIGNFGEVRLPLLGCLGVSWLV VFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEGAFDGIMYYLTPQWDKILEAKV WGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGF MANHLGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETL VTAIVDEVGNEWILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVIS CIMCVAIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPAIIFFILVFTVIQYQPITY NHYQYPGWAVAIGFLMALSSVLCIPLYAMFRLCRTDGDTLLQRLKNATKPSRDWGPALLE HRTGRYAPTIAPSPEDGFEVQPLHPDKAQIPIVGSNGSSRLQDSRI |
Number of residues | 706 |
Molecular Weight | 78259.625 |
Theoretical pI | 7.74 |
GO Classification | Functions
Processes
Components
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General Function | Neurotransmitter:sodium symporter activity |
Specific Function | Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May play a role in regulation of glycine levels in NMDA receptor-mediated neurotransmission. |
Pfam Domain Function |
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Transmembrane Regions | 109-129 136-156 188-208 286-306 315-335 360-380 407-427 450-470 506-526 530-550 570-590 610-630 |
GenBank Protein ID | 546769 |
UniProtKB ID | P48067 |
UniProtKB Entry Name | SC6A9_HUMAN |
Cellular Location | Membrane |
Gene sequence | >lcl|BSEQ0010660|Sodium- and chloride-dependent glycine transporter 1 (SLC6A9) ATGGTAGGAAAAGGTGCCAAAGGGATGCTGAATGGTGCTGTGCCCAGCGAGGCCACCAAG AGGGACCAGAACCTCAAACGGGGCAACTGGGGCAACCAGATCGAGTTTGTACTGACGAGC GTGGGCTATGCCGTGGGCCTGGGCAATGTCTGGCGCTTCCCATACCTCTGCTATCGCAAC GGGGGAGGCGCCTTCATGTTCCCCTACTTCATCATGCTCATCTTCTGCGGGATCCCCCTC TTCTTCATGGAGCTCTCCTTCGGCCAGTTTGCAAGCCAGGGGTGCCTGGGGGTCTGGAGG ATCAGCCCCATGTTCAAAGGAGTGGGCTATGGTATGATGGTGGTGTCCACCTACATCGGC ATCTACTACAATGTGGTCATCTGCATCGCCTTCTACTACTTCTTCTCGTCCATGACGCAC GTGCTGCCCTGGGCCTACTGCAATAACCCCTGGAACACGCATGACTGCGCCGGTGTACTG GACGCCTCCAACCTCACCAATGGCTCTCGGCCAGCCGCCTTGCCCAGCAACCTCTCCCAC CTGCTCAACCACAGCCTCCAGAGGACCAGCCCCAGCGAGGAGTACTGGAGGCTGTACGTG CTGAAGCTGTCAGATGACATTGGGAACTTTGGGGAGGTGCGGCTGCCCCTCCTTGGCTGC CTCGGTGTCTCCTGGTTGGTCGTCTTCCTCTGCCTCATCCGAGGGGTCAAGTCTTCAGGG AAAGTGGTGTACTTCACGGCCACGTTCCCCTACGTGGTGCTGACCATTCTGTTTGTCCGC GGAGTGACCCTGGAGGGAGCCTTTGACGGCATCATGTACTACCTAACCCCGCAGTGGGAC AAGATCCTGGAGGCCAAGGTGTGGGGTGATGCTGCCTCCCAGATCTTCTACTCACTGGGC TGCGCGTGGGGAGGCCTCATCACCATGGCTTCCTACAACAAGTTCCACAATAACTGTTAC CGGGACAGTGTCATCATCAGCATCACCAACTGTGCCACCAGCGTCTATGCTGGCTTCGTC ATCTTCTCCATCCTCGGCTTCATGGCCAATCACCTGGGCGTGGATGTGTCCCGTGTGGCA GACCACGGCCCTGGCCTGGCCTTCGTGGCTTACCCCGAGGCCCTCACACTACTTCCCATC TCCCCGCTGTGGTCTCTGCTCTTCTTCTTCATGCTTATCCTGCTGGGGCTGGGCACTCAG TTCTGCCTCCTGGAGACGCTGGTCACAGCCATTGTGGATGAGGTGGGGAATGAGTGGATC CTGCAGAAAAAGACCTATGTGACCTTGGGCGTGGCTGTGGCTGGCTTCCTGCTGGGCATC CCCCTCACCAGCCAGGCAGGCATCTATTGGCTGCTGCTGATGGACAACTATGCGGCCAGC TTCTCCTTGGTGGTCATCTCCTGCATCATGTGTGTGGCCATCATGTACATCTACGGGCAC CGGAACTACTTCCAGGACATCCAGATGATGCTGGGATTCCCACCACCCCTCTTCTTTCAG ATCTGCTGGCGCTTCGTCTCTCCCGCCATCATCTTCTTTATTCTAGTTTTCACTGTGATC CAGTACCAGCCGATCACCTACAACCACTACCAGTACCCAGGCTGGGCCGTGGCCATTGGC TTCCTCATGGCTCTGTCCTCCGTCCTCTGCATCCCCCTCTACGCCATGTTCCGGCTCTGC CGCACAGACGGGGACACCCTCCTCCAGCGTTTGAAAAATGCCACAAAGCCAAGCAGAGAC TGGGGCCCTGCCCTCCTGGAGCACCGGACAGGGCGCTACGCCCCCACCATAGCCCCCTCT CCTGAGGACGGCTTCGAGGTCCAGCCACTGCACCCGGACAAGGCGCAGATCCCCATTGTG GGCAGTAATGGCTCCAGCCGCCTCCAGGACTCCCGGATATGA |
GenBank Gene ID | S70609 |
GeneCard ID | Not Available |
GenAtlas ID | SLC6A9 |
HGNC ID | HGNC:11056 |
Chromosome Location | 1 |
Locus | 1p33 |
References |
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