T3DB: P2Y purinoceptor 1

Name	P2Y purinoceptor 1
Synonyms	ATP receptor P2Y1 Purinergic receptor
Gene Name	P2RY1
Organism	Human
Amino acid sequence	>lcl\|BSEQ0013693\|P2Y purinoceptor 1 MTEVLWPAVPNGTDAAFLAGPGSSWGNSTVASTAAVSSSFKCALTKTGFQFYYLPAVYIL VFIIGFLGNSVAIWMFVFHMKPWSGISVYMFNLALADFLYVLTLPALIFYYFNKTDWIFG DAMCKLQRFIFHVNLYGSILFLTCISAHRYSGVVYPLKSLGRLKKKNAICISVLVWLIVV VAISPILFYSGTGVRKNKTITCYDTTSDEYLRSYFIYSMCTTVAMFCVPLVLILGCYGLI VRALIYKDLDNSPLRRKSIYLVIIVLTVFAVSYIPFHVMKTMNLRARLDFQTPAMCAFND RVYATYQVTRGLASLNSCVDPILYFLAGDTFRRRLSRATRKASRRSEANLQSKSEDMTLN ILPEFKQNGDTSL
Number of residues	373
Molecular Weight	42071.08
Theoretical pI	Not Available
GO Classification	Functions ADP-activated adenosine receptor activity ATP-activated adenosine receptor activity G-protein coupled purinergic nucleotide receptor activity scaffold protein binding receptor activity ADP binding ATP binding Processes response to growth factor adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway platelet activation signal transduction involved in regulation of gene expression glial cell migration negative regulation of norepinephrine secretion positive regulation of cytosolic calcium ion concentration positive regulation of protein phosphorylation negative regulation of binding positive regulation of transcription from RNA polymerase II promoter positive regulation of hormone secretion positive regulation of ERK1 and ERK2 cascade relaxation of muscle response to mechanical stimulus regulation of receptor activity G-protein coupled receptor signaling pathway aging cell surface receptor signaling pathway protein localization to plasma membrane positive regulation of inositol trisphosphate biosynthetic process phospholipase C-activating G-protein coupled receptor signaling pathway blood coagulation positive regulation of penile erection regulation of vasodilation eating behavior positive regulation of ion transport cellular response to organic cyclic compound sensory perception of pain Components cell surface apical plasma membrane cytosol cell body neuronal postsynaptic density integral component of plasma membrane basolateral plasma membrane dendrite mitochondrion postsynaptic membrane plasma membrane
General Function	Scaffold protein binding
Specific Function	Receptor for extracellular adenine nucleotides such as ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation.
Pfam Domain Function	7tm_1 (PF00001 )
Transmembrane Regions	53-74 88-109 127-147 167-188 219-238 266-285 304-328
GenBank Protein ID	Not Available
UniProtKB ID	P47900
UniProtKB Entry Name	P2RY1_HUMAN
Cellular Location	Cell membrane
Gene sequence	>lcl\|BSEQ0013694\|P2Y purinoceptor 1 (P2RY1) ATGACCGAGGTGCTGTGGCCGGCTGTCCCCAACGGGACGGACGCTGCCTTCCTGGCCGGT CCGGGTTCGTCCTGGGGGAACAGCACGGTCGCCTCCACTGCCGCCGTCTCCTCGTCGTTC AAATGCGCCTTGACCAAGACGGGCTTCCAGTTTTACTACCTGCCGGCTGTCTACATCTTG GTATTCATCATCGGCTTCCTGGGCAACAGCGTGGCCATCTGGATGTTCGTCTTCCACATG AAGCCCTGGAGCGGCATCTCCGTGTACATGTTCAATTTGGCTCTGGCCGACTTCTTGTAC GTGCTGACTCTGCCAGCCCTGATCTTCTACTACTTCAATAAAACAGACTGGATCTTCGGG GATGCCATGTGTAAACTGCAGAGGTTCATCTTTCATGTGAACCTCTATGGCAGCATCTTG TTTCTGACATGCATCAGTGCCCACCGGTACAGCGGTGTGGTGTACCCCCTCAAGTCCCTG GGCCGGCTCAAAAAGAAGAATGCGATCTGTATCAGCGTGCTGGTGTGGCTCATTGTGGTG GTGGCGATCTCCCCCATCCTCTTCTACTCAGGTACCGGGGTCCGCAAAAACAAAACCATC ACCTGTTACGACACCACCTCAGACGAGTACCTGCGAAGTTATTTCATCTACAGCATGTGC ACGACCGTGGCCATGTTCTGTGTCCCCTTGGTGCTGATTCTGGGCTGTTACGGATTAATT GTGAGAGCTTTGATTTACAAAGATCTGGACAACTCTCCTCTGAGGAGAAAATCGATTTAC CTGGTAATCATTGTACTGACTGTTTTTGCTGTGTCTTACATCCCTTTCCATGTGATGAAA ACGATGAACTTGAGGGCCCGGCTTGATTTTCAGACCCCAGCAATGTGTGCTTTCAATGAC AGGGTTTATGCCACGTATCAGGTGACAAGAGGTCTAGCAAGTCTCAACAGTTGTGTGGAC CCCATTCTCTATTTCTTGGCGGGAGATACTTTCAGAAGGAGACTCTCCCGAGCCACAAGG AAAGCTTCTAGAAGAAGTGAGGCAAATTTGCAATCCAAGAGTGAAGACATGACCCTCAAT ATTTTACCTGAGTTCAAGCAGAATGGAGATACAAGCCTGTGA
GenBank Gene ID	Not Available
GeneCard ID	Not Available
GenAtlas ID	Not Available
HGNC ID	HGNC:8539
Chromosome Location	3
Locus	Not Available
References	Leon C, Vial C, Cazenave JP, Gachet C: Cloning and sequencing of a human cDNA encoding endothelial P2Y1 purinoceptor. Gene. 1996 Jun 1;171(2):295-7. 8666290 Ayyanathan K, Webbs TE, Sandhu AK, Athwal RS, Barnard EA, Kunapuli SP: Cloning and chromosomal localization of the human P2Y1 purinoceptor. Biochem Biophys Res Commun. 1996 Jan 26;218(3):783-8. 8579591 Janssens R, Communi D, Pirotton S, Samson M, Parmentier M, Boeynaems JM: Cloning and tissue distribution of the human P2Y1 receptor. Biochem Biophys Res Commun. 1996 Apr 25;221(3):588-93. 8630005 Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. 15489334 Jin J, Daniel JL, Kunapuli SP: Molecular basis for ADP-induced platelet activation. II. The P2Y1 receptor mediates ADP-induced intracellular calcium mobilization and shape change in platelets. J Biol Chem. 1998 Jan 23;273(4):2030-4. 9442040 Zahedi RP, Lewandrowski U, Wiesner J, Wortelkamp S, Moebius J, Schutz C, Walter U, Gambaryan S, Sickmann A: Phosphoproteome of resting human platelets. J Proteome Res. 2008 Feb;7(2):526-34. Epub 2007 Dec 19. 18088087