Dual specificity mitogen-activated protein kinase kinase 3

NameDual specificity mitogen-activated protein kinase kinase 3
Synonyms
  • 2.7.12.2
  • MAP kinase kinase 3
  • MAPK/ERK kinase 3
  • MEK 3
  • MEK3
  • MKK3
  • PRKMK3
  • SAPK kinase 2
  • SAPKK-2
  • SAPKK2
  • SKK2
  • Stress-activated protein kinase kinase 2
Gene NameMAP2K3
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009088|Dual specificity mitogen-activated protein kinase kinase 3
MESPASSQPASMPQSKGKSKRKKDLRISCMSKPPAPNPTPPRNLDSRTFITIGDRNFEVE
ADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDINMRTVDC
FYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGEIAVSIVRALEHL
HSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPEL
NQKGYNVKSDVWSLGITMIEMAILRFPYESWGTPFQQLKQVVEEPSPQLPADRFSPEFVD
FTAQCLRKNPAERMSYLELMEHPFFTLHKTKKTDIAAFVKEILGEDS
Number of residues347
Molecular Weight39318.05
Theoretical pINot Available
GO Classification
Functions
  • protein tyrosine kinase activity
  • protein kinase binding
  • MAP kinase kinase activity
  • ATP binding
  • protein serine/threonine kinase activity
Processes
  • regulation of apoptotic process
  • toll-like receptor 4 signaling pathway
  • toll-like receptor 5 signaling pathway
  • toll-like receptor 9 signaling pathway
  • toll-like receptor signaling pathway
  • toll-like receptor TLR1
  • innate immune response
  • toll-like receptor TLR6
  • positive regulation of transcription, DNA-templated
  • TRIF-dependent toll-like receptor signaling pathway
  • regulation of mitotic cell cycle
  • cardiac muscle contraction
  • activation of MAPK activity
  • signal transduction by protein phosphorylation
  • positive regulation of protein kinase activity
  • stress-activated protein kinase signaling cascade
  • MyD88-dependent toll-like receptor signaling pathway
  • regulation of cytokine biosynthetic process
  • MyD88-independent toll-like receptor signaling pathway
  • signal transduction
  • stress-activated MAPK cascade
  • toll-like receptor 10 signaling pathway
  • toll-like receptor 2 signaling pathway
  • inflammatory response
  • toll-like receptor 3 signaling pathway
Components
  • cytosol
  • nucleoplasm
  • cytoplasm
  • membrane
General FunctionProtein tyrosine kinase activity
Specific FunctionDual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDP46734
UniProtKB Entry NameMP2K3_HUMAN
Cellular LocationNot Available
Gene sequence
>lcl|BSEQ0013605|Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3)
ATGTCCAAGCCACCCGCACCCAACCCCACACCCCCCCGGAACCTGGACTCCCGGACCTTC
ATCACCATTGGAGACAGAAACTTTGAGGTGGAGGCTGATGACTTGGTGACCATCTCAGAA
CTGGGCCGTGGAGCCTATGGGGTGGTAGAGAAGGTGCGGCACGCCCAGAGCGGCACCATC
ATGGCCGTGAAGCGGATCCGGGCCACCGTGAACTCACAGGAGCAGAAGCGGCTGCTCATG
GACCTGGACATCAACATGCGCACGGTCGACTGTTTCTACACTGTCACCTTCTACGGGGCA
CTATTCAGAGAGGGAGACGTGTGGATCTGCATGGAGCTCATGGACACATCCTTGGACAAG
TTCTACCGGAAGGTGCTGGATAAAAACATGACAATTCCAGAGGACATCCTTGGGGAGATT
GCTGTGTCTATCGTGCGGGCCCTGGAGCATCTGCACAGCAAGCTGTCGGTGATCCACAGA
GATGTGAAGCCCTCCAATGTCCTTATCAACAAGGAGGGCCATGTGAAGATGTGTGACTTT
GGCATCAGTGGCTACTTGGTGGACTCTGTGGCCAAGACGATGGATGCCGGCTGCAAGCCC
TACATGGCCCCTGAGAGGATCAACCCAGAGCTGAACCAGAAGGGCTACAATGTCAAGTCC
GACGTCTGGAGCCTGGGCATCACCATGATTGAGATGGCCATCCTGCGGTTCCCTTACGAG
TCCTGGGGGACCCCGTTCCAGCAGCTGAAGCAGGTGGTGGAGGAGCCGTCCCCCCAGCTC
CCAGCCGACCGTTTCTCCCCCGAGTTTGTGGACTTCACTGCTCAGTGCCTGAGGAAGAAC
CCCGCAGAGCGTATGAGCTACCTGGAGCTGATGGAGCACCCCTTCTTCACCTTGCACAAA
ACCAAGAAGACGGACATTGCTGCCTTCGTGAAGGAGATCCTGGGAGAAGACTCATAG
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:6843
Chromosome Location17
LocusNot Available
References
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