NameAcetylserotonin O-methyltransferase
Synonyms
  • 2.1.1.4
  • HIOMT
  • Hydroxyindole O-methyltransferase
Gene NameASMT
OrganismHuman
Amino acid sequence
>lcl|BSEQ0006846|Acetylserotonin O-methyltransferase
MGSSEDQAYRLLNDYANGFMVSQVLFAACELGVFDLLAEAPGPLDVAAVAAGVRASAHGT
ELLLDICVSLKLLKVETRGGKAFYRNTELSSDYLTTVSPTSQCSMLKYMGRTSYRCWGHL
ADAVREGRNQYLETFGVPAEELFTAIYRSEGERLQFMQALQEVWSVNGRSVLTAFDLSVF
PLMCDLGGGAGALAKECMSLYPGCKITVFDIPEVVWTAKQHFSFQEEEQIDFQEGDFFKD
PLPEADLYILARVLHDWADGKCSHLLERIYHTCKPGGGILVIESLLDEDRRGPLLTQLYS
LNMLVQTEGQERTPTHYHMLLSSAGFRDFQFKKTGAIYDAILARK
Number of residues345
Molecular Weight38452.51
Theoretical pI4.82
GO Classification
Functions
  • protein homodimerization activity
  • identical protein binding
  • acetylserotonin O-methyltransferase activity
  • O-methyltransferase activity
Processes
  • indolalkylamine biosynthetic process
  • methylation
  • melatonin biosynthetic process
  • translation
  • cellular nitrogen compound metabolic process
  • small molecule metabolic process
Components
  • cytosol
General FunctionProtein homodimerization activity
Specific FunctionIsoform 1 catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine). Isoform 2 and isoform 3 lack enzyme activity.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID607840
UniProtKB IDP46597
UniProtKB Entry NameASMT_HUMAN
Cellular LocationNot Available
Gene sequence
>lcl|BSEQ0019436|Acetylserotonin O-methyltransferase (ASMT)
ATGGGATCCTCAGAGGACCAGGCCTATCGCCTCCTTAATGACTACGCCAACGGCTTCATG
GTGTCCCAGGTTCTCTTCGCCGCCTGCGAGCTGGGCGTGTTTGACCTTCTCGCCGAGGCC
CCAGGGCCCCTGGACGTGGCGGCAGTGGCTGCAGGTGTGAGGGCCAGCGCCCATGGGACA
GAGCTCCTGCTGGACATCTGTGTGTCCCTGAAGCTGCTGAAAGTGGAGACGAGGGGAGGA
AAAGCTTTCTATCGAAACACAGAGCTGTCCAGCGACTACCTGACCACGGTCAGCCCGACG
TCACAATGCAGCATGCTGAAGTACATGGGCAGGACCAGCTACCGGTGCTGGGGCCACCTG
GCAGACGCCGTGAGAGAAGGAAGGAACCAGTACCTGGAGACGTTTGGCGTTCCCGCTGAA
GAGCTTTTTACGGCCATCTACAGGTCCGAGGGCGAGCGGCTACAGTTCATGCAAGCTCTG
CAGGAGGTCTGGAGCGTCAACGGGAGAAGCGTGCTGACCGCCTTTGACCTGTCAGTGTTC
CCACTTATGTGTGACCTTGGTGGGACATGGATAAAGCTGGAAACCATCATTCTCAGCAAA
CTATCGCAAGGACAGAAAACCAAACACCGCGTGTTCTCACTCATAGGTGGGGCTGGAGCT
CTGGCTAAGGAATGCATGTCTCTGTACCCTGGATGTAAGATCACCGTTTTTGACATCCCA
GAAGTGGTGTGGACGGCAAAGCAGCACTTCTCATTCCAGGAGGAAGAACAGATTGACTTC
CAGGAAGGGGATTTCTTCAAAGACCCTCTTCCGGAAGCTGATCTGTACATCCTGGCCAGG
GTCCTCCATGACTGGGCAGACGGAAAGTGCTCACACCTGCTGGAGAGGATCTACCACACT
TGCAAGCCAGGTGGTGGCATTCTGGTAATTGAAAGCCTCCTGGATGAAGACAGGCGAGGT
CCTCTGCTCACGCAGCTCTACTCTCTGAACATGCTTGTGCAGACGGAAGGGCAGGAGAGG
ACCCCCACCCACTACCACATGCTCCTCTCTTCTGCTGGCTTCAGAGACTTCCAGTTTAAG
AAAACAGGAGCCATTTATGATGCCATTTTAGCCAGGAAATAA
GenBank Gene IDU11090
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:750
Chromosome LocationX, Y
LocusNot Available
References
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