NameNeutral amino acid transporter A
Synonyms
  • Alanine/serine/cysteine/threonine transporter 1
  • ASCT-1
  • ASCT1
  • SATT
  • Solute carrier family 1 member 4
Gene NameSLC1A4
OrganismHuman
Amino acid sequence
>lcl|BSEQ0000958|Neutral amino acid transporter A
MEKSNETNGYLDSAQAGPAAGPGAPGTAAGRARRCAGFLRRQALVLLTVSGVLAGAGLGA
ALRGLSLSRTQVTYLAFPGEMLLRMLRMIILPLVVCSLVSGAASLDASCLGRLGGIAVAY
FGLTTLSASALAVALAFIIKPGSGAQTLQSSDLGLEDSGPPPVPKETVDSFLDLARNLFP
SNLVVAAFRTYATDYKVVTQNSSSGNVTHEKIPIGTEIEGMNILGLVLFALVLGVALKKL
GSEGEDLIRFFNSLNEATMVLVSWIMWYVPVGIMFLVGSKIVEMKDIIVLVTSLGKYIFA
SILGHVIHGGIVLPLIYFVFTRKNPFRFLLGLLAPFATAFATCSSSATLPSMMKCIEENN
GVDKRISRFILPIGATVNMDGAAIFQCVAAVFIAQLNNVELNAGQIFTILVTATASSVGA
AGVPAGGVLTIAIILEAIGLPTHDLPLILAVDWIVDRTTTVVNVEGDALGAGILHHLNQK
ATKKGEQELAEVKVEAIPNCKSEEETSPLVTHQNPAGPVASAPELESKESVL
Number of residues532
Molecular Weight55722.455
Theoretical pI6.18
GO Classification
Functions
  • L-hydroxyproline transmembrane transporter activity
  • L-serine transmembrane transporter activity
  • L-threonine transmembrane transporter activity
  • L-glutamine transmembrane transporter activity
  • L-cystine transmembrane transporter activity
  • chloride channel activity
  • L-alanine transmembrane transporter activity
  • sodium
  • L-proline transmembrane transporter activity
Processes
  • proline transport
  • cognition
  • chloride transmembrane transport
  • ion transport
  • amino acid transport
  • L-serine transport
  • glutamine transport
  • chloride transport
  • hydroxyproline transport
  • threonine transport
  • L-cystine transport
  • mitophagy in response to mitochondrial depolarization
  • L-alanine transport
  • synaptic transmission, glutamatergic
  • transmembrane transport
  • proline transmembrane transport
Components
  • intermediate filament
  • neuronal cell body
  • melanosome
  • membrane
  • plasma membrane
  • cell surface
  • integral component of membrane
  • extracellular exosome
  • microtubule organizing center
  • integral component of plasma membrane
  • centrosome
  • dendrite
General FunctionSodium:dicarboxylate symporter activity
Specific FunctionTransporter for alanine, serine, cysteine, and threonine. Exhibits sodium dependence.
Pfam Domain Function
Transmembrane Regions42-62 88-108 119-139 217-237 257-277 298-318 328-348 373-393 418-438
GenBank Protein ID348012
UniProtKB IDP43007
UniProtKB Entry NameSATT_HUMAN
Cellular LocationMembrane
Gene sequence
>lcl|BSEQ0020463|Neutral amino acid transporter A (SLC1A4)
ATGAACATTTTAGGATTGGTCCTGTTTGCTCTGGTGTTAGGAGTGGCCTTAAAGAAACTA
GGCTCCGAAGGAGAAGACCTCATCCGTTTCTTCAATTCCCTCAACGAGGCGACGATGGTG
CTGGTGTCCTGGATTATGTGCTCAGCGACCCTTCCCTCTATGATGAAGTGCATTGAAGAG
AACAATGGTGTGGACAAGAGGATCAGCAGGTTTATTCTCCCCATCGGGGCCACCGTGAAC
ATGGACGGAGCAGCCATCTTCCAGTGTGTGGCCGCGGTGTTCATTGCGCAACTCAACAAC
GTAGAGCTCAACGCAGGACAGATTTTCACCATTCTAGTGACTGCCACAGCGTCCAGTGTT
GGAGCAGCAGGCGTGCCAGCTGGAGGGGTCCTCACCATTGCCATTATCCTGGAGGCCATT
GGGCTGCCTACTCATGACCTGCCTCTGATCCTGGCTGTGGACTGGATTGTGGACCGGACC
ACCACGGTGGTGAATGTGGAAGGGGATGCCCTGGGTGCAGGCATTCTCCACCACCTGAAT
CAGAAGGCAACAAAGAAAGGCGAGCAGGAACTTGCTGAGGTGAAAGTGGAAGCCATCCCC
AACTGCAAGTCTGAGGAGGAGACATCGCCCCTGGTGACACACCAGAACCCCGCTGGCCCC
GTGGCCAGTGCCCCAGAACTGGAATCCAAGGAGTCGGTTCTGTGA
GenBank Gene IDL14595
GeneCard IDNot Available
GenAtlas IDSLC1A4
HGNC IDHGNC:10942
Chromosome Location2
Locus2p15-p13
References
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